Gambaran Manajemen Nyeri Penderita Hiperuricemia

Budi Hartono; Khara Christy Margaretha Likumahua; Arwyn Weynand Nusawakan; Maria Dyah Kurniasari

doi:10.37287/jlh.v5i2.4032

Budi Hartono Universitas Kristen Satya Wacana
Khara Christy Margaretha Likumahua Universitas Kristen Satya Wacana
Arwyn Weynand Nusawakan Universitas Kristen Satya Wacana
Maria Dyah Kurniasari Universitas Kristen Satya Wacana

DOI: https://doi.org/10.37287/jlh.v5i2.4032

Keywords: asam urat, hiperurisemia, manajeman nyeri, nyeri sendi

Abstract

Hiperurisemia merupakan gangguan metabolisme yang ditandai oleh peningkatan kadar asam urat dalam darah, yang dapat mengakibatkan nyeri berkepanjangan, gangguan tidur, serta penurunan fungsi fisik dan kualitas hidup. Manajemen nyeri pada penderita hiperurisemia sangat penting. Penelitian ini bertujuan untuk mengidentifikasi upaya manajemen nyeri yang dilakukan oleh penderita hiperurisemia di Kampung Tegirolo, Kabupaten Sorong Selatan, Indonesia, dan dampaknya terhadap penurunan skala nyeri. Metode penelitian ini bersifat kuantitatif dengan pendekatan cross-sectional, melibatkan 49 sampel yang ditentukan dengan metode purposive sampling yaitu dengan mempertimbangkan kriteria inkulisi dalam penelitian seperti partisipan dengan asam urat tinggi, adanya keluhan nyeri, dan usia 19-59 tahun. Data dikumpulkan menggunakan kuesioner APS-POQ-R dan dianalisis secara deskriptif. Instrumen penilaian APS-POQ-R yang digunakan adalah versi Indonesia yang telah diuji kesahihan dengan nilai 0,8-1 angka V ge; 0,5 sehingga dapat digunakan dalam penelitian ini. Hasil menunjukkan bahwa rata-rata nyeri terendah adalah 4,33 (SD=1,38) dan tertinggi 8,29 (SD=1,08). Seluruh responden menggunakan manajemen nyeri, baik farmakologi maupun non-farmakologi, dengan efektivitas tinggi (rata-rata keefektifan 70,00, SD=12,42). Responden melaporkan penurunan nyeri yang signifikan melalui kedua metode ini. Kesimpulan: Peran aktif tenaga kesehatan dalam menggabungkan metode farmakologi dan non-farmakologi diperlukan untuk mencapai hasil optimal, mengingat banyak responden tidak mendapatkan anjuran non-farmakologi dari tenaga medis.

References

Amalina D, N. (2015). Gout and Hiperurisemia. Jurnal Majorty, 4.

Andarmoyo, S. (2013). Konsep & Proses Keperawatan Nyeri. Nyeri.

Anggeriyane, E., Arsilia, R., Zulfah, N. K., Amilin, N. A. R., Ananda, S., Syamsodinor, S., & Patmisari, B. (2024). The Penelitian Kasus: Pengaruh Pemberian Kompres Hangat terhadap Skor Barthel Index Lansia dengan Gangguan Rasa Nyaman. Jurnal Keperawatan Suaka Insan (JKSI), 9(1). https://doi.org/10.51143/jksi.v9i1.406

Antik, K. (2020). Hubungan Tingkat Nyeri dengan kualitas tidur pada pasien post operasi di rumah sakit tingkat III Baladhika Husada Jember. Program Studi Sarjana Keperawatan Fakultas Keperawatan Universitas Jember.

