The Correlation between TNF-α  Serum Level and Andropause with Quality of Life on Elderly

Trisna Yuliharti Tersinanda; RA Tuty Kuswardhani; Wimpie I Pangkahila

doi:10.37287/ijghr.v2i3.186

Trisna Yuliharti Tersinanda Universitas Udayana
RA Tuty Kuswardhani Universitas Udayana
Wimpie I Pangkahila Universitas Udayana

DOI: https://doi.org/10.37287/ijghr.v2i3.186

Keywords: andropause, elderly, quality of life, TNF-α serum

Abstract

As the population of elderly increases, the number of andropause also increases. Andropause is characterized by the decrease of testosteron level which is accompanied by hypogonadism symptoms. Many studies mentioned that decreased testosterone level will contribute to inflammation state, one of the cytokine is TNF-α, which then lead to many chronic inflammation disorders and influence the quality of life. Understanding the significant correlation between androgen and inflammation allows accurate consideration making in using androgen replacement therapy, therefore the quality of life will be improved significantly.This research was an analytical cross-sectional study. Subjects were recruited through random sampling at Denpasar in 2019. TNF-α serum level was measured by human immunoassay method. Andropause was measured by ADAM questionnaire and confirmed by total decreased testosterone serum level. Quality of life was measured by WHOQOL-BREF questionnaire which was then continued by bivariate and multivariate analysis to control the confounding variables. It was considered statistically significant if P value is more than 0.05. There were 60 elderly involved as research subjects consisting of 43 andropause cases and 17 non andropause cases. There was significant correlation between TNF-α serum and quality of life. This study also found that there was significant difference in quality of life between andropause and non andropause group. This study shows that there was significant correlation between TNF-α serum level and andropause with quality of life in elderly.

References

Ahern, T., Frederik, C. W. W. (2015). New horizons in testosterone and the ageing male. Age and Ageing; 44(2): 188-195.

Chin, K., Ima-Nirwana, S. (2017). The effects of testosteron deficiency and its replacement on inflammatory markers in rats: a pilot study. Int J Endocrinol Metab;15(1):e43053.

Corcoran, M., Meydani, M., Lichtenstein, A., Schaefer, E., Dillard, A., Lamon-Fava, S. (2010). Sex Hormone Modulation of Proinflammatory Cytokine and C-reactive Protein Expression in Macrophages from Older Men and Postmenopausal Women. J Endocrinol; 206(2):217-224.

Ebrahimi, F., Christ-Crain, M. (2016). Metabolic syndrome and hypogonadism – two peas in a pod. Swiss Med Wkly;146:w14283.

Gonzalo-Calvo, D., Neitzert, K., Fernandez, M., Vega-Naredo, I. (2010). Differential inflammatory responses in aging and diseases: TNF-α and IL-6 as possible biomarkers. Free Radical Biology & Medicine; 49:733-737.

Hong, C. Y., Park, J. H., Ahn, R. S., Im, S. Y., Choi, H., Soh, J., Mellon, S. H., et al. (2004). Molecular Mechanism of Suppression of Testicular Steroidogenesis by Proinflammatory Cytokine Tumor Necrosis Factor Alpha. Mol Cell Biol; 24(7):2593-2604.

Kementrian Kesehatan RI. Pusat Data dan Informasi. (2017). Analisis Lansia di Indonesia. [cited 2018, Agustus 10]. Available at: http://www.depkes.go.id/download.php?file.../Analisis%20Lansia%20Indonesia%202017

Koelman, L., Pivovarova-Ramich, O., Pfeiffer, A., Grune, T., Aleksandrova, K. (2019). Cytokines for evaluation of chronic inflammatory status in ageing research: reliability and phenotypic characterisation. Immunity & Ageing; 16: 11.

Liu, Z., Liu, J., Fu, Q. (2017). Comparing calculated free testosterone with total testosterone for screening and diagnosing late-onset hypogonadism in aged males: A cross-sectional study. J Clin Lab Anal; 31(5): e22073.

Mohammad, N., Wong, S.K., Hasan, W.N.W., Jolly, J.J., Nur-Farhana, M.F., Ima-Nirwana, S., Chin, K. (2018). The relationship between circulating testosterone and inflammatory cytokines in men. Aging Male; 1-21.

Moncada, I. (2006). Testosterone and men’s quality of life. The Aging Male; 9(4):189-193.

Novak, A., Brod, M., Elbers, J. (2002). Andropause and quality of life: findings from patient groups and clinical experts. Maturitas;43:231-237.

Nugroho, W. (2008). Keperawatan Gerontik dan Geriatrik. Edisi 3. Jakarta: Balai Penerbit EGC.

Pangkahila, W. (2017). Tetap Muda, Sehat, dan Berkualitas Konsep Anti-Aging Medicine. Jakarta: Penerbit Buku Kompas.

Roediger, A., Marucci, M., Duim, E., Santos, J., Duarte, Y., Oliveira, C. (2019). Inflammation and quality of life in later life: findings from the health, well-being, and aging study (SABE). Health and Quality of Life Outcomes; (17)26:1-7.

Salim, O.C., Sudharma, N.I., Kusumaratna, R.K., Hidayat, A. (2007). Validitas dan reliabilitas World Health Organization Quality of Life-BREF untuk mengukur kualitas hidup lanjut usia. Universa Medicina;26:27-38.

Samaras, N., Frangos, E., Forster, A. (2012). Andropause: A review of the definition and treatment. European Geriatric Medicine;3:368-373.

Soewondo, P. (2006). Menopause, andropause, dan somatopause: perubahan hormonal pada proses menua. In: Sudoyo, A.W. (eds). Buku Ajar Ilmu Penyakit Dalam Jilid III Edisi IV. Jakarta: FKUI, hal:1989-1992.

Taher, A. (2005). Proportion and Acceptance of Andropause Symptoms Among Elderly Men: A Study in Jakarta. Indones J Intern Med; 37: 82-86.

Trost, L. W., Mulhall, J. P. (2016). Challenges in Testosterone Measurement, Data, Interpretation, and Methodological Appraisal of Interventional Trials. J Sex Med; 13(7): 1029-1046.