Abnormal Cardiac Electrophysiological Activity in the Suku Anak Dalam Living in A Malaria-Endemic Area
Abstract
Malaria is a life-threatening parasitic disease. Although the annual incidence of the parasite has decreased, malaria continues to be a health concern. The incidence of malaria remains high in tropical regions. The Suku Anak Dalam is the indigenous population of Jambi who live in the tropical forest. With limited access to healthcare, low levels of education, poor socio-economic status, and a nomadic lifestyle, the Suku Anak Dalam are vulnerable to malaria infections. Malaria infections trigger immune responses that cause issues with capillary blood vessels and the heart. Changes in the electrocardiogram are considered indicative of cardiac problems. This study aims to understand the electrocardiogram patterns of the Suku Anak Dalam community living in malaria-endemic areas, in order to support preventive measures regarding cardiac issues in populations residing in such regions. This research employed a descriptive cross-sectional design, utilising accidental sampling of nine adult members of the Suku Anak Dalam community who reside in the forest area of Sungai Terap Jelutih village, Batin XXIV Sub-district, Batanghari Regency, Jambi Province, and who consented to undergo electrocardiogram (ECG) recording. The ECG results were subsequently analysed descriptively by a ECG specialist, and the findings were then summarised. The results of electrocardiogram recordings from nine respondents showed Left Bundle Branch Block, along with signs of anaemia and hypertension. The conclusion is that the presence of Left Bundle Branch Block may be due to malaria infection, which triggers immune disturbances resulting in capillary and cardiac complications. Continuous cardiac examinations are necessary in endemic areas as a preventive measure.
References
Adams, Y., Olsen, R. W., Bengtsson, A., Dalgaard, N., Zdioruk, M., Satpathi, S., … Jensen, A. T. R. (2021). Plasmodium falciparum erythrocyte membrane protein 1 variants induce cell swelling and disrupt the blood-brain barrier in cerebral malaria. Journal of Experimental Medicine, 218(3). https://doi.org/10.1084/JEM.20201266
Agaba, B. B., Rugera, S. P., Mpirirwe, R., Atekat, M., Okubal, S., Masereka, K., … Muwanguzi, E. (2022). Asymptomatic malaria infection, associated factors and accuracy of diagnostic tests in a historically high transmission setting in Northern Uganda. Malaria Journal, 21(1), 1–12. https://doi.org/10.1186/s12936-022-04421-1
Arakawa, C., Gunnarsson, C., Howard, C., Bernabeu, M., Phong, K., Yang, E., … Zheng, Y. (2020). Biophysical and biomolecular interactions of malaria-infected erythrocytes in engineered human capillaries. Science Advances, 6(3). https://doi.org/10.1126/sciadv.aay7243
Aryal, E., Mainali, A., & Aryal, S. (2024). Brugada syndrome following febrile episode caused by malarial infection: a case report. Annals of Medicine & Surgery, 86(8), 4891–4894. https://doi.org/10.1097/ms9.0000000000002286
Badan Pusat Statistik. (2010). Profil Suku Anak Dalam (SAD). (M. Berdikarjaya, SE, Ed.). BADANPUSATSTATISTIK PROVINSI JAMBI.