Ariastuti, R., Anam, K., & Pamungkas, I. Y. (2018). Efektivitas Analgesik Daun Gatal (Laportea Decumana) Pada Penderita Myalgia Di Kampung Atsj Distrik Atsj Kabupaten Asmat Provinsi Papua. Jurnal Kebidanan, 10(01). https://doi.org/10.35872/jurkeb.v10i01.298

Arjani, I. (2018). Gambaran Kadar Asam Urat, Glukosa Darah Dan Tingkat Pengetahuan Lansia Di Desa Samsam Kecamatan Kerambitan Kabupaten Tabanan. Meditory: The Journal Of Medical Laboratory, 6(1), 46-55.

Bambungan, Y. M., & Lerebulan, E. F. (2023). Efek Analgetik Ekstrak Daun Gatal (Laportea decumana Roxb. Wedd) pada Mencit Jantan (Mus Muscullus L.) yang Diinduksi Asam Asetat: Penelitian Hewan Coba. Health Information: Jurnal Penelitian, 15(1).

Bassiouni, S. A. R. A. K., El Adalany, M. A., Abdelsalam, M., & Gharbia, O. M. (2021). Association of serum uric acid with clinical and radiological severity of knee osteoarthritis in non-gouty patients. Egyptian Rheumatology and Rehabilitation, 48(1). https://doi.org/10.1186/s43166-020-00055-w

Becker, W. C., Dorflinger, L., Edmond, S. N., Islam, L., Heapy, A. A., & Fraenkel, L. (2017). Barriers and facilitators to use of non-pharmacological treatments in chronic pain. BMC Family Practice, 18(1). https://doi.org/10.1186/s12875-017-0608-2

Benedetti, F., Mayberg, H. S., Wager, T. D., Stohler, C. S., & Zubieta, J. K. (2005). Neurobiological mechanisms of the placebo effect. Journal of Neuroscience, 25(45). https://doi.org/10.1523/JNEUROSCI.3458-05.2005

Bingel, U., Wanigasekera, V., Wiech, K., Mhuircheartaigh, R. N., Lee, M. C., Ploner, M., & Tracey, I. (2011). The effect of treatment expectation on drug efficacy: Imaging the analgesic benefit of the opioid remifentanil. Science Translational Medicine, 3(70). https://doi.org/10.1126/scitranslmed.3001244

Botti, M., Khaw, D., Jørgensen, E. B., Rasmussen, B., Hunter, S., & Redley, B. (2015). Cross-Cultural Examination of the Structure of the Revised American Pain Society Patient Outcome Questionnaire (APS-POQ-R). Journal of Pain, 16(8). https://doi.org/10.1016/j.jpain.2015.03.016

Bushnell, M. C., Frangos, E., & Madian, N. (2021). Non-pharmacological Treatment of Pain: Grand Challenge and Future Opportunities. In Frontiers in Pain Research (Vol. 2). https://doi.org/10.3389/fpain.2021.696783

Chandratre, P., Mallen, C., Richardson, J., Muller, S., Hider, S., Rome, K., Blagojevic-Bucknall, M., & Roddy, E. (2018). Health-related quality of life in gout in primary care: Baseline findings from a cohort study. Seminars in Arthritis and Rheumatism, 48(1). https://doi.org/10.1016/j.semarthrit.2017.12.005

Chandratre, P., Roddy, E., Clarson, L., Richardson, J., Hider, S. L., & Mallen, C. D. (2013). Health-related quality of life in gout: A systematic review. Rheumatology (United Kingdom), 52(11). https://doi.org/10.1093/rheumatology/ket265

Cheng-yuan, W., & Jian-gang, D. (2023). Research progress on the prevention and treatment of hyperuricemia by medicinal and edible plants and its bioactive components. In Frontiers in Nutrition (Vol. 10). https://doi.org/10.3389/fnut.2023.1186161

Chintyawati, C. (2018). “Hubungan Antara Nyeri Reumatoid Artritis Dengan Kemandirian Dalam Aktivitas Kehidupan Sehari-Hari Pada Lansia Di Posbindu Karang Mekar Wilayah Kerja Puskesmas Pisangan Tangerang Selatan Tingkat.” Institutional Pepository UIN Syarif Hidayatullah Jakarta.

