Formulation of Palmarosa (Cymbopogon Martinii) Essential Oil Emulgel Using Sodium Carboxymethyl Cellulose (Na-CMC) as A Gelling Agent
Abstract
Palmarosa essential oil (Cymbopogon martinii) is known for its potential as a natural therapeutic agent. It contains geraniol compounds with demonstrated antimicrobial and anti-inflammatory activity. However, direct application of palmarosa essential oil to the skin is less effective and may cause irritation. Objective: This study aimed to develop a topical formulation in the form of an emulgel containing palmarosa essential oil, using sodium carboxymethyl cellulose (Na-CMC) as the gelling agent. Method: The emulgel was prepared in three different formulations containing 2%, 4%, and 6% concentrations of palmarosa essential oil. The resulting preparations were evaluated for quality through organoleptic properties, homogeneity, pH, spreadability, adhesion, and emulsion type. Data were statistically analyzed using one-way ANOVA. Results: The emulsion type test indicated that all formulations were oil-in-water (o/w) emulsions. Differences in palmarosa essential oil concentration influenced the physical properties of the emulgel, but all three formulations met the standard requirements for good physical quality of emulgel preparations.Conclusions: the three emulgel formulations containing palmarosa essential oil fulfilled the standards for acceptable physical properties.
References
Amalia, F., Maulidiyah, M., & Pratiwi, L. (2021). Study on Composition and Antioxidant Activity of Cymbopogon martinii Essential Oil. Jurnal Kimia Riset, 6(2), 89–96.
Andriani, D., & Amin, M. S. (2023). Formulasi Nanoemulgel Minyak Atsiri Palmarosa (Cymbopogon martinii) Dan Aktivitas Antiinflamasinya. Cendekia Journal of Pharmacy, 7(2), 150–158. https://doi.org/10.31596/cjp.v7i2.236
Bakkali, F., Averbeck, S., Averbeck, D., & Idaomar, M. (2008). Biological effects of essential oils – A review. Food and Chemical Toxicology, 46(2), 446–475. https://doi.org/10.1016/j.fct.2007.09.106
Baskara, I. B. B., Suhendra, L., & Wrasiati, L. P. (2020). Pengaruh Suhu Pencampuran dan Lama Pengadukan terhadap Karakteristik Sediaan Krim. Jurnal Rekayasa Dan Manajemen Agroindustri, 8(2), 200. https://doi.org/10.24843/JRMA.2020.v08.i02.p05
Chandra, P., Shufyani, F., Athaillah, A., Ginting, O. S. Br., & Nasution, M. (2023). Formulasi Dan Evaluasi Sediaan Emulgel Ekstrak Etanol Dari Serai (Cymbopogon citratus) Terhadap Bakteri Propionibacterium acne. Forte Journal, 3(2), 158–166. https://doi.org/10.51771/fj.v3i2.631
Chirilă, L., Stan, M. S., Olaru, S., Popescu, A., Lite, M.-C., Toma, D., & Voinea, I. C. (2024). Novel Collagen-Based Emulsions Embedded with Palmarosa Essential Oil, and Chamomile and Calendula Tinctures, for Skin-Friendly Textile Materials. Materials, 17(15), 3867. https://doi.org/10.3390/ma17153867
Dangol, S., Poudel, D. K., Ojha, P. K., Maharjan, S., Poudel, A., Satyal, R., Rokaya, A., Timsina, S., Dosoky, N. S., Satyal, P., & Setzer, W. N. (2023). Essential Oil Composition Analysis of Cymbopogon Species from Eastern Nepal by GC-MS and Chiral GC-MS, and Antimicrobial Activity of Some Major Compounds. Molecules, 28(2), 543. https://doi.org/10.3390/molecules28020543
Erliyanti, N. K., & Pujiastuti, C. (2020). Karakteristik Densitas Dan Indeks Bias Minyak Atsiri Daun Jambu Kristal (Psidium Guajava) Menggunakan Metode Microwave Hydrodistillation Dengan Variabel Daya Dan Rasio Bahan: Pelarut. Jurnal Rekayasa Mesin, 11(2), 247–255. https://doi.org/10.21776/ub.jrm.2020.011.02.11
Jain, A. (2023). Emulgel Approach to Formulation Development: A Review. Asian Journal of Pharmaceutical and Clinical Research, 16(3), 1–7.
Kute, S. B. (2023). Emulsified Gel: A Novel Approach for Delivery of Hydrophobic Drugs—An Overview. Journal of Advanced Pharmaceutical Technology & Research, 14(1), 1–10.
