Effect of Surfactants and Cosurfactants on the Characteristics of Mangosteen Rind Extract Hand Body Lotion
Abstract
The surfactants and co-surfactants combination in nanoemulsion formulations is important to obtain optimal formulations. Mangosteen rind extract has various benefits. Objective: determine the effect of a combination of surfactant (Tween 80) and Co surfactant (PEG 400) on the physical characteristics of mangosteen rind extract nanoemulsion. The research method was carried out by comparing the physical characteristics of the nanoemulsion formula of mangosteen rind extract by testing pH, viscosity and particle diameter. Three formulas were made (F1, F2 and F3) and one formula without co-surfactant as a negative control (KN). The combination of surfactant and cosurfactant provided pH, viscosity and particle diameter characteristics that were significantly different between formulas and with the negative control. The combination of surfactants and co-surfactants influences the properties of Mangosteen Rind Extract (Garcinia mangostana L) Hand and Body Lotion.
References
Ariyanti, A., Masruriati, E., Setyowati, D., & Nurulita, F. (2023). Analysis of Moringa Leaf Nanoemulgel (Moringa Oleifera L.) and Aloe Vera as A Moisturizer for Male Rabbits in New Zealand. Indonesian Journal of Global Health Research, 5(3), 433-440. https://doi.org/10.37287/ijghr.v5i3.2057
Bakri, D., Muhtadi, M., & Wikantyasning, E. (2023). Formulation and Characterization of Nanoemulsion from Traditional Extracts for Antidiabetic. Indonesian Journal of Global Health Research, 5(3), 441-448. https://doi.org/10.37287/ijghr.v5i3.2035
Choudhury, H., Gorain, B., Pandey, M., Chatterjee, L. A., Sengupta, P., Das, A., Molugulu, N., & Kesharwani, P. (2017). Recent Update on Nanoemulgel as Topical Drug Delivery System. Journal of Pharmaceutical Sciences, 106(7), 1736–1751. https://doi.org/10.1016/j.xphs.2017.03.042
Ghosh, S., Ray, A., & Pramanik, N. (2020). Self-assembly of surfactants: An overview on general aspects of amphiphiles. Biophysical Chemistry, 265(July), 106429. https://doi.org/10.1016/j.bpc.2020.106429
Kumar, S., Wadhwa, K., Pahwa, R., Ali, J., & Baboota, S. (2024). Screening of surfactant mixture ratio for preparation of oil-in-water nanoemulsion: A technical note. Journal of Applied Pharmaceutical Science, 14(10), 121–127. https://doi.org/10.7324/japs.2024.180648
Lestari, S. R., Gofur, A., Fajaroh, F., Maslikah, S. L., Annisa, Y., & Malek, N. A. N. N. (2021). Self-nanoemulsifying drug delivery system (SNEEDS) for improved bioavailability of active compound on single clove garlic: Optimization of PEG 400 and glycerol as co-surfactant. AIP Conference Proceedings, 2353(May 2023). https://doi.org/10.1063/5.0052638
Li, G. Z., & Friberg, S. E. (1982). Surfactant/cosurfactant association and emulsion stability. Journal of the American Oil Chemists Society, 59(12), 569–572. https://doi.org/10.1007/BF02636326
Mahendra, J., Sharma, V., Mahendra, L., Janani, M., Hussain, S. T., Janarthan, S., & Dave, P. H. (2021). Mangosteen (Garcinia mangostana): Compositional profile and usage in cancer molecular docking studies. Onkologia i Radioterapia, 15(12), 42–47.
Mardiyanto, Mohadi, R., Fithri, N. A., & Kurniawan, G. (2024). Optimization of Nanoemulsion Formula Containing Erythromycin with VCO and Varying Concentrations of Tween-80 and PEG-400. Science and Technology Indonesia, 9(3), 697–709. https://doi.org/10.26554/sti.2024.9.3.697-709
Matan, N., Kongchoosi, N., Sinthupachee, A., & Chaidech, P. (2024). Nutritional and bioactive compound analysis of mangosteen fruit in hill and flat land plantations, during both the season and off-season, in provinces along the Gulf of Thailand and the Andaman Sea. NFS Journal, 36(June), 100182. https://doi.org/10.1016/j.nfs.2024.100182
Mawazi, S. M., Ann, J., Othman, N., Khan, J., Alolayan, S. O., Al Thagfan, S. S., & Kaleemullah, M. (2022). A Review of Moisturizers; History, Preparation, Characterization and Applications. Cosmetics, 9(3), 1–19. https://doi.org/10.3390/cosmetics9030061
Miksusanti, Apriani, E. F., & Bihurinin, A. H. B. (2023). Optimization of Tween 80 and PEG-400 Concentration in Indonesian Virgin Coconut Oil Nanoemulsion as Antibacterial against Staphylococcus aureus. Sains Malaysiana, 52(4), 1259–1272. https://doi.org/10.17576/JSM-2023-5204-17
Mishra, M., Muthuprasanna, P., Prabha, K. S., Rani, P. S., Babu, I. A. S., Chandiran, I. S., Arunachalam, G., & Shalini, S. (2009). Basics and potential applications of surfactants - A review. International Journal of PharmTech Research, 1(4), 1354–1365.
