The Effectiveness of Massage Therapy in Reducing Fatigue among Cancer Patients Undergoing Chemotherapy: Systematic Review

Keywords: cancer, chemotherapy, fatigue, massage therapy, systematic review

Abstract

Fatigue is one of the most common side effects experienced by cancer patients undergoing chemotherapy and has a serious impact on quality of life. Massage therapy has emerged as a potential non-pharmacological intervention to alleviate this symptom. Objective: To systematically review the effectiveness of massage therapy in reducing fatigue among cancer patients undergoing chemotherapy. Methods: This study employed a systematic review design based on the PRISMA guidelines. Literature was searched through PubMed, ScienceDirect, ProQuest, and Google Scholar databases. Articles published in English or Indonesian in the last 10 years (2014–2024). Included articles were randomized controlled trials (RCTs), quasi-experimental studies, or clinical trials evaluating the effects of massage therapy on fatigue in cancer patients. 139 Articles were founds and 10 article were selected. Study quality was assessed using the CASP tool, and data were analyzed descriptively. Results: A total of 10 studies met the inclusion criteria. Findings showed that massage therapy—including slow-stroke back massage, Swedish massage, hand and foot massage, and combinations with aromatherapy—was effective in reducing fatigue. The effectiveness was influenced by the type of massage, duration, and frequency of the intervention. Conclusion: Massage therapy is an effective intervention that can be integrated into clinical care to reduce fatigue in chemotherapy patients. Further research is needed to strengthen the existing evidence.

References

Alhamdoun, A., Alomari, K., & Al Qadire, M. (2020). The Effects of Massage Therapy on Symptom Management among Patients withCancer: A Systematic Review. International Research Journal of Oncology, 3(2), 38–45.

Alizadeh, J., Yeganeh, M. R., Pouralizadeh, M., Roushan, Z. A., Gharib, C., & Khoshamouz, S. (2021). The effect of massage therapy on fatigue after chemotherapy in gastrointestinal cancer patients. Supportive Care in Cancer, 29(12), 7307–7314. https://doi.org/10.1007/s00520-021-06304-8

Bahceli, P. Z., Arslan, S., & Ilik, Y. (2022). The effect of slow-stroke back massage on chemotherapy-related fatigue in women with breast cancer: An assessor blinded, parallel group, randomized control trial: Effect of Slow Stroke Back Massage on CRF. Complementary Therapies in Clinical Practice, 46(September 2021), 101518. https://doi.org/10.1016/j.ctcp.2021.101518

de Vries-ten Have, J., Winkels, R. M., Kampman, E., & Winkens, L. H. H. (2023). Behaviour change techniques used in lifestyle interventions that aim to reduce cancer-related fatigue in cancer survivors: a systematic review. International Journal of Behavioral Nutrition and Physical Activity, 20(1), 1–16. https://doi.org/10.1186/s12966-023-01524-z

Efe Arslan, D., Kılıç Akça, N., & Aslan, D. (2025). The effect of hand massage on fatigue in women with cancer receiving brachytherapy: randomized clinical trial. Supportive Care in Cancer, 33(1), 1–8. https://doi.org/10.1007/s00520-024-09059-0

Fabi, A., Bhargava, R., Fatigoni, S., Guglielmo, M., Horneber, M., Roila, F., Weis, J., Jordan, K., & Ripamonti, C. I. (2020). Cancer-related fatigue: ESMO Clinical Practice Guidelines for diagnosis and treatment. Annals of Oncology, 31(6), 713–723. https://doi.org/10.1016/j.annonc.2020.02.016

Fazeli, M., Asadizaker, M., Jahani, S., Maraghi, E., & Vosoughi, T. (2021). The Effect of the Combined Intervention of Low-Intensity Exercise and Slow Stroke Back Massage (SSBM) on Physical Activity and Severity of Fatigue in the Patients Undergoing Chemotherapy. Jundishapur Journal of Chronic Disease Care, 10(2). https://doi.org/10.5812/jjcdc.100304

Ferlay, J., Colombet, M., Soerjomataram, I., Parkin, D. M., Piñeros, M., Znaor, A., & Bray, F. (2021). Cancer statistics for the year 2020: An overview. International Journal of Cancer, 149(4), 778–789. https://doi.org/10.1002/ijc.33588

Hegazy, S., Mounier, E., Awad, I., & Abd Elhameed, S. (2023). Effect of Massage Therapy on Sleep Quality Among Elderly Women with Breast Cancer. Mansoura Nursing Journal, 10(1), 495–508. https://doi.org/10.21608/mnj.2023.322079

