Overview of Dry Eye Severity in Diabetic Retinopathy Patients

  • Fatihah Annisa Humaira Universitas Andalas
  • Havriza Vitresia Universitas Andalas
  • Noverial Noverial Universitas Andalas
Keywords: diabetes mellitus, diabetic retinopathy, dry eye, ferning, OSDI

Abstract

Dry eye is often found in patients with diabetes mellitus. One of the microvascular complications of diabetes mellitus is diabetic retinopathy. Dry eye in diabetic retinopathy patients is caused by chronic hyperglycaemia which causes microvascular and nerve damage resulting in decreased tear secretion and hyperosmolarity and activates inflammatory mediators that can damage conjunctival goblet cells and decrease mucin secretion. Objective: This study aims to determine the description of dry eye severity through the OSDI scoring system and ferning test in diabetic retinopathy patients based on its degree. Method: This study uses a descriptive method with a cross sectional design. The number of samples in the study were 64 people with a diagnosis of diabetic retinopathy. The sampling technique in this study was carried out by consecutive sampling. Result: The study was conducted using the OSDI questionnaire and ferning test examination on samples that had been diagnosed with diabetic retinopathy based on predetermined inclusion and exclusion criteria. The research data were compiled using Microsoft Excel and then reviewed for completeness. Then the complete data was processed using a computer programme, namely the Statistical Package for Social Sciences (SPSS). The results obtained from this research are most patients were female (64.1%), aged 45-65 years (79.7%), diabetes mellitus duration >5 years (60.9%). The most common degree of retinopathy with dry eye was PDR (64.1%). The most common degree of dry eye and type of ferning was severe dry eye (62.5%) and type IV (59.4%) which mostly occurred in patients with PDR. Conclusions:  Based on the OSDI score and ferning test in the study conducted on diabetic retinopathy patients based on the degree, all patients had dry eye (100%).

References

Abigail, M., Wildan, A., & Johan, A. (2016). Perbedaan Tear Film Break Up Time pada Pasien Retinopati Diabetika Non Proliferatif Dibandingkan Retinopati Diabetika Proliferatif. Jurnal Kedokteran Diponegoro, 5(4), 1261–1268.

Abusharha, A., El-Hiti, G. A., Alsubaie, M. H., Munshi, A. F., Alnasif, A. R., Fagehi, R., Alanazi, M. A., & Masmali, A. M. (2022). Evaluation of Tear Evaporation Rate in Patients with Diabetes Using a Hand-Held Evaporimeter. Healthcare, 10(1), 1–8.

American Academy Ophthalmology. (2019). External Disease and Cornea 2019-2020 Basic and Clinical Science Course (BCSC). San Francisco: American Academy Ophthalmology.

American Diabetes Association. (2010). Diagnosis and Classification of Diabetes Mellitus. Diabetes Care, 33 Suppl 1(Suppl 1), S62–S69.

Betteng, R., Pangemanan, D., & Mayulu, N. (2014). Analisis Faktor Risiko Penyebab Terjadinya Diabetes Melitus Tipe 2 pada Wanita Usia Produktif di Puskesmas Wawonasa. Jurnal e-Biomedik, 2(2), 404–412.

Bitton E. (2007). Tear ferning : a valuable tool in determining dry eye. Optician, 32–35.

Bron, A. J., de-Paiva, C. S., Chauhan, S. K., Bonini, S., Gabison, E. E., Jain, S., Knop, E., Markoulli, M., Ogawa, Y., Perez, V., Uchino, Y., Yokoi, N., Zoukhri, D., & Sullivan, D. A. (2017). TFOS DEWS II Pathophysiology Report. The Ocular Surface, 15(3), 438–510.

Craig, J. P., Nelson, J. D., Azar, D. T., Belmonte, C., Bron, A. J., Chauhan, S. K., de-Paiva, C. S., Gomes, J. A. P., Hammitt, K. M., Jones, L., Nichols, J. J., Nichols, K. K., Novack, G. D., Stapleton, F. J., Willcox, M. D. P., Wolffsohn, J. S., & Sullivan, D. A. (2017). TFOS DEWS II Report Executive Summary. The Ocular Surface, 15(4), 802–812.

Devi, R. S. U., & Gowda, M. S. S. (2016). Dry Eye in Diabetes Mellitus Patients and its Relationship with Diabetic Retinopathy. International Journal of Scientific Study, 4(8), 67–72.

Dewi, P. N., Fadrian, & Vitresia, H. (2019). Profil Tingkat Keparahan Retinopati Diabetik Dengan Atau Tanpa Hipertensi pada di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 8(2), 204–210.