Cicero, A. F. G., Fogacci, F., Kuwabara, M., & Borghi, C. (2021). Therapeutic strategies for the treatment of chronic hyperuricemia: An evidence-based update. In Medicina (Lithuania) (Vol. 57, Issue 1). https://doi.org/10.3390/medicina57010058

Comberg, H.-U., & Schach, S. (2016). Hyperuricemia is Associated with Musculo-skeletal Pain - Results from a Cross-sectional Study. The Open Pain Journal, 9(1). https://doi.org/10.2174/1876386301609010015

Dincer, H. E., Dincer, A. P., & Levinson, D. J. (2023). Asymptomatic hyperuricemia: to treat or not to treat. Cleveland Clinic journal of medicine, 69(8), 594-608. https://my.clevelandclinic.org/health/diseases/17808-hyperuricemia-high-uric-acid-level

Ekadana Prayoga Suryadi, Keith Justine Thiotansen, Reynaldi Hardianto Saputra, Priscilla Angeline, & Novia Yolanda. (2022). Colchicine – from Gout to Covid-19. Journal for Quality in Public Health, 5(2). https://doi.org/10.30994/jqph.v5i2.385

Ernst, L. S., & Ferrer, L. (2009). Reflection of a 7-Year Patient Care Program. Journal of Holistic Nursing, 27(4). https://doi.org/10.1177/0898010109339526

Firgita Lasido, Rona Febriyona, & Andi Nur Aina Sudirman. (2023). Pengaruh Pemberian Air Rebusan Daun Sirsak Terhadap Penurunan Kadar Asam Urat Lansia Di Desa Iloheluma Kec.Boliyohuto. Jurnal Rumpun Ilmu Kesehatan, 3(1). https://doi.org/10.55606/jrik.v3i1.1237

Galih, R. (2019). In vitro Investigation of Proposed Anti-Inflammatory Properties Originating from Daun Gatal (Laportea decumana) Hexane Extract (Doctoral dissertation, Indonesia International Institute for Life Sciences).

Gordon, D. B., Polomano, R. C., Pellino, T. A., Turk, D. C., McCracken, L. M., Sherwood, G., Paice, J. A., Wallace, M. S., Strassels, S. A., & Farrar, J. T. (2010). Revised american pain society patient outcome questionnaire (aps-poq-r) for quality improvement of pain management in hospitalized adults: Preliminary psychometric evaluation. Journal of Pain, 11(11). https://doi.org/10.1016/j.jpain.2010.02.012

Gumilang, M. (2019). Gambaran Tingkat Pengetahuan Mahasiswa Profesi Ners Universitas Diponegoro tentang Manajemen Nyeri. Skripsi.

Haruyama, Shiego. 2014. The Miracle of Endhorphin Sehat Mudah dan Praktis Dengan Hormon Kebahagiaan. Bandung: Mizan Pustaka.

Hasibuan, D. C., & Simamora, F. A. (2020). Efektifitas Rebusan Daun Sirsak Terhadap Penurunan Skala Nyeri Pada Penderita Gout Arthritis. Jurnal Kesehatan Ilmiah Indonesia (Indonesian Health Scientific Journal), 5(2). https://doi.org/10.51933/health.v5i2.319

Herman, H., Sukmawati, S., & Pranada, A. D. (2021). Perbandingan Efikasi Dan Keamanan Penggunaan Febuxostat Dan Allopurinol Pada Pasien Gout. Jurnal Ilmiah As-Syifaa, 13(1). https://doi.org/10.33096/jifa.v13i1.764

Irawan, H., Santoso, P., & Pridanatama, A. (2020). Pengaruh Terapi Bekam Terhadap Skala Nyeri Pada Klien Gout Di Bilik Bekam Desa Sidomulyo Kecamatan Semen Kabupaten Kediri. Judika (Jurnal Nusantara Medika), 4(2). https://doi.org/10.29407/judika.v4i2.15378

Italia, & Neska, E. T. (2022). Pengaruh Terapi Kompres Hangat Terhadap Penurunan Nyeri Sendi Osteoarthritis Pada Lansia. Jurnal Kesehatan Dan Pembangunan, 12(23).

