Physical Exercise to Improve Immunity During the Pandemic Covid-19

  • Yolinda Suciliyana Universitas Indonesia
  • Widyatuti Widyatuti Universitas Indonesia
Keywords: covid-19, immunity, physical exercise


Maintaining body immunity throughout the COVID-19 pandemic is one of the efforts to protect the body in opposition to disease. Adequate physical exercise is very necessary to prevent the body from attacking disease. This literature review objectives to determine the advantages of physical exercise to expand body immunity for the duration of the COVID-19 pandemic. This study uses a literature review. Literature searches were collected using online database such as Science Direct, Springer Link, Wiley online Library, SAGE publication, NCBI and Google Scholar so that 12 articles were used in this literature review that published from 2019-2021. These articles are then analyzed by narrative literature review. Studies exhibit that moderate physical exercise can enhance body immunity and respiratory function. Moderate types of physical exercise such as aerobics can increasing the immunity by using the increasing the degree and function of T-lymphocytes, immunoglobulins, mainly Ig A and Ig G, regulating C-reactive protein levels to prevent limit lung feature and extend the vital capacity of the lungs. Regular physical workout of moderate intensity has been proven to extensively affect the immune system and reduce the threat of infection disease.


Aktug, Z. B., & Demir, N. A. (2020). An exercise prescription for covid-19 pandemic. Pakistan Journal of Medical Sciences, 36(7), 1732–1736.

Amatriain-Fernández, S., Murillo-Rodríguez, E. S., Gronwald, T., Machado, S., & Budde, H. (2020). Benefits of Physical Activity and Physical Exercise in the Time of Pandemic. Psychological Trauma: Theory, Research, Practice, and Policy, 12(S1), 264–266.

Buzzi, C., Tucci, M., Ciprandi, R., Brambilla, I., Caimmi, S., Ciprandi, G., & Marseglia, G. L. (2020). The psycho-social effects of COVID-19 on Italian adolescents attitudes and behaviors. Italian Journal of Pediatrics, 46(1), 4–10.

Campbell, J. P., & Turner, J. E. (2018). Debunking the myth of exercise-induced immune suppression: Redefining the impact of exercise on immunological health across the lifespan. Frontiers in Immunology, 9(APR), 1–21.

Cascella, M., Rajnik, M., Cuomo, A., Dulebohn, S. C., & Di Napoli, R. (2020). Features, evaluation, and treatment of coronavirus. In NCBI Bookshelf (pp. 1–24). StatPearls Publishing.

Chieffi, S., Messina, G., Villano, I., Messina, A., Valenzano, A., Moscatelli, F., Salerno, M., Sullo, A., Avola, R., Monda, V., Cibelli, G., & Monda, M. (2017). Neuroprotective effects of physical activity: Evidence from human and animal studies. Frontiers in Neurology, 8(May), 1–7.

Corbett, G. A., Milne, S. J., Hehir, M. P., Lindow, S. W., & O’connell, M. P. (2020). Health anxiety and behavioural changes of pregnant women during the COVID-19 pandemic. European Journal of Obstetrics and Gynecology and Reproductive Biology, 2019, 2019–2020.

da Silveira, M. P., da Silva Fagundes, K. K., Bizuti, M. R., Starck, É., Rossi, R. C., & de Resende e Silva, D. T. (2021). Physical exercise as a tool to help the immune system against COVID-19: an integrative review of the current literature. Clinical and Experimental Medicine, 21(1), 15–28.

Fernandes, J., Arida, R. M., & Gomez-Pinilla, F. (2017). Physical exercise as an epigenetic modulator of brain plasticity and cognition. Neuroscience and Biobehavioral Reviews, 80(February), 443–456.

Furtado, G. E., Letieri, R. V., Caldo-Silva, A., Sardão, V. A., Teixeira, A. M., Barros, M. P. de, Vieira, R. P., & Bachi, A. L. L. (2021). Sustaining efficient immune functions with regular physical exercise in the COVID‐19 era and beyond. In Eur J Clin Invest (pp. 1–10).

Hoseini, R. (2020). How to Exercise During Coronavirus Quarantine? Caspian Journal of Internal Medicine, 11(Suppl 1), 479–483.

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet, 395(10223), 497–506.