Foulks, G. N., Lemp, M. A., Jester, J. V., Sutphin, J., Jr., Murube, J., Novack, G. D., Erickson, S., Brookline, Abelson, M. B., Asbell, P. A., Baudouin, C., Beuerman, R. W., Bonini, S., Bron, A., Dana, M. R., Dartt, D. A., Dua, H. S., Fleiszig, S. M. J., Fonn, D., . . . Wilson, G. (2007). Report of the International Dry Eye WorkShop (DEWS). The Ocular Surface, 5(2), 65–204.

Fuerst, N., Langelier, N., Massaro-Giordano, M., Pistilli, M., Stasi, K., Burns, C., Cardillo, S., & Bunya, V. Y. (2014). Tear osmolarity and dry eye symptoms in diabetics. Clinical Ophthalmology, 8, 507–515.

Han, J. X., Wang, H., Liang, H. H., & Guo, J. X. (2021). Correlation of the retinopathy degree with the change of ocular surface and corneal nerve in patients with type 2 diabetes mellitus. Int J Ophthalmol, 14(5), 750–758.

Ilery, T., Sumual, V., & Rares, L. (2014). Prevalensi Retinopati Diabetik pada Poliklinik Ilmu Kesehatan Mata Selang Satu Tahun. e-Clinic, 2(1), 1–9.

Iskandar, F. (2020). Diquafosol Tetrasodium: Tatalaksana Terkini untuk Dry Eye Disease (DED). CDK Journal-288, 47(7), 542–546.

Kaiserman, I., Kaiserman, N., Nakar, S., & Vinker, S. (2005). Dry Eye in Diabetic Patients. American Journal of Ophthalmology, 139(3), 498–503.

Khurana, G., Khurana, D., & Jain, R. (2017). Dry Eye in Patients With Diabetic Retinopathy: A Clinical Study. Delhi Journal Ophthalmology, 27(3), 190–193.

Klein, R., Klein, B. E. K., Moss, S. E., Davis, M. D., & de-Mets, D. L. (1984). The Wisconsin Epidemiologic Study of Diabetic Retinopathy: Prevalence and Risk of Diabetic Retinopathy When Age at Diagnosis Is Less Than 30 Years. Arch Ophthalmol, 102(4), 520–526.

Legoh, C. G. F., Setiono, K. W., & Cahyaningsih, E. (2019). Hubungan Lama Menderita Diabetes dengan Dry Eye pada Penderita Diabetes Melitus Tipe II di RSUD Prof. Dr.W.Z Johannes Kupang. Cendana Medical Journal (CMJ), 18(3), 364–370.

Lukandy, A., & Albar, M. Y. (2020). Prevalensi dry eye pada pasien diabetes melitus tipe 2 di Rumah Sakit Mata Mencirim 77 Kota Medan. Intisari Sains Medis 2020, 11(3), 1193–1197.

Manullang, Y. R., Rares, L., & Sumual, V. (2016). Prevalensi Retinopati Diabetik pada Penderita Diabetes Melitus di Balai Kesehatan Mata Masyarakat (BKMM) Propinsi Sulawesi Utara Periode Januari-Juli 2014. E-Clinic, 4(1), 1–6.

Masmali, A. M., Al-Qhtani, S., Al-Gasham, T. M., El-Hiti, G. A., Purslow, C., & Murphy, P. J. (2015). Application of a new grading scale for tear ferning in non-dry eye and dry eye subjects. Contact Lens & Anterior Eye, 38(1), 39–43.

Masmali, A. M., Maeni, Y. A., El-Hiti, G. A., Murphy, P. J., & Almubrad, T. (2017). Investigation of Ocular Tear Ferning in Controlled and Uncontrolled Diabetic Subjects. Eye & Contact Lens, 44, S70–S75.

Masmali, A. M., Purslow, C., & Murphy, P. J. (2014). The tear ferning test: a simple clinical technique to evaluate the ocular tear film. Clinical and Experimental Optometry, 97(5), 399–406.

Nadeem, H., Malik, T. G., Mazhar, A., & Ali, A. (2020). Association of Dry Eye Disease with Diabetic Retinopathy. Journal of the College of Physicians and Surgeons Pakistan, 30(05), 493–497.

Oktavian, L. I., Supono, T. S., & Suharno. (2011). Korelasi Kadar Glikohemoglobin (HbA1c) dengan Kuantitas Sekresi Air Mata pada Pasien Diabetes Melitus Studi di RSUD Margono Soekarjo. Mandala of Health, 5(3), 390–394.

Okumura, Y., Inomata, T., Iwata, N., Sung, J., Fujimoto, K., Fujio, K., Midorikawa-Inomata, A., Miura, M., Akasaki, Y., & Murakami, A. (2020). A Review of Dry Eye Questionnaires: Measuring Patient-Reported Outcomes and Health-Related Quality of Life. Diagnostics, 10(559), 1–21.