Ito, S., Torii, T., Nakajima, A., Iijima, T., Murano, H., Horiuchi, H., Yamanaka, H., & Honda, M. (2020). Prevalence of gout and asymptomatic hyperuricemia in the pediatric population: a cross-sectional study of a Japanese health insurance database. BMC Pediatrics, 20(1). https://doi.org/10.1186/s12887-020-02379-0

Jeong, H. J., Park, W. Y., Kim, S. H., Dalbeth, N., & Son, C. N. (2022). Urate-lowering efficacy and renal safety of febuxostat in patients with hyperuricemia and stage 4–5 chronic kidney disease not yet on dialysis: A meta-analysis of observational studies. Seminars in Arthritis and Rheumatism, 56. https://doi.org/10.1016/j.semarthrit.2022.152073

Jiang, T., Weng, Q., Zhang, Y., Zhang, W., Doherty, M., Sarmanova, A., Hall, M., Yang, Z., Li, J., Yang, T., Zeng, C., Wei, J., & Lei, G. (2022). ASSOCIATION BETWEEN HYPERURICEMIA AND ULTRASOUND-DETECTED KNEE SYNOVIAL ABNORMALITY: DATA FROM THE XIANGYA OSTEOARTHRITIS (XO) STUDY. Osteoarthritis and Cartilage, 30. https://doi.org/10.1016/j.joca.2022.02.354

Jonsson, H., Aspelund, T., Eiriksdottir, G., Harris, T. B., Launer, L. J., & Gudnason, V. (2019). Hyperuricemia is associated with intermittent hand joint pain in a cross sectional study of elderly females: The AGES-Reykjavik study. PLoS ONE, 14(8). https://doi.org/10.1371/journal.pone.0221474

Karimah, S. K., Putra, K. W. R., Huda, N., & Sulistyowati, A. (2021). ASUHAN KEPERAWATAN PADA Ny. K DENGAN MASALAH KEPERAWATAN NYERI AKUT PADA DIAGNOSA MEDIS ASAM URAT DI KELURAHAN GEMPENG BANGIL KABUPATEN PASURUAN (Doctoral dissertation, Politeknik Kesehatan Kerta Cendekia).

Kementerian Kesehatan RI. (2018). Riskesdas 2018. Laporan Nasional Riskesdas 2018, 44(8).

Kusumaningati, R. W. (2017). “Uji Kesahihan American Pain Society Patient Outcome Questionnaire Revised (APS-POQ-R) Versi Indonesia untuk Menilai Kualitas Manajemen Nyeri Pascabedah di RSUPN Cipto Mangunkusumo”=“Validity Test of The Indonesian Version of The Revised American Pain Society Patient Outcome Questionnaire (APS-POQR) to Evaluate The Quality of Postoperative Pain Management in RSCM”.

Kuzmina, G. P., & Lazarenko, O. M. (2020). Features Of Impact Of Hyperferritinemia In Combination With Hyperuricemia On The Course Of Gout. Medicni Perspektivi, 25(1). https://doi.org/10.26641/2307-0404.2020.1.200414

Li, Q., Li, X., Wang, J., Liu, H., Kwong, J. S. W., Chen, H., Li, L., Chung, S. C., Shah, A., Chen, Y., An, Z., Sun, X., Hemingway, H., Tian, H., & Li, S. (2019). Diagnosis and treatment for hyperuricemia and gout: A systematic review of clinical practice guidelines and consensus statements. In BMJ Open (Vol. 9, Issue 8). https://doi.org/10.1136/bmjopen-2018-026677

Liu, Y. (2022). Treatment of Hyperuricemia and Gout-related Diseases with Complementary and Alternative Medicine.