Lambers, H., Piessens, S., Bloem, A., Pronk, H., & Finkel, P. (2006). Natural skin surface pH is on average below 5, which is beneficial for its resident flora. International Journal of Cosmetic Science, 28(5), 359–370. https://doi.org/10.1111/j.1467-2494.2006.00344.x
Puspitasari, R. A., Putri, D. A., & Widyaningsih, T. S. (2022). Characterization of Palmarosa Essential Oil as an Active Ingredient in Natural Cosmetics. Jurnal Teknologi Farmasi Indonesia, 45–52.
Rauf, J., Isa, I., & Thomas, N. A. (2021). Formulasi Sediaan Emulgel Ekstrak Daun Kelor (Moringa oleifera Lam) Dan Uji Aktivitas Antioksidan Menggunakan Metode DPPh. Indonesian Journal of Pharmaceutical Education, 1(1), 10–19. https://doi.org/10.37311/ijpe.v1i1.9947
Rinaldi, Fauziah, F., & Zakaria, N. (2021). Studi formulasi sediaan gel ekstrak etanol serai wangi (Cymbopogon nardus (L.) Randle) dengan basis HPMC. Jurnal Ilmiah Farmasi Simplisia, 1(1), 33–42. https://doi.org/10.30867/jifs.v1i1.96
Rogiers, V. (2001). EEMCO Guidance for the Assessment of Transepidermal Water Loss in Cosmetic Sciences. Skin Pharmacology and Physiology, 14(2), 117–128. https://doi.org/10.1159/000056341
Sari, N. P., Aisyah, R., & Mulyani, A. (2023). Physicochemical Evaluation of Palmarosa Essential Oil and Its Potential in Topical Formulations. Pharmaceutical Journal of Indonesia, 8(1), 101–108.
Saryanti, D., & Putri Setyadi, I. M. (2022). Optimasi Penggunaan Hpmc Dan Na Cmc Pada Formula Transdermal Patch Ekstrak Etanol Bunga Telang (Clitoria ternatea L.) Dengan Metode Simplex Lattice Design. Jurnal Riset Kefarmasian Indonesia, 4(3), 289–305. https://doi.org/10.33759/jrki.v4i3.224
Shakeel, F. (2021). Formulation and Evaluation of a Novel Nanoemulgel Containing Palmarosa Essential Oil for Topical Delivery. Journal of Drug Delivery Science and Technology.
Shakeel, F., Haq, N., Alanazi, F. K., & Alsarra, I. (2019). Recent updates on the stability of emulsion systems: An overview. Critical Reviews in Therapeutic Drug Carrier Systems, 36(5).
Sundari, P., & Puspitasari, D. (2024). Formulation of Nanoemulgel Peel Off Strawberry Fruit Extract (Fragaria x ananassa) and Palmarosa Oil (Cymbopogon martinii) as Antibacterial against Propionibacterium acnes. Jurnal Farmasi, 13(2).
Susianti, N., Juliantoni, Y., & Hanifa, N. I. (2021). Optimasi Sediaan Gel Ekstrak Buah Belimbing Wuluh (Averrhoa bilimbi L.) Dengan Variasi Basis Karbopol 940 Dan CMC-Na. Acta Pharmaciae Indonesia : Acta Pharm Indo, 9(1), 44. https://doi.org/10.20884/1.api.2021.9.1.3669
Tăbăcaru, A. (2024). Novel Collagen-Based Emulsions Embedded with Palmarosa Essential Oil for Skin-Friendly Textile Materials." Polymers. Polymers, 16(5).
Tisserand, R., & Young, R. (2014). Essential oil profiles. Dalam Essential Oil Safety (hlm. 187–482). Elsevier. https://doi.org/10.1016/B978-0-443-06241-4.00013-8
Tiwari, D., Verma, A., & Sharma, R. (2020). Development and evaluation of herbal gel formulation using natural polymers. Research Journal of Pharmacy and Technology, 13, 655–659. https://doi.org/10.5958/0974-360X.2020.00122.3
Utami, N., Yety Lindawati, N., & Karunia Kristy, T. (2023). Quality Evaluation and Effectiveness of Palmarosa (Cymbopogon martinii var. Motia) Essential oils as repellents against Aedes aegypti. Research Journal of Pharmacy and Technology, 5990–5995. https://doi.org/10.52711/0974-360x.2023.00972
Wani, S. K. (2024). Ormulation, Development and Evaluation of Topical Emulgel of Luliconazole Using Essential Oils. CHCMJ, 13(1), 45–52.
Wulansari, S. A., Umarudin, U., & Sa’diyah, L. (2022). Pengaruh Variasi Jenis dan Konsentrasi Gelling Agent Terhadap Karakteristik Fisik Emulgel Koenzim Q10. Journal of Experimental and Clinical Pharmacy (JECP), 2(2), 161. https://doi.org/10.52365/jecp.v2i2.464.
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