Factors that Influence Medication Compliance in Pulmonary Tuberculosis Patients

  • Bayu M.A Nugroho Universitas Islam Sultan Agung
  • Conita Yuniarifa Universitas Islam Sultan Agung
  • Kamilia Dwi Utami Universitas Islam Sultan Agung
Keywords: compliance, education, health center, pulmonary tuberculosis, support

Abstract

Pulmonary tuberculosis is a chronic infectious disease that has a significant impact on global health, including Indonesia. Bandar I Health Center, Batang Regency was chosen as the research location because it has a low complete rate of taking medication (29.09%). Objective to analyze factors that influence medication compliance in pulmonary tuberculosis patients, including knowledge, attitudes, access to health services, drug side effects, family support, and support from health workers. An analytical observational design with a cross-sectional method. Data were collected through questionnaires from 68 pulmonary tuberculosis patients who met the inclusion criteria. Bivariate analysis used the Chi-Square test to determine the relationship between each independent variable and compliance, while multivariate analysis was performed to determine the dominant influencing factors. The knowledge, attitude, family support, and health worker support had a significant relationship with patient compliance (p < 0.05). Health worker support was a dominant factor with an Exp(B) value of 28.7, which means that patients with good health worker support have a 28.7 times greater chance of compliance. In contrast, access to health services did not show a significant relationship (p > 0.05).  The compliance of tuberculosis patient’s is influenced by education, positive attitude, family support, and attention from health workers. Interventions focused on strengthening patient education and increasing support from health workers are recommended to improve the success of tuberculosis treatment.

References

Adhanty, S., & Syarif, S. (2023). Medication Compliance in Tuberculosis Patients and Factors Affecting It: A Systematic Review. Indonesian Journal of Health Epidemiology, 7(1). https://doi.org/https://doi.org/10.7454/epidkes.v7i1.6571

Adima, F., & Arini, M. (2025). The influence of healthcare workers’ social support on compliance to medication in multidrug resistant tuberculosis patients at the Regional General Hospital of Dr. Saiful Anwar. Clinical Epidemiology and Global Health, 31(101890). https://doi.org/10.1016/j.cegh.2024.101890

Adisa, R., Ayandokun, T. T., & Ige, O. M. (2021). ’Knowledge about tuberculosis, treatment adherence and outcome among ambulatory patients with drugsensitive tuberculosis in two directly-observed treatment centers in Southwest Nigeria. BMC Public Health, 21(1), 1–14. https://doi.org/10.1186/s12889-021-10698-9

Andira, B. P., Dahliah, D., Wiriansya, E. P., Irwan, A. A., & Hamzah, P. N. (2024). The Relationship between Side Effects of Anti-Tuberculosis Drugs (OAT) and Treatment Compliance in Tuberculosis Patients at Jongaya Health Center Makassar. Wal’afiat Hospital Journal, 5(1), 48–59. https://doi.org/https://doi.org/10.33096/whj.v5i1.134

Dachi, S., Dachi, R. A., Sitorus, M. E. J., Nababan, D., & Tarigan, F. L. (2024). Factors Related to Compliance in Taking Anti-Tuberculosis Drugs (OAT) in Pulmonary TB Patients in the Work Area of the Lahomi Health Center, Lahomi District, West Nias Regency. PREPOTIF: Journal of Public Health, 8(1), 816–843.

Dinas Kesehatan Kabupaten Batang. (2020). Profil Kesehatan Kabupaten Batang Tahun 2020. https://doi.org/https://dinkes.batangkab.go.id/wpcontent/uploads/2022/06/1.-Profil-Dinkes-2020.pdf

Fatmawati, F., Tasalim, R., Riduansyah, M., & Latifah, L. (2023). Efektivitas Psikoedukasi terhadap Peningkatan Self-Efficacy dan Kepatuhan Minum Obat Antihipertensi. Jurnal Keperawatan, 15(2), 577–586. https://doi.org/10.32583/keperawatan.v15i2.961

Gashu, K. D., Gelaye, K. A., & Tilahun, B. (2021). Adherence to TB treatment remains low during continuation phase among adult patients in Northwest Ethiopia. BMC Infectious Diseases, 21(1), 1–10. https://doi.org/doi: 10.1186/s12879-021-06428-6

Highsmith, H. Y., Starke, J. R., & Mandalakas, A. M. (2019). Tuberculosis. In Kendig’s Disorders of the Respiratory Tract in Children. https://doi.org/https://doi.org/10.1016/B978-0-323-44887-1.00029-8

Kemenkes RI. (2020). Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. Jakarta: Kementerian Kesehatan RI.