Bayode, T., & Siegmund, A. (2022). Social determinants of malaria prevalence among children under five years : A cross-sectional analysis of Akure , Nigeria. Scientific African, 16, e01196. https://doi.org/10.1016/j.sciaf.2022.e01196
Bhardwaj, P., Sanadhya, A., Sindhur, A., Setia, S., & Sharma, A. (2024). Complete heart block - A rare complication of severe malaria. IP International Journal of Medical Paediatrics and Oncology, 9(4), 141–143. https://doi.org/10.18231/j.ijmpo.2023.029
Boyette, L. C., & Manna, B. (2018). Physiology, Myocardial Oxygen Demand. StatPearls, 16–19. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/29763072
Buthelezi, M. N., Masia, K. J., Masamba, P., Cedric Simelane, M. B., & Kappo, A. P. (2025). Understanding the interplay of malarial pathogenesis, host immune response and oxidative stress: Implications for disease progression and therapeutic strategies. Aspects of Molecular Medicine, 5(August 2024), 100082. https://doi.org/10.1016/j.amolm.2025.100082
Cazzola, M. (2022). Ineffective erythropoiesis and its treatment. Blood, 139(16), 2460–2470. https://doi.org/10.1182/blood.2021011045
Chan, X. H. S., Win, Y. N., Haeusler, I. L., Tan, J. Y., Loganathan, S., Saralamba, S., … White, N. J. (2020). Factors affecting the electrocardiographic QT interval in malaria: A systematic review and meta-analysis of individual patient data. PLoS Medicine, 17(3), e1003040. https://doi.org/10.1371/journal.pmed.1003040
Clark, I. A., Budd, A. C., Alleva, L. M., & Cowden, W. B. (2006). Human malarial disease: A consequence of inflammatory cytokine release. Malaria Journal, 5, 1–32. https://doi.org/10.1186/1475-2875-5-85
Costedoat-Chalumeau, N., Hulot, J. S., Amoura, Z., Leroux, G., Lechat, P., Funck-Brentano, C., & Piette, J. C. (2007). Heart conduction disorders related to antimalarials toxicity: An analysis of electrocardiograms in 85 patients treated with hydroxychloroquine for connective tissue diseases. Rheumatology, 46(5), 808–810. https://doi.org/10.1093/rheumatology/kel402
Craig, A. G., Khairul, M. F. M., & Patil, P. R. (2012). Cytoadherence and severe malaria. Malaysian Journal of Medical Sciences, 19(2), 5–18.
Day, N. P. J., Hien, T. T., Schollaardt, T., Loc, P. P., Van Chuong, L., Chau, T. T. H., … Ho, M. (1999). The prognostic and pathophysiologic role of pro- and antiinflammatory cytokines in severe malaria. Journal of Infectious Diseases, 180(4), 1288–1297. https://doi.org/10.1086/315016
Fogang, B., Schoenhals, M., Maloba, F. M., Biabi, M. F., Essangui, E., Donkeu, C., … Ayong, L. S. (2024). Asymptomatic carriage of Plasmodium falciparum in children living in a hyperendemic area occurs independently of IgG responses but is associated with a balanced inflammatory cytokine ratio. Malaria Journal , 23(1). https://doi.org/10.1186/s12936-024-05086-8
Gahrn-Hansen, B., & Pedersen, C. (2000). Plasmodium falciparum malaria. Ugeskrift for Laeger, 162(4), 508.
Gupta, S., Gazendam, N., Farina, J. M., Saldarriaga, C., Mendoza, I., López-Santi, R., … Baranchuk, A. (2021). Malaria and the Heart: JACC State-of-the-Art Review. Journal of the American College of Cardiology, 77(8), 1110–1121. https://doi.org/10.1016/j.jacc.2020.12.042
Herweg, B., Barold, S. S., & Vijayaraman, P. (2025). First- and second-degree left bundle branch block and masquerading bundle branch block: Lessons learned during conduction system pacing. Heart Rhythm, 1–8. https://doi.org/10.1016/j.hrthm.2025.01.020
Jeanne Rini Poespoprodjo, Nicholas M Douglas, Daniel Ansong, Steven Kho, N. M. A. (2023). Malaria (p. 18). Elsevier. https://doi.org/https://doi.org/10.1016/S0140-6736(23)01249-7
Jensen, A. R., Adams, Y., & Hviid, L. (2020). Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it. Immunological Reviews, 293(1), 230–252. https://doi.org/10.1111/imr.12807
Jurusan, D., Politik, P., & Fitria, L. (2022). Pandangan suku anak dalam terhadap partai politik islam kecamatan mestong kabupaten muaro jambi.