N., S., CHANDRAKALA, V., & SRINIVASAN, S. (2022). Review on: Effect of Oil, Surfactant and Cosurfactant on Microemulsion. International Journal of Current Pharmaceutical Research, 14(4), 23–27. https://doi.org/10.22159/ijcpr.2022v14i4.2011
Nikam, T. H., Patil, M. P., Patil, S. S., Vadnere, G. P., & Lodhi, S. (2018). Nanoemulsion: A brief review on development and application in Parenteral Drug Delivery. Advance Pharmaceutical Journal, 3(2), 43–54. https://doi.org/10.31024/apj.2018.3.2.2
Pavoni, L., Perinelli, D. R., Bonacucina, G., Cespi, M., & Palmieri, G. F. (2020). An overview of micro-and nanoemulsions as vehicles for essential oils: Formulation, preparation and stability. Nanomaterials, 10(1). https://doi.org/10.3390/nano10010135
Pohan, J., & Rahmawati, F. (2022). The effect of mangosteen pericarp (Garcinia mangostana Linn) extract on inhibits the growth of bacteria Escherichia Coli ATCC 25922 and bacteria Staphylococcus Aureus ATCC 25923. International Journal of Research in Pharmacy and Pharmaceutical Sciences, 7(2), 29–38. www.pharmacyjournal.in
Riezqa Nur Attazqiah, & Ambarwati, N. S. S. (2021). Studi Literatur: Pemanfaatan Ekstrak Kulit Buah Manggis (Garcinia mangostana L.) Untuk Perawatan Kulit Wajah. Jurnal Tata Rias, 11(1), 101–110. https://doi.org/10.21009/11.1.12.2009
Rohman, A., Arifah, F. H., Irnawati, Alam, G., Muchtaridi, & Rafi, M. (2020). A review on phytochemical constituents, role on metabolic diseases, and toxicological assessments of underutilized part of Garcinia mangostana L. fruit. Journal of Applied Pharmaceutical Science, 10(7), 127–146. https://doi.org/10.7324/JAPS.2020.10716
Sari, A. I., Herdiana, Y., Raya, J., & Sumedang Km 21 Jatinangor, B. (2021). Review: Formulasi Nanoemulsi Terhadap Peningkatan Kualitas Obat. Farmaka, 16(1), 247–254.
Shahaban, S. O. (2023). A review: Mangosteen an untapped source of bioactive. ~ 1619 ~ The Pharma Innovation Journal, 12(7), 1619–1628. www.thepharmajournal.com
S. M., W., Leliqia, N., & C.I.S, A. (2013). Optimasi Komposisi Span® 60 Dan Tween® 80 Sebagai Emulgator Terhadap Stabilitas Fisik Dalam Formulasi Cold Cream Ekstrak Kulit Buah Manggis (Garcinia mangostana L.). Jurnal Farmasi Udayana, . Retrieved from https://ojs.unud.ac.id/index.php/jfu/article/view/5760
Taher, S. S., Al-Kinani, K. K., Hammoudi, Z. M., & Ghareeb, M. mohammed. (2022). Co-surfactant effect of polyethylene glycol 400 on microemulsion using BCS class II model drug. Journal of Advanced Pharmacy Education and Research, 12(1), 63–69. https://doi.org/10.51847/1H17TZQGYI
Yati, K., Amalia, A., & Puspasari, D. (2018). Effect of Increasing Concentrations of Tween 80 and Sorbitol as Surfactants and Cosurfactans Against the Physical Stability Properties of Palm Oil Microemulsion. Advanced Science Letters, 23(12), 12506–12509. https://doi.org/10.1166/asl.2017.10803
Yuan, C. L., Xu, Z. Z., Fan, M. X., Liu, H. Y., Xie, Y. H., & Zhu, T. (2014). Estudio sobre las caracteristicas y el daño de los tensioactivos. Journal of Chemical and Pharmaceutical Research, 6(7), 2233–2237.
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