Ankle Joint Chronic Osteomyelitis: A Case Report and Updated Insights

Keywords: comorbidity, degenerative disease, infectious disease, osteomylitis, type 2 diabetes mellitus

Abstract

Osteomyelitis is an infectious disease of the musculoskeletal system that can cause inflammation of the bones and joints caused by infectious agents. To date, there has been an increase in Osteomyelitis cases especially in individuals with comorbidities. The aimed of this study was to explore the frequent cases of chronic ankle joint osteomyelitis experienced by the public and provide new insights into the future treatment of this disease. In this study, we report the case of a patient with type 2 diabetes mellitus who developed osteomyelitis due to a wound caused by a scratch on a prickly pandanus leaf mat. A 58-year-old man presented to the emergency room with complaints of sores and pain, accompanied by swelling of the right foot. The wound on the leg oozed pus had an odor, and the patient had difficulty walking and fever for two weeks. Her hemoglobin level was 10 mg/dl, her leukocyte count was 20,040/µL, her current blood sugar level was 323 mg/dL, her 2-hour PP blood sugar level was 415 mg/dL, and her HbA1c level was 12. On foot examination, a CRT of < 2 s was found, and the degree of dorsal pedic artery pulsation was weak. An opaque area was observed in the ankle joint of the right foot, accompanied by a distal 1/3 epi-metaphyseal fracture of the right fibula bone with swelling, a distal 1/3 epiphyseal deformity of the right tibia bone, and a calcaneal spur on X-ray. Trauma and systemic risk factors such as diabetes mellitus were found in the patient, increasing the risk of worsening chronic osteomyelitis. The principles of osteomyelitis management include optimizing the patient's general condition; performing pharmacological debridement, reconstruction, and stabilization; and completing rehabilitation. Recent insights highlight the importance of a multidisciplinary approach, advanced diagnostic tools, antibiotic stewardship, novel therapies, and patient-centered care to improve outcomes for individuals affected by this challenging condition in the future.

Author Biographies

Fanny Eprilia Tika, General practitioner in Puskesmas Sangkalan

General practitioner in Puskesmas Sangkalan

Ismail Muhammad, Teungku Pekan Hospital

Department of Surgery in Teungku Pekan Hospital

Dwinka Syafira Eljatin, Faculty of Medicine and Health, Institut Teknologi Sepuluh Nopember & Indonesian Society of Epidemiologists

Department of Medical Education, Faculty of Medicine and Health, Institut Teknologi Sepuluh Nopember

I Made Dwi Mertha Adnyana, Faculty of Information, Technology and Science, Universitas Hindu Indonesia & Indonesian Society of Epidemiologists

Department of Biology, Faculty of Information, Technology and Science, Universitas Hindu Indonesia

References

Adnyana, I. M. D. M. (2022). Prinsip Epidemiologi. In A. I. Asir (Ed.), Epidemiologi Penyakit Menular (1st ed., pp. 19–40). CV Media Sains Indonesia.

Adnyana, I. M. D. M., Utomo, B., Eljatin, D. S., & Sudaryati, N. L. G. (2023). One Health approach and zoonotic diseases in Indonesia: Urgency of implementation and challenges. Narra J, 3(3), e257. https://doi.org/10.52225/narra.v3i3.257

Alkhalfan, Y., Lewis, T. L., Kavarthapu, V., & Hester, T. (2024). Investigation and management of diabetic foot osteomyelitis: An update for the foot and ankle orthopaedic surgeon. Journal of Clinical Orthopaedics and Trauma, 48, 102330. https://doi.org/10.1016/j.jcot.2023.102330

Allen, H., Barnthouse, N. C., & Brian Y. Chan. (2023). Periosteal pathologic conditions: imaging findings and pathophysiology. RadioGraphics, 43(2), e220120. https://doi.org/10.1148/rg.220120

Apley, A. G., & Solomon, L. (2019). System of Orthopaedic and Fractures (9th ed.). Arnold an Hachette UK Company.

Ariastuti, I., Adnyana, I. M. D. M., Wahyudi, I. W., Ari Sundari, N. L. P., Winda Savitri, I. A. G., Dewi, G. A. P. W. P., & Nuartha, P. K. A. R. (2023). Exposure to radioactive elements in increasing acute radiation syndrome (ARS): A narrative review. Jurnal Widya Biologi, 14(2), 108–126. https://doi.org/10.32795/widyabiologi.v14i02.5029

Arnold, J. C., & Bradley, J. S. (2015). Osteoarticular infections in children. Infectious Disease Clinics of North America, 29(3), 557–574. https://doi.org/10.1016/j.idc.2015.05.012

Balasubramanian, S., Devarajan, H. R., Raparthi, M., Dodda, S. B., Maruthi, S., & Adnyana, I. M. D. M. (2023). Ethical Considerations in AI-assisted decision making for end-of-life care in healthcare. Power System Technology, 47(4), 167–184. https://doi.org/10.52783/pst.168

