Cutaneous Polyarteritis Nodosa: A Case Report
Abstract
Cutaneous polyarteritis nodosa is a rare type of vasculitis that involves inflammation in small to medium-sized blood vessels, mainly targeting the skin. It affects people of all ages and significantly impacts both the skin and other organ systems. This case report aims to describe the clinical presentation, diagnostic approach, and therapeutic response. A 38-year-old man came with a two-week history of a red, non-itchy rash on both legs. A week before the rash appeared, patient experienced fever, sore throat, and stomach pain. His general condition was stable. Dermatological examination showed multiple palpable purpura on both legs, ranging from miliary to lenticular in size. Diascopy revealed non-blanching purpura, and dermoscopy showed a homogeneous pattern of multiple erythematous spots. Histopathology indicated a proliferation of blood vessels with enlarged endothelial cells, concluding with a diagnosis of polyarteritis nodosa. Patient was diagnosed with cutaneous polyarteritis nodosa and treated with methylprednisolone at 1 mg/kg/day, divided into three doses of 32 mg each, with tapering off every week. Clinical improvement was observed, and the skin lesions progressively resolved. This case highlights the importance of early recognition and corticosteroid therapy in the successful management of mild cutaneous polyarteritis nodosa.
Keywords: corticosteroid, cutaneous polyarteritis nodosa, vasculitis
References
Chung, S. A., Gorelik, M., Langford, C. A., Maz, M., Abril, A., Guyatt, G., Archer, A. M., Conn, D. L., Full, K. A., Grayson, P. C., Ibarra, M. F., Imundo, L. F., Kim, S., Merkel, P. A., Rhee, R. L., Seo, P., Stone, J. H., Sule, S., Sundel, R. P., … Mustafa, R. A. (2021). 2021 American College of Rheumatology/Vasculitis Foundation guideline for the management of polyarteritis nodosa. Arthritis Care & Research, 73(8), 1061–1070. https://doi.org/10.1002/acr.24633
Furukawa, F. (2012). Cutaneous polyarteritis nodosa: An update. Annals of Vascular Diseases, 5(3), 282–288. https://doi.org/10.3400/avd.ra.12.00043
Okazaki, T., Shinagawa, S., & Mikage, H. (2017). Vasculitis syndrome—Diagnosis and therapy. Journal of General and Family Medicine, 18(2), 72–78. https://doi.org/10.1002/jgf2.16
Ordoñez-Parra, J., Castellanos-Angarita, A., Casas-Barrera, M. A., Rondón-Carvajal, J., & Cuéllar Ríos, I. C. (2021). Cutaneous polyarteritis nodosa: An atypical simulator. Report of 3 cases and a narrative review of the literature. Revista Colombiana de Reumatología, 28(3), 248–256. https://doi.org/10.1016/j.rcreu.2020.12.004
Hiraiwa, T., Chen, K.-R., & Yamamoto, T. (2023). Cutaneous arteritis: Clinicopathological study of 21 cases. Journal of Cutaneous Immunology and Allergy, 6(3), 146–151. https://doi.org/10.1002/cia2.12305
Mattaeoda, M. A., Bocian, M., Sala, J., Stefano, P. C., Kstsicas, M. M., & Cervini, A. B. (2015). Cutaneous polyarteritis nodosa. Anais Brasileiros de Dermatologia, 90(3 Suppl 1), S80–S83. https://doi.org/10.1590/abd1806-4841.20153395
Micheletti, R. G. (2022). Treatment of cutaneous vasculitis. Frontiers in Medicine, 9, 1059612. https://doi.org/10.3389/fmed.2022.1059612
Munera Campos, M., Bielsa, I., Martínez Morillo, M., Aparicio, G., Olivé, A., & Ferrándiz, C. (2020). Manifestations, clinical course and prognostic markers in cutaneous polyarteritis nodosa. Journal der Deutschen Dermatologischen Gesellschaft, 18(11), 1250–1259. https://doi.org/10.1111/ddg.14271
Pineider, J., Weon, J., West, L., Nanes, B., Vandergriff, T., & Mauskar, M. M. (2020). Cutaneous polyarteritis nodosa with clinical features of pyoderma gangrenosum. JAAD Case Reports, 6(12), 1291–1293. https://doi.org/10.1016/j.jdcr.2020.09.001
Reamy, B. V., Servey, J. T., & Williams, P. M. (2020). Henoch Schönlein purpura (IgA vasculitis): Rapid evidence review. American Family Physician, 102(4), 229–233.
Stanton, M., & Tiwari, V. (2023). Polyarteritis nodosa. In StatPearls. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK538313/
Thakur, Y., Meshram, R. J., & Taksande, A. (2024). Diagnosis and management of immune thrombocytopenia in paediatrics: A comprehensive review. Cureus, 16(9), e69635. https://doi.org/10.7759/cureus.69635
Wang, C. R., & Tsai, H. W. (2021). Human hepatitis viruses associated cutaneous and systemic vasculitis. World Journal of Gastroenterology, 27(1), 19–36. https://doi.org/10.3748/wjg.v27.i1.19
Wolff, L., Horisberger, A., Moi, L., Karampetsou, M. P., & Comte, D. (2023). Polyarteritis nodosa: Old disease, new etiologies. International Journal of Molecular Sciences, 24(23), 16668. https://doi.org/10.3390/ijms242316668.
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