The Effect of Nutritional Interventions to Improve the Nutritional Status of Cancer Patients Undergoing Chemotherapy

  • Rita Sri Wahyuningsih Faculty of Nursing, Universitas Indonesia
  • Allenidekania Allenidekania Faculty of Nursing, Universitas Indonesia
Keywords: cancer patients, chemotherapy patients, nutritional intervention, nutritional status

Abstract

Cancer is a catabolic inflammatory disease that causes patients to experience frequent weight loss, or even cachexia in severe cases. Malnutrition in cancer patients impairs quality of life and therapeutic response, further leading to a poor prognosis. This study aims to determine various types of nutritional interventions that can improve the nutritional status of cancer patients undergoing chemotherapy. The research method used is a systematic review through electronic databases and websites, namely PubMed, Scopus, ProQuest, and MedLine. The keywords used for the search were "Nutrition Intervention" AND "Nutritional Status" AND "Cancer patients" OR "Chemotherapy patient". The search for supporting articles was limited to the years 2015-2023, resulting in the identification of 953 articles. After identification, screening, and extraction according to the inclusion and exclusion criteria, 12 articles were included. The research results showed that from 12 research articles, it was found that providing nutritional interventions could be in the form of oral nutritional supplements, omega 3 supplements, as well as other supplements such as propolis, broccoli supplements, and additional parenteral nutrition at home. Providing this nutritional intervention can improve the nutritional status of cancer patients undergoing chemotherapy.

References

Abd Allah et al. (2020). Nutritional status and its contributing factors among older adults with cancer receiving chemotherapy. Clinical Nursing Research 2020, Vol. 29(8) 650 –658. https://doi.org/10.1177/1054773820947953

Akita et al. (2019). The utility of nutritional supportive care with an eicosapentaenoic acid (EPA)-enriched nutrition agent during pre-operative chemoradiotherapy for pancreatic cancer: Prospective randomized control study. Clinical Nutrition ESPEN. 33 (2019) 148e153. https://doi.org/10.1016/j.clnesp.2019.06.003

Alsaleh, K, Almomen, F.A., Altaweel, A., Barasain, O., Alqublan, A., Binsalamah, A., et al. (2021). Malnutrition in cancer patients receiving chemotherapy in a single oncology center. Journal of Nature and Science of Medicine 2021;4:170-4.

Cintoni et al. (2023). Nutritional interventions during chemotherapy for pancreatic cancer: a systematic review of prospective studies. Nutrients 2023, 15(3), 727; https://doi.org/10.3390/nu15030727

de Souza, A.P.S.; da Silva, L.C.; Fayh, A.P.T. (2021). Nutritional intervention contributes to the improvement of symptoms related to quality of life in breast cancer patients undergoing neoadjuvant chemotherapy: a randomized clinical trial. Nutrients 2021, 13, 589. https://doi.org/10.3390/nu13020589

Dewi, N.M.A.P, Nurhesti, P.O.Y, Damayanti, M.R. (2020). Hubungan antara frekuensi kemoterapi dan status nutrisi pasien kanker yang menjalani kemoterapi di ruang sanjiwani rsup sanglah denpasar. Community of Publishing In Nursing (COPING), p-ISSN 2303-1298, e-ISSN 2715-1980

Gui L, Cheng M, Zheng M, Ning C and Huo Q. (2023). Effects of omega-3 fatty acid supplementation on nutritional status and inflammatory response in patients with stage II-III NSCLC undergoing postoperative chemotherapy: a double-blind randomized controlled trial. Frontiers in Nutrition. 10:1266584. doi: 10.3389/fnut.2023.1266584

Haidari et al. (2020). Randomized study of the effect of vitamin D and omega-3 fatty acids supplementation as adjuvant chemotherapy on inflammation and nutritional status in colorectal cancer patients. Journal Of Dietary Supplements 2020, VOL. 17, NO. 4, 384–400 https://doi.org/10.1080/19390211.2019.1600096

Handayani, Nur. (2022). Kanker dan Serba-Serbinya (Hari Kanker Sedunia 2022). Jogjakarta: RS Paru Respira

Jiang W, Ding H, Li W, Ling Y, Hu C & Shen C. (2018). Benefits of oral nutritional supplements in patients with locally advanced nasopharyngeal cancer during concurrent chemoradiotherapy: an exploratory prospective randomized trial, Nutrition, and Cancer, 70:8, 1299-1307, DOI: 10.1080/01635581.2018.1557222

Kim, D.H. (2019). Nutritional issues in patients with cancer. Intestinal Research 2019;17(4):455-462. https://doi.org/10.5217/ir.2019.00076