Berendt, A. R., Peters, E. J. G., Bakker, K., Embil, J. M., Eneroth, M., Hinchliffe, R. J., Jeffcoate, W. J., Lipsky, B. A., Senneville, E., Teh, J., & Valk, G. D. (2008). Diabetic foot osteomyelitis: a progress report on diagnosis and a systematic review of treatment. Diabetes/Metabolism Research and Reviews, 24(S1), S145–S161. https://doi.org/10.1002/dmrr.836

Bermejo Olano, M. del M., Campelo Gutierrez, C., Hervas Gómez, R., Alfayate García, J. M., Sánchez Ríos, J. P., & Moreno Núñez, L. (2024). Risk factors associated with osteomyelitis due to Corynebacterium striatum in patients with diabetic foot. Medicina Clínica (English Edition), 162(1), 15–18. https://doi.org/10.1016/j.medcle.2023.09.011

Bor, N., Dujovny, E., Rinat, B., Rozen, N., & Rubin, G. (2022). Treatment of chronic osteomyelitis with antibiotic-impregnated polymethyl methacrylate (PMMA) – the Cierny approach: is the second stage necessary? BMC Musculoskeletal Disorders, 23(1), 38. https://doi.org/10.1186/s12891-021-04979-y

Caravaggio, F., Antonelli, M., & Depalmi, F. (2021). Regenerative medicine: potential applications for foot and ankle disorders. Lo Scalpello - Otodi Educational, 35(2), 117–128. https://doi.org/10.36149/0390-5276-208

Carro, G. V., de Jesus, F. M., & Ricci, A. (2023). Diabetic Foot Osteomyelitis: Is it all the Same? The International Journal of Lower Extremity Wounds, 153473462311606. https://doi.org/10.1177/15347346231160614

Cheng, X., Su, Y., & Huang, M. (2023). Osteomyelitis: case 5. In Imaging of Bone Tumors in Wrist, Hand, Ankle and Foot (pp. 119–121). Springer Nature Singapore. https://doi.org/10.1007/978-981-99-6407-9_30

Colston, J., & Atkins, B. (2018). Bone and joint infection. Clinical Medicine, 18(2), 150–154. https://doi.org/10.7861/clinmedicine.18-2-150

Coonahan, E., Shahrvini, B., Birabaharan, M., Farid, N., & Cowell, A. (2024). A case of Staphylococcus epidermidis osteomyelitis in the absence of spine hardware. IDCases, 35, e01928. https://doi.org/10.1016/j.idcr.2024.e01928

Desimple, J., Posadzy, M., & Vanhoenacker, F. (2017). The Many Faces of Osteomyelitis : A Pictoral Review. Ournal of the Belgian Society of Radiology, 101(1), 1–10. https://doi.org/10.5334/jbr-btr:1300

Ferguson, I. T., & Carpenter, C. R. (2023). Osteomyelitis. In Evidence‐Based Emergency Care (pp. 388–400). John Wiley & Sons Ltd. https://doi.org/10.1002/9781119616870.ch33

Foti, G., Longo, C., Sorgato, C., Oliboni, E. S., Mazzi, C., Motta, L., Bertoli, G., & Marocco, S. (2023). Osteomyelitis of the Lower Limb: Diagnostic Accuracy of Dual-Energy CT versus MRI. Diagnostics, 13(4), 703. https://doi.org/10.3390/diagnostics13040703

Hatzenbuehler, J., & Pulling, T. J. (2011). Diagnosis and management of osteomyelitis. Am Fam Physician, 84, 1027–1033. https://www.aafp.org/pubs/afp/issues/2011/1101/p1027.html

Hogan, A., Heppert, V. G., & Suda, A. J. (2013). Osteomyelitis. Archives of Orthopaedic and Trauma Surgery, 133(9), 1183–1196. https://doi.org/10.1007/s00402-013-1785-7

Hosseini, M., Allami, M., Soroush, M., Babaha, F., Minooeefar, J., & Rahimpoor, D. (2018). Chronic traumatic ankle and foot osteomyelitis: a nationwide case-control study. Military Medical Research, 5(1), 15. https://doi.org/10.1186/s40779-018-0163-8

Hutagalung, M., Eljatin, D., Sarie, V., Sianturi, G., & Santika, G. (2019). Diabetic foot infection (infeksi kaki diabetik): Diagnosis dan tatalaksana. Jurnal Cermin Dunia Kedokteran, 46(6), 414–418. https://doi.org/10.55175/cdk.v46i6.434

Irianto KA, Gema A, S. W. (2019). Acute hematogenous osteomyelitis in children: a case series. Paediatr Indones, 59(4), 222–8. https://doi.org/10.14238/pi59.4.2019.222-8