Kalsum, U., Lesmana, O., & Pertiwi, D. R. (2019). Pola Penyakit Tidak Menular dan Faktor Risikonya pada Suku Anak Dalam di Desa Nyogan Provinsi Jambi. Media Kesehatan Masyarakat Indonesia, 15(4), 338. https://doi.org/10.30597/mkmi.v15i4.7062
Kumpitak, C., Duangmanee, A., Thongyod, W., Rachaphaew, N., Suansomjit, C., Manopwisedjaroen, K., … Bantuchai, S. (2024). Human-to-Anopheles dirus mosquito transmission of the anthropozoonotic malaria parasite, Plasmodium knowlesi. Parasites & Vectors, 17(1), 415. https://doi.org/10.1186/s13071-024-06500-5
Langdon, A., Abdlaziz, I., Rhodes, K., & Clarke, J. (2022). Case of myocarditis secondary to severe Plasmodium falciparum infection. BMJ Case Reports, 15(11), 5–8. https://doi.org/10.1136/bcr-2022-249363
Listautin, L., & Nurzia, N. (2020). Strategi Komunikasi dan Pelayanan Kader Kesehatan terhadap Pencegahan Penyakit Menular pada Komunitas Suku Anak dalam di Kabupaten Batanghari Provinsi Jambi. Jurnal Ilmiah Universitas Batanghari Jambi, 20(1), 21. https://doi.org/10.33087/jiubj.v20i1.795
Lubiana, P., Bouws, P., Roth, L. K., Dörpinghaus, M., Rehn, T., Brehmer, J., … Metwally, N. G. (2020). Adhesion between P. falciparum infected erythrocytes and human endothelial receptors follows alternative binding dynamics under flow and febrile conditions. Scientific Reports, 10(1), 1–14. https://doi.org/10.1038/s41598-020-61388-2
Miura, S., Naya, M., & Yamashita, T. (2020). Iron Deficiency Anemia-Induced Cardiomyopathy With Congestive Heart Failure. JACC: Case Reports, 2(11), 1806–1811. https://doi.org/10.1016/j.jaccas.2020.07.051
Muriuki, J. M., Mentzer, A. J., Mitchell, R., Webb, E. L., Etyang, A. O., Kyobutungi, C., … Atkinson, S. H. (2021). Malaria is a cause of iron deficiency in African children. Nature Medicine, 27(4), 653–658. https://doi.org/10.1038/s41591-021-01238-4
Nzoumbou-boko, R., Cornelia, M., Denissio, I., Nalingbo, M., Yambiyo, B. M., Detol, R., … Ii, Y. B. (2025). Subclinical Plasmodium spp . Infections in a Community Setting in Bangui , Central African Republic, (January), 1–10.
