Efficacy and Safety of Curcuma Longa Extract in Patients with Osteoarthritis: A Literature Review
Abstract
Osteoarthritis (OA) is a chronic degenerative inflammatory disease that attacks the joints, especially the knee joints, in millions of people throughout the world. The main symptom of this disease is joint pain. Many studies have shown that components of Curcuma longa have beneficial effects in the pain management of OA patients. Objective to determine the efficacy and side effects of Curcuma longa in managing pain in patients suffering from osteoarthritis. Literature was created through various reference sources such as Pubmed, ScienceDirect, Google Scholar, and Epistemonikos which were screened against several inclusion criteria from 2013 - 2023. From the 277 articles obtained, 2 articles were obtained. Curcuma longa has been proven to significantly reduce pain scores according to VAS and WOMAC criteria. Apart from that, its effectiveness is not much different compared to non-steroidal anti-inflammatory drugs (NSAIDs). However, fewer side effects were reported in the Curcuma longa group. Curcuma longa can be used as a therapeutic option for mild to moderate osteoarthritis, especially in patients who cannot tolerate the side effects of NSAIDs.
References
Akuri, M. C., Barbalho, S. M., Val, R. M., & Guiguer, E. L. (2017). Reflections about Osteoarthritis and Curcuma longa. 8–12. https://doi.org/10.4103/phrev.phrev
Akuri, M. C., Barbalho, S. M., Val, R. M., Guiguer, E. L., Hsiao, A., Lien, Y., Tzeng, I., Liu, C., Chou, S., Henrique, L., Martines, A., Marconato, G. G., Fracaro, G. G., Laurindo, L. F., Cressoni, A., Rubira, C. J., Dias, J. A., Sandra, M., Dai, W., … Akamatsu, S. (2021). Therapeutic Effects of Curcumin on Osteoarthritis and Its Protection of Chondrocytes Through the Wnt/Β-Catenin Signaling Pathway. Trials, 22(1), 1–12. https://doi.org/10.7326/M20-0990
Cas, M. D., & Ghidoni, R. (2019). Dietary curcumin: Correlation between bioavailability and health potential. Nutrients, 11(9), 1–14. https://doi.org/10.3390/nu11092147
Dai, W., Yan, W., Chen, J., Hu, X., & Ao, Y. (2021). Effectiveness of Curcuma longa extract versus placebo for the treatment of knee osteoarthritis : A systematic review and meta-analysis of randomized controlled trials. January, 1–15. https://doi.org/10.1002/ptr.7204
Daily, J. W., Yang, M., & Park, S. (2016). Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. Journal of Medicinal Food, 19(8), 717–729. https://doi.org/10.1089/jmf.2016.3705
Ebrahimzadeh, M. H., Makhmalbaf, H., Birjandinejad, A., Keshtan, F. G., Hoseini, H. A., & Mazloumi, S. M. (2014). The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) in Persian Speaking Patients with Knee Osteoarthritis. 57(1), 57–62.
Feng, J., Li, Z., Tian, L., Mu, P., Hu, Y., Xiong, F., & Ma, X. (2022). Efficacy and safety of curcuminoids alone in alleviating pain and dysfunction for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials. BMC Complementary Medicine and Therapies, 22(1), 1–22. https://doi.org/10.1186/s12906-022-03740-9
Gupte, P. A., Giramkar, S. A., Harke, S. M., Kulkarni, S. K., Deshmukh, A. P., Hingorani, L. L., Mahajan, M. P., & Bhalerao, S. S. (2019). Evaluation of the efficacy and safety of capsule longvida® optimized curcumin (solid lipid curcumin particles) in knee osteoarthritis: A pilot clinical study. Journal of Inflammation Research, 12, 145–152. https://doi.org/10.2147/JIR.S205390
Haroyan, A., Mukuchyan, V., Mkrtchyan, N., Minasyan, N., Gasparyan, S., Sargsyan, A., Narimanyan, M., & Hovhannisyan, A. (2018). Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: A comparative, randomized, double-blind, placebo-controlled study. BMC Complementary and Alternative Medicine, 18(1), 1–16. https://doi.org/10.1186/s12906-017-2062-z
Heger, M., van Golen, R. F., Broekgaarden, M., & Michel, M. C. (2014). The molecular basis for the pharmacokinetics and pharmacodynamics of curcumin and its metabolites in relation to cancers. Pharmacological Reviews, 66(1), 222–307. https://doi.org/10.1124/pr.110.004044
Henrique, L., Martines, A., Marconato, G. G., Fracaro, G. G., Laurindo, L. F., Cressoni, A., Rubira, C. J., Dias, J. A., & Sandra, M. (2022). The Effects of Curcuma Longa on the Osteoarthritis : A Systematic Review of Placebo-Controlled Clinical Studies. 1–17.