Juliasih, N. K. A., & Adnyana, I. M. D. M. (2023). Utilization of Pteridophyta species in Cyathea Park, Bali, as traditional medicine agents: A field study and meta-synthesis review. Notulae Scientia Biologicae, 15(2), 11522. https://doi.org/10.55779/nsb15211522

Kliushin, N. M., Burnashov, S. I., Mekki, W. A., Leonchuk, D. S., & Sudnitsyn, A. S. (2022). Treatment of postoperative tibial chronic osteomyelitis using bone transport techniques; an observational study. Journal of Clinical Orthopaedics and Trauma, 24, 101652. https://doi.org/10.1016/j.jcot.2021.101652

Kremers, H. M., Nwojo, M. E., Ransom, J. E., Wood-Wentz, C. M., Melton, L. J., & Huddleston, P. M. (2015). Trends in the epidemiology of osteomyelitis. Journal of Bone and Joint Surgery, 97(10), 837–845. https://doi.org/10.2106/JBJS.N.01350

Lázaro-Martínez, J. L., Tardáguila-García, A., & García-Klepzig, J. L. (2017). Diagnostic and therapeutic update on diabetic foot osteomyelitis. Endocrinología, Diabetes y Nutrición (English Ed.), 64(2), 100–108. https://doi.org/10.1016/j.endien.2017.03.003

Lee, Y. J., Sadigh, S., Mankad, K., Kapse, N., & Rajeswaran, G. (2016). The imaging of osteomyelitis. Quantitative Imaging in Medicine and Surgery, 6(2), 184–198. https://doi.org/10.21037/qims.2016.04.01

Liu, Z., Ren, Y., Meng, L., Li, L., Beatson, R., Deng, J., Zhang, T., Liu, J., & Han, X. (2021). Epigenetic signaling of cancer stem cells during inflammation. Frontiers in Cell and Developmental Biology, 9, 772211. https://doi.org/10.3389/fcell.2021.772211

Llewellyn, A., Kraft, J., Holton, C., Harden, M., & Simmonds, M. (2020). Imaging for detection of osteomyelitis in people with diabetic foot ulcers: A systematic review and meta-analysis. European Journal of Radiology, 131, 109215. https://doi.org/10.1016/j.ejrad.2020.109215

Malone, M., Bowling, F. L., Gannass, A., Jude, E. B., & Boulton, A. J. M. (2013). Deep wound cultures correlate well with bone biopsy culture in diabetic foot osteomyelitis. Diabetes/Metabolism Research and Reviews, 29(7), 546–550. https://doi.org/10.1002/dmrr.2425

Mifsud, M., & McNally, Martin. A. (2023). Paediatric bone and joint infections: a guide from diagnosis to management. Orthopaedics and Trauma, 37(6), 344–352. https://doi.org/10.1016/j.mporth.2023.09.004

Peng, P., Dong, Z.-G., Liu, L., Wei, J.-W., Luo, Z., & Cao, S. (2023). An effective technique for managing the calcaneus osteomyelitis combined with soft-tissue defect. The International Journal of Lower Extremity Wounds, 22(2), 393–400. https://doi.org/10.1177/15347346211016696

Qin, C.-H., Zhou, C.-H., Ren, Y., Cheng, G.-Y., Zhang, H.-A., Fang, J., & Tao, R. (2020). Extensive eggshell-like debridement technique plus antibiotic-loaded calcium sulphate for one-stage treatment of chronic calcaneal osteomyelitis. Foot and Ankle Surgery, 26(6), 644–649. https://doi.org/10.1016/j.fas.2019.08.008

Rafferty, B. A., & Thakrar, P. (2024). Chronic recurrent multifocal osteomyelitis. Medical Clinics of North America, 108(1), 227–239. https://doi.org/10.1016/j.mcna.2023.05.022

Sambri, A., Spinnato, P., Tedeschi, S., Zamparini, E., Fiore, M., Zucchini, R., Giannini, C., Caldari, E., Crombé, A., Viale, P., & De Paolis, M. (2021). Bone and joint infections: the role of imaging in tailoring diagnosis to improve patients’ care. Journal of Personalized Medicine, 11(12), 1317. https://doi.org/10.3390/jpm11121317

Sananta, P., Huwae, T. E. C. J., Ronadi, D., & Dhakka Siahaan, L. (2021). The antibiotic use in osteomyelitis infection: A systematic review. Open Access Macedonian Journal of Medical Sciences, 9(F), 720–723. https://doi.org/10.3889/oamjms.2021.7680

Senneville, E., & Robineau, O. (2021). Diabetic foot osteomyelitis. In Bone and Joint Infections (1st ed., pp. 337–351). John Wiley & Sons Ltd. https://doi.org/10.1002/9781119720676.ch21

