Basics of Stem Cells Therapy
Abstract
Regeneration of a lost tissue is known to be great challenge for several years, in the recent past the research on regenerative medicine has gained great importance and scientific advancements in the field of molecular biology. Understanding the biological concepts in the tissue regeneration coupled with experiments on stem cells is likely to result in a great shift in the therapeutic medicine. Stem cells have been successfully isolated from variety of human tissues. Initial evidence from pioneering studies has documented that stem cells play vital role in treatment for various life-threatening diseases that have so far defeated modern medical care. The recent studies have been exploring the role of stem cells and their applications. This review discusses in brief the origin of stem cells, their properties, characteristics. It also focuses on current research, their potential applications and the various challenges and barriers that we must overcome before translating laboratory results to successful clinical applications.
References
Atef Nazmy Boulos1 , Amany Mahmoud Ali El-Agawany1 , Aleya Esmael Mohamed Awwad1 , Ghada Mohamed Mourad Fouad2 and Abeer Gaber Ahmed Mohamed Abd El-Rahman1. The Effect of Bone Marrow Mesenchymal Stem Cells on Experimentally-Induced Gastrocnemius Muscle Injury in Female Albino Rats. EJH. 2021; 44_Issue 1_Pages 218-235
Beer L, Mildner M, Ankersmit HJ. Cell secretome based drug substances in regenerative medicine: when regulatory affairs meet basic science. Ann Transl Med. 2017;5 (7):1-3.
Daley GQ, Scadden DT. Prospects for stem cell-based therapy. Cell. 2008;132:544–8. [PubMed] [Google Scholar]
Fuchs JR, Hannouche D, Terada S, Zand S, Vacanti JP, Fauza DO. Cartilage engineering from ovine umbilical cord blood mesenchymal progenitor cells. Stem Cells. 2005;23:958–64. [PubMed] [Google Scholar]
Gater R, Nguyen D, Haj AJE, Yang Y. Development of Better Treatments for Retinal Disease Using Stem Cell Therapies. Int J Stem Cell Res Ther. 2016; 3: 1-6.
Heba E. Abd El-Halim, Omayma K. Helal, Nessrein E. Salem, Nahla E. El-Azab. The Possible Therapeutic Effect of Mesenchymal Stem Cells and their Exosomes on Experimentally Induced Diabetic Retinopathy in Rats: Histological and Immunohistochemical Study. EJH. 2020; 43_Issue 2_Pages 390-411
Jacquelyn C. Stem cell transplant . Mayo Clinic Staff. 2017 (mayoclinic.org/tests-procedures/stem-cell-transplant/in-depth/stem-cells/ART-20048117?p=1)
Jeon YJ, Kim J, Cho JH, Chung HM, Chae JI. Comparative Analysis of Human Mesenchymal Stem Cells Derived From Bone Marrow, Placenta, and Adipose Tissue as Sources of Cell Therapy. J Cell Biochem 2016;117(5):1112-25.
Kourembanas, S. Exosomes: vehicles of intercellular signaling, biomarkers, and vectors of cell therapy. Annu. Rev. Physiol 2015; 77: 13–27.
Luna AC, Madeira ME, Conceicao TO, Moreira JA, Laiso RA, Maria DA. Characterization of adipose-derived stem cells of anatomical region from mice. BMC Res Notes 2014;7:552.
Mathiasen AB, Qayyum AA, Jørgensen E, Helqvist S, Fischer-Nielsen A, Kofoed KF, et al. Bone marrow-derived mesenchymal stromal cell treatment in patients with severe ischaemic heart failure: a randomized placebo-controlled trial (MSC-HF trial). Eur Heart J 2015;36(27):1744-53
Mohamed-Ahmed S, Fristad I, Lie SA, Suliman S, Mustafa K, Vindenes H, et al. Adiposederived and bone marrow mesenchymal stem cells: a donor-matched comparison. Stem Cell Res Ther 2018;9(1):168.
Mona A. Barkat1, Melad N. Kelada1, Iman Nabil2 , Doaa A.Abdelmonsif , Abeer E. Dief, et al. The potential Therapeutic Effect of Adipose Tissue-derived Mesenchymal Stem Cell Transplantation on Cuprizone Model of Multiple Sclerosis in the Mice. EJH. 2020; 43_Issue 1_Pages 122-143
Omayma K. Helal, Aisha EL. Mansy, Ola M. Mohamed and Hala El. Ahmed Radwan. The Possible Therapeutic Effect of Rebamipide and Stem Cell Derivative Microvesicles on Experimentally Provoked Colitis in Rats: Histological and Immuno Hisochemical Study. EJH. 2019; 43_Issue 1_Pages 340-352
Rashed M, Bayraktar E, K Helal G, Abd-Ellah MF, Amero P, Chavez-Reyes A, Rodriguez-Aguayo C. Exosomes: From Garbage Bins to Promising Therapeutic Targets. Int J Mol Sci. 2017; 18(3): 1-25.
Rehab A Abdel Moneim1,2, Abeer Mostafa3 , Marwa MS Abbass. In Treating Glucocorticoids Induced Osteoporosis in Temporomandibular Joint of Albino Rats; Which are More Effective Microvesicles or Mesenchymal Stem Cells? EJH. 2020; 43_Issue 3_Pages 849-862
Sayed AA, EL-Deek SEM, EL-Baz MA, Sabry D, Rageaey A, Mansy A, Meligy FY, Abdelaziz k.(): Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Restore Cisplatin Induced Ovarian Damage by Promoting Stem Cell Survival, Meiotic, and Apoptotic Marker. Global Advanced Research Journal of Medicine and Medical Sciences 2017; 6 (6):116-130.
Shefaa M. F El Sawy1 , Moushira Ahmed Zoheir1 , Iman Nabil1 , Doaa Ali Abdelmonsif2 , Heba Hamed1. Differentiation of Bone Marrow-derived Mesenchymal Stem Cells into Cardiomyocytes Using Different Regimens of 5- Azacytidine. EJH.2020; 43_Issue 2_Pages 569-584
Squillaro T, Peluso G, Galderisi U. Clinical Trials with Mesenchymal Stem Cells: An Update. Cell Transplant. 2016 May;25(5):829–48.
Tateishi K, Takehara N, Matsubara H, Oh H. Stemming heart failure with cardiac- or reprogrammed-stem cells: Stem cells review series. J Cell Mole Med. 2008;12:2217–32. [PMC free article] [PubMed] [Google Scholar]
Wehmeyer J, Zaiss M, Losem C, Schmitz S, Niemeier B, Harde J, et al. Impact of performance status and transfusion dependency on outcome of patients with myelodysplastic syndrome, acute myeloid leukemia and chronic myelomonocytic leukemia treated with azacitidine (PIAZA study). Eur J Haematol 2018;101(6):766-73.
Yin K, Wang S. and Zhao RC. Exosomes from mesenchymal stem /stromal cells: a new therapeutic paradigm. Biomark Res. 2019; 7:1-8.
Yolanda MM, Maria AV, Amaia FG, Marcos PB, Silvia PL, Dolores E. and Jesús O. Adult stem cell therapy in chronic wound healing. J. Stem Cell Res. Ther. 2014; 4 (1): 1-6.
Yu B, Shao H, Su C, Jiang Y, Chen X, Bai L, Zhang Y, Li Q, Zhang X, & Li X. Exosomes derived from MSCs ameliorate retinal laser injury partially by inhibition of MCP-1. Sci Rep. 2016;(6): 1-12.
Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood 2005;106(5):1755-61.