Kementerian Kesehatan RI. (2018). Riset Kesehatan Dasar. http://labdata.litbang.depkes.go.id/riset-badan-litbangkes/menuriskesnas/menu-riskesdas

Kementerian Kesehatan RI. (2022). Program Pengendalian Tuberkulosis. https://tbindonesia.or.id/wp-content/uploads/2023/09/Laporan-Tahunan-Program-TBC-2022.pdf

Mekonnen, H. S., & Azagew, A. W. (2018). ’Non-adherence to anti-tuberculosis treatment, reasons and associated factors among TB patients attending at Gondar town health centers, Northwest Ethiopia. BMC Research Notes, 11(1), 1–8. https://doi.org/10.1186/s13104-018-3789-4

Pangestika, R., Fadli, R. K., & Alnur, R. D. (2019). Education on Prevention of TB Disease Transmission through Household Contacts. SOLMA Journal. https://doi.org/https://doi.org/10.29405/solma.v8i2.3258

Rosadi, D. (2020). Factors Related to Pulmonary Tuberculosis Patient Compliance with Anti-Tuberculosis Drugs. Periodical Journal of Health, 6(2). https://doi.org/https://doi.org/10.20527/jbk.v6i2.9452

Sahputri, J., & Khairunnisa, C. (2022). Factors Related to Adherence to Taking Anti-Tuberculosis (OAT) Drugs in Pulmonary Tuberculosis Patients at Cut Meutia General Hospital, North Aceh Regency. Indonesian Journal of Medical Reviews, 2(5), 294–298.

Samory, U. S., Yunalia, E. M., & Suharto, I P S Nurseskasatmata, S. (2022). Factors Related to Patient Compliance in Taking Pulmonary Tuberculosis Medication at Urei-Faisei Health Center (URFAS). Indonesian Health Science Journal, 2(1). https://doi.org/https://doi.org/10.52298/ihsj.v2i1.25

Sofiana, L., Ayu, S. M., Amelia, D., Adiningsih, P., Sa’diyah, U., Putri, N., Azizah, A. R., & Safitri, A. A. (2022). Medication Adherence of Tuberculosis Patients in Yogyakarta: A Cross Sectional Study. Journal of Health Education, 7(2), 95–106.

Sriyanah, N., Efendi, S., Ilyas, H., & Nadira, N. (2022). Hubungan Pengetahuan, Sikap dengan Dukungan Keluarga sebagai Pengawas Kepatuhan Minum Obat Penderita Tuberkulosis Paru. An Idea Health Journal, 2(02), 87–92.

Sugiyanto, S., & Sigala, A. (2023). Analysis of the Role of Family Support in Treatment Compliance of Pulmonary Tuberculosis Clients. Tropical Health and Medical Research, 5(2), 113–119. https://doi.org/doi: 10.35916/thmr.v5i2.89

Tang, Y., Zhao, M., Wang, Y., Gong, Y., Yin, X., Zhao, A., Zheng, J., Liu, Z., Jian, X., Wang, W., Wu, C., & Lu, Z. (2015). Non-adherence to anti-tuberculosis treatment among internal migrants with pulmonary tuberculosis in Shenzhen, China: A cross-sectional study. BMC Public Health, 15(1), 1–6. https://doi.org/doi: 10.1186/s12889-015-1789-z

Tukayo, I. J. H., Hardyanti, S., & Madeso, M. S. (2020). Factors Affecting Compliance in Taking Anti-Tuberculosis Drugs in Patients Pulmonary Tuberculosis at Waena Health Center. Papua Tropical Nursing Journal, 3(1). https://doi.org/https://doi.org/10.47539/jktp.v3i1.104

WHO. (2020). WHO | Global tuberculosis report 2019. World Health Organization. https://doi.org/.1037//0033-2909.I26.1.78

Woimo, T. T., Yimer, W. K., Bati, T., & Gesesew, H. A. (2017). The prevalence and factors associated for antituberculosis treatment non-adherence among pulmonary tuberculosis patients in public health care facilities in South Ethiopia: a cross-sectional study. BMC Public Health, 17(1), 269. https://doi.org/doi: 10.1186/s12889-017-4188-9.

Wulandari, I. S. M., Rantung, J., & Malinti, E. (2020). Factors Related to Compliance in Taking TB Patients’ Medication in the Parongpong Health Center Work Area. Muhammadiyah Nursing Journal, 5(1). https://doi.org/https://doi.org/10.30651/jkm.v5i1.4536

Published
2025-08-01
How to Cite
Nugroho, B. M., Yuniarifa, C., & Utami, K. D. (2025). Factors that Influence Medication Compliance in Pulmonary Tuberculosis Patients. Indonesian Journal of Global Health Research, 7(4), 445-452. https://doi.org/10.37287/ijghr.v7i4.5884