Description of Blood Sugar Levels of Male Wistar Rats after Administration of Ethanol Extract of Rambusa Leaves (Passiflora Foetida Linn.) from Central Kalimantan
Abstract
Rambusa (Passiflora foetida Linn.) is a type of plant that is often found creeping on other plants. Usually found in watery areas such as swamps and rivers. The rambusa plant contains chemical compounds which are useful sources and can be developed as medicine. Several previous studies explained that Rambusa (Passiflora foetida Linn.) which grows in several areas shows antidiabetic properties. The aim of this study was to determine the blood sugar levels of male Wistar rats after administration of ethanol extract of rambusa leaves (Passiflora foetida Linn.) from Central Kalimantan. This research was carried out using an experimental or experimental method (experiment research) in the laboratory which was carried out with a series of experiments using the GCU Check strip. The results of this study show that ethanol extract of rambusa leaves from Central Kalimantan can reduce blood sugar levels of male Wistar rats at doses of 1.5 mg/Kgbb and 2 mg/Kgbb.
References
Atun, M. (2010). Diabetes Melitus Memahami, Mencegah, dan Merawat Penderita Penyakit Gula. Bantul: Kreasi Wacana.
Dalimartha, S. (2000). Atlas tumbuhan obat Indonesia (Vol. 2). Niaga Swadaya.
Depkes, R. I. (2005). Pedoman Nasional Etik Penelitian Kesehatan.
Haryono, R., & Setianingsih, S. (2013). Awas Musuh-musuh anda setelah usia 40 tahun. Yogyakarta: Gosyen Publishing.
Herlina, Aziz, S. A., Kurniawati, A., & Faridah, D. N. (2017). Changes of Thymoquinone, Thymol, and Malondialdehyde Content of Black Cumin (Nigella sativa L.) in Response to Indonesia Tropical Altitude Variation. HAYATI Journal of Biosciences, 24(3), 156–161. https://doi.org/10.1016/j.hjb.2017.08.004
Herwin, H., Kosman, R., & Siami, I. (2013). Produksi Sediaan Kombucha Dari Daun Permot (Passiflora foetida L) Secara Fermentasi. As-Syifaa Jurnal Farmasi, 5(1), 20-27.
Ihedioha, J. I., Ugwuja, J. I., Noel-Uneke, O. A., Udeani, I. J., & Daniel-Igwe, G. (2012). Reference values for the haematology profile of conventional grade outbred.
Karinja, M., Pillai, G., Schlienger, R., Tanner, M., & Ogutu, B. (2019). Care-seeking dynamics among patients with diabetes mellitus and hypertension in selected rural settings in kenya. International Journal of Environmental Research and Public Health, 16(11), 1–15. https://doi.org/10.3390/ijerph16112016
Khaerati, K., Ihwan, I., & Maya, M. S. (2015). Efektivitas Antidiabetes Ekstrak Daun Rambusa (Passiflora Foetida L.) Pada Mencit (Mus Musculus) Dengan Induksi Glukosa. Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)(e-Journal), 1(2), 99-104. https://doi.org/10.22487/j24428744.2015.v1.i2.6240
Lunyera, J., Wang, D., Maro, V., Karia, F., Boyd, D., Omolo, J., Patel, U. D., & Stanifer, J. W. (2016). Traditional medicine practices among community members with diabetes mellitus in Northern Tanzania: An ethnomedical survey. BMC Complementary and Alternative Medicine, 16(1). https://doi.org/10.1186/s12906-016-1262-2
Mahan, V. L. (2014). Clinical trial phases. International Journal of Clinical Medicine, 5(21), 1374-1383.
Mulia, D. S., Mulyani, E., Rizki, M. I., & Pratama, M. R. F. (2019). Rambusa (Passiflora foetida L.) vs. Free Radicals: In Vitro Study With DPPH Method. Jurnal Pharmascience, 6(2), 1-7.
Mulyani, E. (2019). Studi In Vitro: Efek Anti Kolesterol Ekstrak Daun Rambusa (Passiflora foetida L): In Vitro Study: Anti-Cholesterol Effect of Rambusa Leaf Extract (Passiflora foetida L). Jurnal Surya Medika (JSM), 4(2), 60-65.