Kim et al. (2019). The effect of nutrition intervention with oral nutritional supplements on pancreatic and bile duct cancer patients undergoing chemotherapy. Nutrients. 2019, 11, 1145; doi:10.3390/nu11051145

Lewandowska, A.; Religioni, U.; Czerw, A.; Deptała, A.; Karakiewicz, B.; Partyka, O.; Pajewska, M.; Sygit, K.; Cipora, E.; Kmiec´, K.; et al. Nutritional treatment of patients with colorectal cancer. International Journal of Environmental Research and Public Health 2022, 19, 6881. https:// doi.org/10.3390/ijerph19116881

Lima, M.T.M, Maruyama, T.C, Cust´odio, I.D.D., Marinho, E.C, Ferreira, I.B., Crispim, C.A., Paiva, C.E and Maia, Y.C.P. (2020). The impact of a higher eating frequency on the diet quality and nutritional status of women with breast cancer undergoing chemotherapy. British Journal of Nutrition (2020), 123, 410–418 doi:10.1017/S0007114519002952

Lin, Jin-Xiang BSa; Chen, Xiang-Wei BNa; Chen, Zhan-Hong MDa; Huang, Xiu-Yan BNa; Yang, Jin-Jie BNa; Xing, Yan-Fang MDb; Yin, Liang-Hong MDc; Li, Xing MDa,*; Wu, Xiang-Yuan MDa. A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy: A clinical trial. Medicine 96(26):p e7373, June 2017. | DOI: 10.1097/MD.0000000000007373

Lozanovski et al, Jerman (2019). Broccoli sprout supplementation in patients with advanced pancreatic cancer is difficult despite positive effects—results from the POUDER pilot study. Investigational New Drugs. (2020) 38:776–784. https://doi.org/10.1007/s10637-019-00826-z

Ma, CJ., Huang, CW., Yeh, YS. et al. Supplemental home parenteral nutrition improved nutrition status with comparable quality of life in malnourished unresectable/metastatic gastric cancer receiving salvage chemotherapy. Support Care Cancer 29, 1977–1988 (2021). https://doi.org/10.1007/s00520-020-05687-4

Miao, J., Wang, L., Ong, E.H.W., et al. (2023). Effects of induction chemotherapy on nutrition status in locally advanced nasopharyngeal carcinoma: a multicentre prospective study. Journal of Cachexia, Sarcopenia and Muscle 2023; 14: 815–825. DOI: 10.1002/jcsm.13196

Muhamed, A.N et al. (2022). Nutritional status and its determinants among adult cancer patients undergoing chemotherapy treatment at hawassa university comprehensive specialized hospital, hawassa, southern Ethiopia. Hindawi Journal of Nutrition and Metabolism Volume 2022, Article ID 8740272, 8 pages https://doi.org/10.1155/2022/8740272

Plyta, M., Patel, P, et al. (2020). Nutritional status and quality of life in hospitalised cancer patients who develop intestinal failure and require parenteral nutrition: an observational study. Nutrients. 2020, 12, 2357; doi:10.3390/nu12082357

Qin et al. (2021). The effect of nutrition intervention with oral nutritional supplements on ovarian cancer patients undergoing chemotherapy. Frontiers in Nutrition. doi: 10.3389/fnut.2021.685967

Ravasco, Paula. (2019). Nutrition in cancer patients. Journal of Clinical Medicine, 2019, 8, 1211; doi:10.3390/jcm8081211

Sakuramoto, A.; Hasegawa, Y.; Sugahara, K.; Horii, N.; Saito, S.; Nakao, Y.; Nanto, T.; Ono, T.; Domen, K.; Kishimoto, H. (2021) Change in nutritional status and dysphagia after resection of head and neck cancer. Nutrients 2021, 13, 2438. https://doi.org/10.3390/nu13072438

Santosa, A., Mulatsih, S., Susetyowati. (2019). Identifikasi risiko malnutrisi dan evaluasi status nutrisi pasien kanker anak dengan pengobatan kemoterapi. Jurnal Gizi Klinik Indonesia Vol 15 No 4 - April 2019 (137-145)

Sugiyama, K. et al. (2023). The impact of nutritional support on survival outcomes in patients with advanced gastric adenocarcinoma treated with chemotherapy. Nutrition and Cancer 2023, VoL. 75, No. 3, 867–875. DOI: 10.1080/01635581.2022.2162090.

Published
2024-05-25
How to Cite
Wahyuningsih, R. S., & Allenidekania, A. (2024). The Effect of Nutritional Interventions to Improve the Nutritional Status of Cancer Patients Undergoing Chemotherapy. Indonesian Journal of Global Health Research, 6(4), 2077-2086. https://doi.org/10.37287/ijghr.v6i4.3205