Henrotin, Y., Gharbi, M., Dierckxsens, Y., Priem, F., Marty, M., Seidel, L., Albert, A., Heuse, E., Bonnet, V., & Castermans, C. (2014). Decrease of a specific biomarker of collagen degradation in osteoarthritis, Coll2-1, by treatment with highly bioavailable curcumin during an exploratory clinical trial. BMC Complementary and Alternative Medicine, 14. https://doi.org/10.1186/1472-6882-14-159
Hsiao, A. F., Lien, Y. C., Tzeng, I. S., Liu, C. T., Chou, S. H., & Horng, Y. S. (2021). The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic review and meta-analysis. In Complementary Therapies in Medicine (Vol. 63, p. 102775). Elsevier Ltd. https://doi.org/10.1016/j.ctim.2021.102775
Jamadi, N., Adib-Hajbaghery, M., & Soleimani, A. (2019). The effect of Curcumin ointment on knee pain and quality of life in older adults with osteoarthritis. BMC Complementary Medicine and Therapies, 0, 1–10.
Liu, X., Machado, G. C., Eyles, J. P., Ravi, V., & Hunter, D. J. (2018). Dietary supplements for treating osteoarthritis: A systematic review and meta-Analysis. British Journal of Sports Medicine, 52(3), 167–175. https://doi.org/10.1136/bjsports-2016-097333
Lopresti, A. L., Smith, S. J., Jackson-michel, S., & Fairchild, T. (2022). An investigation into the effects of a curcumin extract (Curcugen®) on osteoarthritis pain of the knee: A randomised, double-blind, placebo-controlled study. Nutrients, 14(1). https://doi.org/10.3390/nu14010041
Madhu, K., Chanda, K., & Saji, M. J. (2013). Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial. Inflammopharmacology, 21(2), 129–136. https://doi.org/10.1007/s10787-012-0163-3
Mashhadi. (2021). A Systematic Review of the Clinical Use of Curcumin for the Treatment of Osteoarthritis.
Nakagawa, Y., Mukai, S., Yamada, S., Matsuoka, M., Tarumi, E., Hashimoto, T., Tamura, C., Imaizumi, A., Nishihira, J., & Nakamura, T. (2014). Short-term effects of highly-bioavailable curcumin for treating knee osteoarthritis: a randomized, double-blind, placebo-controlled prospective study. Journal of Orthopaedic Science, 19(6), 933–939. https://doi.org/10.1007/s00776-014-0633-0
Nakagawa, Y., Mukai, S., Yamada, S., Murata, S., Yabumoto, H., Maeda, T., & Akamatsu, S. (2020). The Efficacy and Safety of Highly-Bioavailable Curcumin for Treating Knee Osteoarthritis: A 6-Month Open-Labeled Prospective Study. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders, 13. https://doi.org/10.1177/1179544120948471
Panahi, Y., Alishiri, G. H., Parvin, S., & Sahebkar, A. (2016). Mitigation of Systemic Oxidative Stress by Curcuminoids in Osteoarthritis: Results of a Randomized Controlled Trial. Journal of Dietary Supplements, 13(2), 209–220. https://doi.org/10.3109/19390211.2015.1008611
Pinzon, R. T., & Wijaya, V. O. (2019). Curcuma longa and Boswellia serrata for Improving Functional Status in Osteoarthritis Patients: From Bench to Bedside Evidences. Asian Journal of Medical Sciences, 10(5), 1–5. https://doi.org/10.3126/ajms.v10i5.24918
Puente, R., Illnait, J., Mas, R., Carbajal, D., Mendoza, S., Fernández, J. C., Mesa, M., Gámez, R., & Reyes, P. (2014). Evaluation of the effect of D-002, a mixture of beeswax alcohols, on osteoarthritis symptoms. Korean Journal of Internal Medicine, 29(2), 191–202. https://doi.org/10.3904/kjim.2014.29.2.191
Sathiyanarayanan, S., Shankar, S., & Padmini, S. K. (2017). Usefulness of WOMAC index as a screening tool for knee osteoarthritis among patients attending a rural health care center in Tamil Nadu. 4(11), 4290–4295.