Jee, Y. S. (2020). Physical exercise for strengthening innate immunity during COVID-19 pandemic: 4th series of scientific evidence. Journal of Exercise Rehabilitation, 16(5), 383–384.

Jesus, I., Vanhee, V., Deramaudt, T. B., & Bonay, M. (2021). Promising effects of exercise on the cardiovascular, metabolic and immune system during COVID-19 period. Journal of Human Hypertension, 35(1), 1–3.

Kahl, H. W., & D.Cook, H. (2013). Educating the student body: Taking physical activity and physical education to school.

Kostrzewa-Nowak, D., Kubaszewska, J., Nowakowska, A., & Nowak, R. (2020). Effect of Aerobic and Anaerobic Exercise on the Complement System of Proteins in Healthy Young Males. Journal of Clinical Medicine, 9(8), 2357.

Laddu, D. R., Lavie, C. J., Phillips, S. A., & Arena, R. (2021). Physical activity for immunity protection: Inoculating populations with healthy living medicine in preparation for the next pandemic. Progress in Cardiovascular Diseases, 64, 102–104.

Mandolesi, L., Gelfo, F., Serra, L., Montuori, S., Polverino, A., Curcio, G., & Sorrentino, G. (2017). Environmental factors promoting neural plasticity: Insights from animal and human studies. Neural Plasticity, 2017.

Mohamed, A. A., & Alawna, M. (2020). Role of increasing the aerobic capacity on improving the function of immune and respiratory systems in patients with coronavirus (COVID-19): A review. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14(4), 489–496.

Mousavizadeh, L., & Ghasemi, S. (2020). Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection, 1–5.

Nieman, D. C. (2020). Coronavirus disease-2019: A tocsin to our aging, unfit, corpulent, and immunodeficient society. Journal of Sport and Health Science, 9(4), 293–301.

Nies, M. A., & McEwen, M. (2019). Keperawatan Kesehatan Komunitas dan Keluarga (J. Sahar, A. Setiawan, & M. Riasmini, N (eds.); Edisi Indo). Elsevier Ltd.

Pal, G. K. (2020). Yoga to combat and prevent COVID-19. International Journal of Clinical and Experimental Physiology, 7(2), 46–47.

Pande, P., Tendolkar, V., Suraj, S., & Anjankar, A. (2020). Yoga helps to improve immunity & fight against infection during covid19. Indian Journal of Forensic Medicine and Toxicology, 14(4), 7011–7014.

Ranasinghe, C., Ozemek, C., & Arena, R. (2020). Exercise and well-being during COVID 19: Time to boost your immunity. Expert Review of Anti-Infective Therapy, 18(12), 1195–1200.

Report, M. W. (2012). CDC ’ s Vision for Public Health Surveillance in the 21 st Century. 61(July 2012).

Roy, R., & Mukhopadhyay, M. K. (2020). Yoga for combat with COVID-19 epidemic. International Journal of Yogic, Human Movement and Sports Sciences, 5(1), 97–99.

Scheffer, D. da L., & Latini, A. (2020). Exercise-induced immune system response: Anti-inflammatory status on peripheral and central organs. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1866(10), 1–15.

Simpson, R. J., Campbell, J. P., Gleeson, M., Krüger, K., Nieman, D. C., Pyne, D. B., Turner, J. E., & Walsh, N. P. (2020). Can exercise affect immune function to increase susceptibility to infection? Exercise and Susceptibility to Infection, 26, 8–22.

Tanwar, A. K., & Rajan, S. (2020). Yoga: A nonpharmacological approach against current pandemic of Coronavirus Disease ‑19. Journal of Ayurveda, 143–146.

Xiang, M., & Zhang, Z. (2020). Impact of COVID-19 Pandemic on Children and Adolescents Lifestyle Behavior Larger Than Expected. Progress in Cardiovascular Diseases, January, 1–2.

Yuksel, B., & Ozgor, F. (2020). Effect of the COVID-19 pandemic on female sexual behavior. International Journal of Gynaecology and Obstetrics: The Official Organ of the International Federation of Gynaecology and Obstetrics, May, 1–5.

How to Cite
Suciliyana, Y., & Widyatuti, W. (2021). Physical Exercise to Improve Immunity During the Pandemic Covid-19. Proceedings of the International Conference on Nursing and Health Sciences, 2(1), 19-26. Retrieved from