How Much BMI and Physical Activity Level Induce Elevated Uric Acid?
Abstract
Gout is a disease by elevated uric acid that is categorized as a degenerative disease by process of decreasing organ function which generally occurs in old age but can also occur in adulthood due to decreased health status. The epidemiological studies showed that a high BMI triggers risk factors for lifestyle-related diseases such as type 2 diabetes, cardiovascular disease, cancer, and high uric acid. The other finding stated that regular exercise produces an immunomodulatory effect, which may contribute to health benefits. Despite the high prevalence of gout and evidence that underscores the benefits of physical activity in rheumatic diseases, there has been no discussion about the link between Body Mass Index (BMI), physical activity and elevated uric acid. The main objective is to analyze the body mass index and level of activity on uric acid levels, and the first specific objective is to describe the characteristics of the responden. The study conducted in Martapura 1 Public Health Center by an observational cross sectional design using linear regression models. Thirty respondents were collected using simple random sampling and questionnaire containing the result of BMI, physical activity level and uric acid was used to measure the data. There is a significant effect between BMI and physical activity together on uric acid levels. The BMI value obtained f count > f table (3.800 > 2.0484) means that partially BMI has a positive effect on uric acid. Physical activity value obtained f count > f table (-1.610 <2.0484) means H0 is accepted Conclusions: Research showed that an increase in BMI can increase uric acid levels by controlling variabel of physical activity (B=0,27, P=0.001 in BMI; B=-0.002, P=0.119 in physical activity).
References
Benatti FB, Pedersen BK. (2015). Exercise as an anti-inflammatory therapy for rheumatic diseases-myokine iregulation. NatRevRheumatol, 11:86–97.
Dharmansyah, D., & Budiana,D (2021). Indonesian Adaptation of The International Physical Activity Questionnaire (IPAQ): Psychometric Properties. Jurnal Pendidikan Keperawatan Indonesia.7(2):159-163
Ezzati M, Lopez AD, Rodgers A, Vander Hoorn S, Murray CJ. (2002). Comparative Risk Assessment Collaborating Group. Selectedmajor risk factors and global and regional burden of disease. Lancet, 360:1347–60.
George C, Minter DA. (2023) Hyperuricemia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. Available from: https://www.ncbi.nlm.nih.gov/books/NBK459218/
Gherghina M-E, Peride I, Tiglis M, Neagu TP, Niculae A, Checherita IA. (2022). Uric Acid and Oxidative Stress—Relationship with Cardiovascular, Metabolic, and Renal Impairment. International Journal of Molecular Sciences, 23(6):3188. https://doi.org/10.3390/ijms23063188
Hadano S, Ito A, Sasaki S. (1988). Effects of exercise intensity on purine catabolism. Jpn J Phys Fitness Sports Med, 37: 225-233.
Hinkle JL, Chever KH, Kristen JO. (2022). Brunner & Sddarth’s Textbook of Medical-Surgical Nursing 15th Edition. Philedelphia: Wolters Kluwer
Holla J, Fluit M, VanSchaardenburg D, et al. (2009). Recreational exercisein rheumatic diseases. Int J Sports Med,30:814–20.
Honan L. (2019). Focus on Adulth Helath Medical-Surgical Nursing Second Edition. Philedelpia: Wolters Kluwer.
Jablonski K, YoungNA, HenryC, CautionK, KalyanasundaramA, OkaforI, et al. (2020). Physical activity prevents acute inflammation in agout modelby down regulation of TLR2 on circulating neutrophils as well as inhibition of serum CXCL1 and is associated with decreased pain and inflammationin gout patients. PLoSONE, 15(10):e0237520.
Jonsson H, Aspelund T, Eiriksdottir G, Harris TB, Launer LJ, Gudnason V (2019) Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik Study. PLoS ONE 14(8): e0221474. https://doi.org/10.1371/journal.pone.0221474Klongthalay S, Suriyaprom K. Increased Uric Acid and Life Style Factors Associated with Metabolic Syndrome in Thais. Ethiop J Health Sci, 30(2):199-208. doi: 10.4314/ejhs.v30i2.7. PMID: 32165809; PMCID: PMC7060378.
Kashyap K. (2012) Comparative evaluation and correlation of different an-thropometric indices with blood pressure in adult populations. Int J Basic Appl Physiol,1(1):36- 41.
Kemenkes. (2013). Kamus: kumpulan dari beberapa istilah dan pengertian yang berhubungan dengan kesehatan. https://www.kemkes.go.id/index.php
Kuriyama S, Nakano T, Maruyama Y, et al (2014). Relationship be-tween serum uric acid levels and muscle strength/volume: a new insight from a large-scale survey. Nihon Jinzo Gakkai Shi, 56(8):1260- 1269.
Kusmayanti GAD, Dewantari NM. (2017). The influence of low purine diet an physical activity on changing uric acid levels in hyperuricemia. International Journal of Helath Sciences,1(3):1-9.
Lin X, Wang X, Li X, Song L, Meng Z, Yang Q, Zhang W, Gao Y, et al. (2019). Gender and age specific differences in the association of Hyperuricemia and Hypertension: A cross-sectional study. International Jurnal of Endocrinology.
Liu DM, Jiang LD, Gan L, et al. (2018). Associaton between the serum uric acid level and the body mass index in sex- and age-specific group in southwestern china. Endocrine Practice Rapid Electronic Article in Press.
Miftahul Rohmah, E.P (2020). Kadar Asam Urat pada Individu Dengan Obesitas. Volume 5 No.2
Nishida Y, Iyadomi M, Higaki Y, Tanaka H, Hara M, Tanaka K. (2011). Influance of physical activity intensity and aerobic fitness on the anthropometric index and serum uric acid concentration on people with obesity. Intern Med,50: 2121-2128
Prasetyawan RD. Hidayati N. (2018). The correlation between intensity of physical activity and uric acid level in gouth arthrtits patients in the sobo public health care banyu wangi. The 4th International conference on Nursing (ICON)
Santoso BN, Suwangto EG, Iryaningrum MR. (2021). The association between knowledge about gout arthritis with NSAID and allopurinol consumption in Rumah Susun Penjaringan. Rev Prim Care Prac and Educ. 4(1): 18-22
Soori H, Rezapoor P, Najafimehr H, Alirezaei T, Irilouzadian R. (2022). Comparative analysis of anthropometric indices with serum uric acid in Iranian healthy population. J Clin Lab Anal,36:e24246.
Usman SY, Darmawan G, Hamijoyo L, Wachjudi, RG. (2019). Hyperuricemia prevalence and metabolic syndrome profiles: a pilot cross sectional study in north regency, West Kalimantan, Indonesia. Indonesian Journal of Rheumatology, 11(2).
Wiseman M. (2008). The second World Cancer Research Fund/AmericanInstitute for Cancer Research expert report. Food, nutrition,physical activity, and the prevention of cancer: a global per-spective. Proc Nutr Soc,67:253–6.
Zhang L, Li Jl, Zhang Ll, Guo Ll, Li H, Li D. (2020). Body mass index and serum uric acid level: Individual and combined effects on blood pressure inmiddle-aged and older individuals in China. Medicine,99(9):e19418.
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