Özcura, F., Aydin, S., & Helvaci, M. R. (2007). Ocular Surface Disease Index for the Diagnosis of Dry Eye Syndrome. Ocular Immunology and Inflammation, 15(5), 389–393.

Perkumpulan Endokrinologi Indonesia. (2015). Konsensus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia 2015. Jakarta: PB PERKENI.

Prasetia, T. (2016). Pola Komplikasi Sistemik pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Pertamina Bintang Amin Lampung Periode 1 Januari - 31 Desember 2015. Jurnal Medika Malahayati, 3(1), 55–60.

Rahmadilla, A. P. (2020). Hubungan Pemakaian Lensa Kontak Lunak (Soft Contact Lens) dengan Dry Eye Syndrome. Jurnal Medika Hutama, 02(01), 271–277.

Rajagukguk, C., Santoso, S. A., & Basoeki, S. (2016). Pengaruh Kemoterapi terhadap Sindroma Mata Kering Menggunakan Tes Ferning Okuler. Majalah Kesehatan FKUB, 3(2), 57–64

Salsabila, N., Vitresia, H., & Rustini, R. (2020). Efektivitas Injeksi Intravitreal Anti-VEGF terhadap Tajam Penglihatan pada Pasien Retinopati Diabetik. Jurnal Ilmu Kesehatan Indonesia (JIKESI), 1(2), 125–133.

Schiffman, R. M., Christianson, M. D., Jacobsen, G., Hirsch, J. D., & Reis, B. L. (2000). Reliability and Validity of the Ocular Surface Disease Index. Arch Ophthalmol, 118(5), 615–621.

Sethia, R., Patel, J., Pothuri, N. A., Shah, S., Mehta, J., & Vora, J. (2021). Tear film changes in type II diabetes mellitus with and without diabetic retinopathy. Journal of Clinical and Diagnostic Research, 15(2), p1–p4.

Setiawan, D., Wildan, A., & Johan, A. (2016). Perbedaan Hasil Pengukuran Schirmer Test pada Pasien Retinopati Diabetika Non Proliferatif dan Proliferatif. Diponegoro Medical Journal (Jurnal Kedokteran Diponegoro), 5(4), 694–702.

Setyoputri, N. T., Soelistijo, S. A., & Sasono, W. (2017). Prevalensi dan Karakteristik Pasien Retinopati Diabetik di Poli Mata RSUD Dr. Soetomo. JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga, 9(1), 20–25.

Shaikh, R. (2015). Prevalence of dry eye disease in type 2 diabetic patients and its co-relation with the duration, glycemic control and retinopathy. Al Ameen J Med Sci, 8(3), 225–229.

Singh, A. K., Nagpal, S., & Tyagi, R. (2018). A Study of Tear Ferning Patterns in Elderly Individuals with Dry Eye Disorder. Journal of Clinical and Diagnostic Research, 12(5), NC01–NC04.

Sitompul, R. (2011). Retinopati Diabetik. J Indon Med Assoc, 61(8), 337–341.

Utami, D. R., Amin, R., & Zen, N. F. (2017). Karakteristik Klinis Pasien Retinopati Diabetik Periode 1 Januari 2014 - 31 Desember 2015 di RSUP Dr. Mohammad Hoesin Palembang. Majalah Kedokteran Sriwijaya, 49(2), 66–74.

Wibawa, I. M. S., Budhiastra, P., & Susila, N. K. N. (2018). Karakteristik Pasien Retinopati Diabetik di Rumah Sakit Umum Pusat Sanglah Denpasar Periode April 2016 – April 2017. E-Jurnal Medika, 7(11), 1–6.

Wolffsohn, J. S., Arita, R., Chalmers, R., Djalilian, A., Dogru, M., Dumbleton, K., Gupta, P. K., Karpecki, P., Lazreg, S., Pult, H., Sullivan, B. D., Tomlinson, A., Tong, L., Villani, E., Yoon, K. C., Jones, L., & Craig, J. P. (2017). TFOS DEWS II Diagnostic Methodology Report. The Ocular Surface, 15(3), 539–574.

World Health Organization. (2021). Diabetes, June 2021, (https://www.who.int/news-room/fact-sheets/detail/diabetes).

Yazdani, C., McLaughlin, T., Smeeding, J. E., & Walt, J. (2001). Prevalence of Treated Dry Eye Disease in a Managed Care Population. Clincal Therapeutics, 23(10), 1672–1682.

Published
2024-10-21
How to Cite
Humaira, F. A., Vitresia, H., & Noverial, N. (2024). Overview of Dry Eye Severity in Diabetic Retinopathy Patients. Indonesian Journal of Global Health Research, 6(S5), 405-416. https://doi.org/10.37287/ijghr.v6iS5.4255