Olatunji, G., Kokori, E., Ogieuhi, I. J., Akinmoju, O., Omoworare, O., Olatunji, D., … Egbunu, E. (2025). Myocarditis in malaria — current evidence and future directions : a literature review. The Egyptian Journal of Internal Medicine. https://doi.org/10.1186/s43162-024-00396-4
Oleinikov, A. V., Seidu, Z., Oleinikov, I. V., Tetteh, M., Lamptey, H., Ofori, M. F., … Lopez-Perez, M. (2024). Profiling the Plasmodium falciparum Erythrocyte Membrane Protein 1-Specific Immununoglobulin G Response among Ghanaian Children with Hemoglobin S and C. Journal of Infectious Diseases, 229(1), 203–213. https://doi.org/10.1093/infdis/jiad438
Pereira, A. A., & Sarnak, M. J. (2003). Anemia as a risk factor for cardiovascular disease. Kidney International, Supplement, 64(87), 1–2. https://doi.org/10.1046/j.1523-1755.64.s87.6.x
Popa, G. L., & Popa, M. I. (2021). Recent Advances in Understanding the Inflammatory Response in Malaria: A Review of the Dual Role of Cytokines. Journal of Immunology Research, 2021(Figure 1), 10–12. https://doi.org/10.1155/2021/7785180
Putri, N. A., & Ariusmedi, A. A. (2023). Suku anak dalam sebagai inspirasi penciptaan karya seni grafis dengan teknik cetak tinggi. Serupa The Journal of Art Education, 12(3), 230. https://doi.org/10.24036/stjae.v12i3.122444
Romero, D. V. L., Balendran, T., Hasang, W., Rogerson, S. J., Aitken, E. H., & Achuthan, A. A. (2024). Epigenetic and transcriptional regulation of cytokine production by Plasmodium falciparum-exposed monocytes. Scientific Reports, 14(1), 1–10. https://doi.org/10.1038/s41598-024-53519-w
Sauer, L. M., Canovas, R., Roche, D., Shams-Eldin, H., Ravel, P., Colinge, J., … Cornillot, E. (2023). FT-GPI, a highly sensitive and accurate predictor of GPI-anchored proteins, reveals the composition and evolution of the GPI proteome in Plasmodium species. Malaria Journal, 22(1), 1–19. https://doi.org/10.1186/s12936-022-04430-0
Sheikh Jan, M., Mohammad Tahir, G., Samiera, H., & Nusrat, B. (2020). Incidence of Left Ventricular Systolic Dysfunction in Asymptomatic, Incidently Detected Left Bundle Branch Block (LBBB) in Apparently Healthy Individuals: A Prospective Observational Study at a Tertiary Care Cardiac Center in North India. International Journal of Clinical Cardiology, 7(6), 1–7. https://doi.org/10.23937/2378-2951/1410211
Suryaman, A., Anwar, C., Handayani, D., Saleh, I., Dalillah, D., Prasasty, G. D., … Warni, S. E. (2021). Malaria Surveillance in the Anak Dalam Tribe, Jambi, Indonesia. Jurnal Ilmu Kesehatan Masyarakat, 12(2), 104–116. https://doi.org/10.26553/jikm.2021.12.2.104-116
Suryaman, A., Anwar, C., Handayani, D., Warni, S. E., Saleh, I., Dalillah, D., & Prasasty, G. D. (2020). Prevalensi Malaria Pada Daerah Endemis Orang Rimba Provinsi Jambi Menggunakan Pemeriksaan Mikroskopis. Jurnal Bahana Kesehatan Masyarakat (Bahana of Journal Public Health), 4(1), 1–4. https://doi.org/10.35910/jbkm.v4i1.265
Tan, N. Y., Witt, C. M., Oh, J. K., & Cha, Y. M. (2020). Left Bundle Branch Block: Current and Future Perspectives. Circulation: Arrhythmia and Electrophysiology, 13(4), E008239. https://doi.org/10.1161/CIRCEP.119.008239
Vyas, N., Hendren, S., Tushar Sehgal, D. M., Monga, C., Ranjan, R., Chaturvedi, H., … Vashistha, V. (2023). The Accuracy of Physical Examination to Diagnose Anemia Among Patients Five Years or Older: A Systematic Review. Indian Journal of Hematology and Blood Transfusion, 39(1), 90–101. https://doi.org/10.1007/s12288-022-01543-z
Warner, M. J., & Kamran, M. T. (2023). Iron Deficiency Anemia Pathophysiology Histopathology. National Institutes of Health, 1–6. Retrieved from https://www.ncbi.nlm.nih.gov/books/NBK448065/
Zhang, C., Sorchampa, S., Zhou, H., Jiang, J., Yang, R., & Zhang, Y. (2020). Survey of asymptomatic malaria and mosquito vectors in Muang Khua District of Phongsaly Province, China–Laos Border. International Journal of Infectious Diseases, 96, 141–147. https://doi.org/10.1016/j.ijid.2020.03.066.
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