Indraswati, I., Septiyan, R. B., Matchaya, P., & Finch, R. (2024). Effectiveness Of Massage Therapy On Fatigue In Cancer Patients Undergoing Chemotherapy: Scoping Review. Jurnal Berita Ilmu Keperawatan, 17(1), 82–91. https://doi.org/10.23917/bik.v17i1.3817

Long, Y., Zhou, Z., Zhou, S., & Zhang, G. (2024). The effectiveness of different non-pharmacological therapies on cancer-related fatigue in cancer patients:A network meta-analysis. International Journal of Nursing Studies, 160(July), 104904. https://doi.org/10.1016/j.ijnurstu.2024.104904

Mardaneh, N., Jenabian, A., & Moghaddam, L. (2021). The Effects of Thai Massage on Comfort and Symptoms among Female Cancer Patients Receiving Chemotherapy. Nursing and Midwifery Studies, 10(1), 20–26. https://doi.org/10.4103/nms.nms_110_19

Miladinia, M., Jahangiri, M., Kennedy, A. B., Fagerström, C., Tuvesson, H., Safavi, S. S., Maniati, M., Javaherforooshzadeh, F., & Karimpourian, H. (2023). Determining massage dose-response to improve cancer-related symptom cluster of pain, fatigue, and sleep disturbance: A 7-arm randomized trial in palliative cancer care. Palliative Medicine, 37(1), 108–119. https://doi.org/10.1177/02692163221129158

Miladinia, M., Voss, J. G., Molavynejad, S., Malehi, A. S., Zarea, K., Nouri, E. M., & Ahmadzadeh, A. (2021). Slow-Stroke Back Massage Compared With Music Therapy for Leukemia-Related Pain and Fatigue: A Randomized Controlled Trial. JCO Oncology Practice, 17(11), e1614–e1621. https://doi.org/10.1200/OP.21.00156

Moradi, M., Khachian, A., Behbahani, F. A., Saatchi, K., & Haghani, H. (2020). The Effect of Aromatherapy by Inhalation and Massage on Radiotherapy-induced Fatigue in Patients With Cancer. Journal of Client-Centered Nursing Care, 6(2), 79–86. https://doi.org/10.32598/JCCNC.6.2.304.1

Mostafa, H. A. A., Ismail, L. M. N., Amien, N. M., & ... (2023). Effect of Swedish Massage Therapy on Cancer-Related Fatigue in Chemotherapy Patients. Xianshiyoudaxuexuebao.Com, 01, 333–350. https://doi.org/10.17605/OSF.IO/HRZE6

Nurpadila, N., Mulhaeriah, M., & Sangkala, M. S. (2021). Effects of massage therapy on cancer related fatigue: A systematic review. Enfermería Clínica, 31, S692–S696. https://doi.org/https://doi.org/10.1016/j.enfcli.2021.07.018

Purnamayanti, N. K. D., & Putra, M. G. A. (2021). Complementary and Alternative Therapy To Reduce Fatigue Among Oncology Patient Under Chemotherapy: a Nursing Perspective. Indonesian Contemporary Nursing Journal, 6(1), 38–46.

Ruiz-Casado, A., Álvarez-Bustos, A., de Pedro, C. G., Méndez-Otero, M., & Romero-Elías, M. (2021). Cancer-related Fatigue in Breast Cancer Survivors: A Review. Clinical Breast Cancer, 21(1), 10–25. https://doi.org/https://doi.org/10.1016/j.clbc.2020.07.011

Shu, J., Ren, W., Chen, S., Li, L., Zhu, H., & Jin, A. (2022). Effect of Somatosensory Interaction Transcutaneous Electrical Acupoint Stimulation on Cancer-related Fatigue and Immunity: A Randomized Controlled Trial. American Journal of Clinical Oncology: Cancer Clinical Trials, 45(7), 316–324. https://doi.org/10.1097/COC.0000000000000922

Thong, M. S. Y., van Noorden, C. J. F., Steindorf, K., & Arndt, V. (2020). Cancer-Related Fatigue: Causes and Current Treatment Options. Current Treatment Options in Oncology, 21(2). https://doi.org/10.1007/s11864-020-0707-5

Wang, T., Zhai, J., Liu, X. L., Yao, L. Q., & Tan, J. Y. (2021). Massage Therapy for Fatigue Management in Breast Cancer Survivors: A Systematic Review and Descriptive Analysis of Randomized Controlled Trials. Evidence-Based Complementary and Alternative Medicine, 2021. https://doi.org/10.1155/2021/9967574

Published
2025-08-01
How to Cite
Rahman, A. F., Gayatri, D., & Hargiana, G. (2025). The Effectiveness of Massage Therapy in Reducing Fatigue among Cancer Patients Undergoing Chemotherapy: Systematic Review. Indonesian Journal of Global Health Research, 7(4), 847-858. https://doi.org/10.37287/ijghr.v7i4.6500