Shen, L., Liu, C. C., An, C. Y., & Ji, H. F. (2016). How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Scientific Reports, 6(March 2015), 1–10. https://doi.org/10.1038/srep20872
Shep, D., Khanwelkar, C., Gade, P., & Karad, S. (2019). Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: A randomized open-label parallel-arm study. Trials, 20(1). https://doi.org/10.1186/S13063-019-3327-2
Shep, D., Khanwelkar, C., Gade, P., Karad, S., & Zhang, Q. (2020). Efficacy and safety of combination of curcuminoid complex and diclofenac versus diclofenac in knee osteoarthritis: A randomized trial. Medicine (United States), 99(16), E19723. https://doi.org/10.1097/MD.0000000000019723
Shin, Y. A., Suk, M. H., Jang, H. S., & Choi, H. J. (2017). Short-term effects of Theracurmin dose and exercise type on pain, walking ability, and muscle function in patients with knee osteoarthritis. Journal of Exercise Rehabilitation, 13(6), 684–692. https://doi.org/10.12965/jer.1735064.532
Singhal, S., Hasan, N., Nirmal, K., Chawla, R., Chawla, S., Kalra, B. S., & Dhal, A. (2021). Bioavailable turmeric extract for knee osteoarthritis: a randomized, non-inferiority trial versus paracetamol. Trials, 22(1), 1–11. https://doi.org/10.1186/s13063-021-05053-7
Srivastava, S., Saksena, A. K., Khattri, S., Kumar, S., & Dagur, R. S. (2016). Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial. Inflammopharmacology, 24(6), 377–388. https://doi.org/10.1007/s10787-016-0289-9
Sterzi, S., Giordani, L., Morrone, M., Lena, E., Magrone, G., Scarpini, C., Milighetti, S., Pellicciari, L., Bravi, M., Panni, I., Ljoka, C., Bressi, F., & Foti, C. (2016). The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: A randomized, double-blind, placebo-controlled study. European Journal of Physical and Rehabilitation Medicine, 52(3), 321–330.
Veronese, N. (2020). Reply to: “bio-optimized Curcuma longa extract is efficient on knee osteoarthritis pain: A double-blind multicenter randomized placebo controlled three-arm study.” Arthritis Research and Therapy, 22(1), 1–11. https://doi.org/10.1186/s13075-020-2107-4
Wang, J., Ma, J., Gu, J. H., Wang, F. Y., Shang, X. S., Tao, H. R., & Wang, X. (2017). Regulation of type II collagen, matrix metalloproteinase-13 and cell proliferation by interleukin-1β is mediated by curcumin via inhibition of NF-κB signaling in rat chondrocytes. Molecular Medicine Reports, 16(2), 1837–1845. https://doi.org/10.3892/mmr.2017.6771
Wang, Z., Jones, G., Winzenberg, T., Cai, G., Laslett, L. L., Aitken, D., Hopper, I., Singh, A., Jones, R., Fripp, J., Ding, C., & Antony, B. (2020). Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Annals of Internal Medicine, 173(11), 861–869. https://doi.org/10.7326/M20-0990
Yuan, T., Cai, D., Hu, B., Zhu, Y., & Qin, J. (2022). Therapeutic Effects of Curcumin on Osteoarthritis and Its Protection of Chondrocytes Through the Wnt/Β-Catenin Signaling Pathway. Alternative Therapies in Health and Medicine, 28(5), 28–37.
Zeng, L., Yu, G., Hao, W., Yang, K., & Chen, H. (2021). The efficacy and safety of Curcuma longa extract and curcumin supplements on osteoarthritis: A systematic review and meta-analysis. Bioscience Reports, 41(6), 1–20. https://doi.org/10.1042/BSR20210817
Copyright (c) 2024 Indonesian Journal of Global Health Research
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