Nguma. (2010). Health Seeking and Health Related Behaviour for Type 2 Diabetes Mellitus among Adults in an Urban Community in Tanzania.
Nurdjanah, S., Sudoyo, A. W., Setiyohadi, B., Alwi, I., Simadibrata, K. M., & Setiati, S. (2007). Buku ajar ilmu penyakit dalam. Edisi ke, 6.
Oktarlina, R. Z., & Gumantara, M. P. B. (2017). Perbandingan monoterapi dan kombinasi terapi sulfonilurea-metformin terhadap pasien diabetes melitus tipe 2. Medical Journal of Lampung University [MAJORITY], 6(1).
Rahmawati, O. N. (2011). Pengaruh Penggunaan Tipe Basis Salep Hidrokarbon Dan Mudah Dicuci Air Dalam Formulasi Sediaan Salep Fraksi Heksan Herba Pegagan (Centella asiatica (L.) Urban) Terhadap Sifat Fisik Dan Kontrol Kualitasnya. Skripsi Universitas Negeri Malang, 39(1), 1–15. http://dx.doi.org/10.1016/j.biochi.2015.03.025%0Ahttp://dx.doi.org/10.1038/nature10402%0Ahttp://dx.doi.org/10.1038/nature21059%0Ahttp://journal.stainkudus.ac.id/index.php/equilibrium/article/view/1268/1127%0Ahttp://dx.doi.org/10.1038/nrmicro2577%0Ahttp://
Pitoyo, A. J., & Triwahyudi, H. (2018). Dinamika Perkembangan Etnis di Indonesia dalam Konteks Persatuan Negara. Populasi, 25(1), 64. https://doi.org/10.22146/jp.32416
Prayitno, B., & Mukti, B. H. (2017). Kajian Potensi Flora Kalimantan sebagai Bagian dari Kekayaan Daerah.
Qamariah, N., Handayani, R., & Novaryatiin, S. (2018). Kajian Empiris dan Etnofarmakologi Tumbuhan Hutan Berkhasiat Obat asal Desa Tumbang Rungan Kelurahan Pahandut Kota Palangkaraya Kalimantan Tengah: Empirical and Ethnopharmacological Study of Efficacious Medicinal Forest Plants from Tumbang Rungan Village, Pahandut Regency, Palangkaraya City, Central Kalimantan. Anterior Jurnal, 18(1), 98-106.
Saha, S., & Pal, D. (2021). Elicitor Signal Transduction Leading to the Production of Plant Secondary Metabolites. In Advanced Structured Materials (Vol. 140, Issue January). https://doi.org/10.1007/978-3-030-54027-2_1
Saleh, E. (2004). Teknologi pengolahan susu dan hasil ikutan ternak. Medan: Universitas Sumatera Utara.
Siriwardhene, M. A., Abeysekera, A. M., Chandrika, U. G., & Goonetilleke, A. K. E. (2013). Antihyperglycemic effect and phytochemical screening of aqueous extract of Passiflora foetida (Linn.) on normal Wistar rat model. African Journal of Pharmacy and Pharmacology, 7(45), 2892-2894.
Soelistijo, S. A., Novida, H., Rudijanto, A., Soewondo, P., Suastika, K., Manaf, A., ... & Zufry, H. (2015). Konsensus pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia 2015. Jakarta: PB Perkeni, 1-93.
Susanti, E., Shobur, S., & Retno, A. (2021). Manajemen Nutrisi Pasien Diabetes Melitus Tipe II Dengan Masalah Defisit Nutrisi: Studi Kasus. JKM : Jurnal Keperawatan Merdeka, 1(2), 240–245. https://doi.org/10.36086/jkm.v1i2.1007
Thorat, S. B., Banarjee, S. K., Gaikwad, D. D., Jadhav, S. L., & Thorat, R. M. (2010). Clinical trial: a review. International Journal of pharmaceutical sciences Review and Research, 1(2), 101-106.
World Health Organization. (2013). WHO traditional medicine strategy: 2014-2023. World Health Organization.
Zhao, X., Wang, W., Wang, J., Yang, J., & Xu, G. (2006). Urinary profiling investigation of metabolites with cis‐diol structure from cancer patients based on UPLC‐MS and HPLC‐MS as well as multivariate statistical analysis. Journal of separation science, 29(16), 2444-2451.
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