Sitinjak, A. V. D., Riza, A., & Kurnia, D. (2022). Gambaran kejadian kasus osteomielitis di bagian bedah ortopedi RSUP Dr. M. Djamil Kota Padang tahun 2018-2020. Jurnal Ilmu Kesehatan Indonesia, 3(1), 57–66. https://doi.org/10.25077/jikesi.v3i1.728

Soares, F. O., Rosado, I. R., Sousa, M. V. C., Dumont, C. F., Bittar, J. F. F., Martin, I., Beletti, M. E., Melo, R. T., & Alves, E. G. L. (2024). Osteomyelitis by Microsporum canis and Staphylococcus spp. in cat (Felis catus) – case report. BMC Veterinary Research, 20(1), 58. https://doi.org/10.1186/s12917-024-03904-4

Solomon, L., Warwick, D., & Nayagam, S. (2010). Apley’s System of Orthopaedics and Fractures (1st ed.). CRC Press. https://doi.org/10.1201/b13422

St. Jeor, J. D., Thomas, K. B., Thacker, P. G., & Hull, N. C. (2020). Multifocal subacute osteomyelitis in adjacent bones in the ankle without septic joint. Radiology Case Reports, 15(10), 1927–1930. https://doi.org/10.1016/j.radcr.2020.07.073

Subramanyam, K. N., Mundargi, A. V., Prabhu, M. V., Gopakumar, K. U., Gowda, D. S. A., & Reddy, D. R. (2023). Surgical management of chronic osteomyelitis: Organisms, recurrence and treatment outcome. Chinese Journal of Traumatology, 26(4), 228–235. https://doi.org/10.1016/j.cjtee.2023.01.003

Sutriyawan, A., Jayanti, K. D., Handayani, D., Arfan, I., Adnyana, I. M. D. M., Muna, K. U. N. El, Purnama, R. M. I., Setiawan, D. I., Handayani, D., Nuraeni, T., Fauziah, D. A., Susanti, A., & Rachman, I. (2023). Surveilans Kesehatan Masyarakat (H. Akbar, Ed.; 1st ed.). CV. Media Sains Indonesia.

Wassif, R. K., Elkayal, M., Shamma, R. N., & Elkheshen, S. A. (2021). Recent advances in the local antibiotics delivery systems for management of osteomyelitis. Drug Delivery, 28(1), 2392–2414. https://doi.org/10.1080/10717544.2021.1998246

Wijendra, A., Ramsden, A., & Martin McNally. (2023). A natural history of untreated chronic osteomyelitis of the tibia over 20 years, with evolving squamous cell carcinoma: a case report. JBJI, 8(4), 183–188. https://doi.org/10.5194/jbji-8-183-2023

Woo, I., Cho, S. J., & Park, C. H. (2023). State-of-the-art update for diagnosing diabetic foot osteomyelitis: a narrative review. Journal of Yeungnam Medical Science, 40(4), 321–327. https://doi.org/10.12701/jyms.2023.00976

Xin, W., Gao, Y., & Yue, B. (2022). Recent advances in multifunctional hydrogels for the treatment of osteomyelitis. Frontiers in Bioengineering and Biotechnology, 10, 865250. https://doi.org/10.3389/fbioe.2022.865250

Yeo, A.; Ramachandran, M. (2014). Acute haematogenous osteomyelitis in children. BMJ, 348(g66). https://doi.org/10.1136/bmj.g66

Yılmaz, E., & İncesoy, M. A. (2024). Adult-onset chronic recurrent multifocal osteomyelitis: a case report. Skeletal Radiology, 53(2), 395–400. https://doi.org/10.1007/s00256-023-04413-5

Zaki, I., & Morrison, W. B. (2023). Osteomyelitis and Septic Arthritis of the Foot and Ankle. Foot and Ankle Clinics, 28(3), 589–602. https://doi.org/10.1016/j.fcl.2023.05.009

Zeng, M., Xu, Z., Song, Z.-Q., Li, J.-X., Tang, Z.-W., Xiao, S., & Wen, J. (2023). Diagnosis and treatment of chronic osteomyelitis based on nanomaterials. World Journal of Orthopedics, 14(2), 42–54. https://doi.org/10.5312/wjo.v14.i2.42

Ziegeler, K., Eshed, I., Diekhoff, T., & Hermann, K. G. (2020). Imaging of Joints and Bones in Autoinflammation. Journal of Clinical Medicine, 9(12), 4074. https://doi.org/10.3390/jcm9124074

Published
2024-03-07
How to Cite
Tika, F. E., Muhammad, I., Eljatin, D. S., & Adnyana, I. M. D. M. (2024). Ankle Joint Chronic Osteomyelitis: A Case Report and Updated Insights. Indonesian Journal of Global Health Research, 6(2), 583-598. https://doi.org/10.37287/ijghr.v6i2.2902