LPB Balitbangkes. (2018). Laporan Provinsi Papua Barat Riskesdas 2018. In Laporan Riskesdas 2018.

Lutfiani, A., & Baidhowy, A. S. (2022). Penerapan Kompres Hangat Jahe Merah Terhadap Manajemen Nyeri Pada Pasien Gout Arthritis. Holistic Nursing Care Approach, 2(2). https://doi.org/10.26714/hnca.v2i2.9855

Maria Q. (2017).Profil Penggunaan Obat Hiperurisemia dan Gout di Instalasi Farmasi Rawat Jalan Rumah Sakit Umum Daerah Koja Periode Oktober - Desember 2016.(Electronic Thesis or Dissertation). Retrieved from https://localhost/setiadi

Marnah, M., Husaini, H., & Ilmi, B. (2017). Analisis Perilaku Masyarakat Dalam Pemanfaatan Pelayanan Kesehatan Peserta Program Keluarga Harapan (Pkh) Di Kecamatan Paminggir. Jurnal Berkala Kesehatan, 1(2). https://doi.org/10.20527/jbk.v1i2.3152

Mayasari, C. D. (2016). Pentingnya pemahaman manajemen nyeri non farmakologi bagi seorang perawat. Wawasan Kesehatan, 1(1), 35-42.

Mitra, S., Jain, K., Singh, J., Jindal, S., Saxena, P., Singh, M., Saroa, R., Ahuja, V., Kang, J., & Garg, S. (2020). Does an acute pain service improve the perception of postoperative pain management in patients undergoing lower limb surgery? A prospective controlled non-randomized study. Journal of Anaesthesiology Clinical Pharmacology, 36(2). https://doi.org/10.4103/joacp.JOACP_104_19

Muthiah, D., Illahi, R. K., Pramestutie, H. R., & Sidharta, B. (2020). Pengaruh Konseling Apoteker Terhadap Tingkat Pengetahuan Pasien Gout Dalam. Pharmaceutical Journal of Indonesia, 5(2).

NA'U, I. N. G. G. R. I. D. (2022). Studi Kasus: Terapi Musik Gamelan Untuk Menurunkan Skala Nyeri Pada Pasien Post Op Fraktur Hari Pertama Di Ruang Flamboyan Rumah Sakit Bethesda Yogyakarta (Doctoral dissertation, STIKES Bethesda Yakkum Yogyakarta).

Nibbelink, C. W., & Brewer, B. B. (2018). Decision-making in nursing practice: An integrative literature review. In Journal of Clinical Nursing (Vol. 27, Issues 5–6). https://doi.org/10.1111/jocn.14151

Nicholls, A., Snaith, M. L., & Scott, J. T. (1973). Effect of Oestrogen Therapy on Plasma and Urinary Levels of Uric Acid. British Medical Journal, 1(5851). https://doi.org/10.1136/bmj.1.5851.449

Niederstrasser, N. G., & Attridge, N. (2022). Associations between pain and physical activity among older adults. PLoS ONE, 17(1 January). https://doi.org/10.1371/journal.pone.0263356

Nori, W., Kassim, M. A. K., Helmi, Z. R., Pantazi, A. C., Brezeanu, D., Brezeanu, A. M., Penciu, R. C., & Serbanescu, L. (2023). Non-Pharmacological Pain Management in Labor: A Systematic Review. In Journal of Clinical Medicine (Vol. 12, Issue 23). https://doi.org/10.3390/jcm12237203

Novianti. (2015). Hidup Sehat Tanpa Asam Urat. In Buku Pintar (Vol. 13).

Paisey, E. K., Muyan, Y., Edowai, D. N., & Dailami, M. (2017). Genetic Analysis of Itchy Leaves (<i>Laportea</i>, sp) in Papua for Herbal Medicinal Products as Development of Studying Economics Value. Natural Science, 09(02). https://doi.org/10.4236/ns.2017.92004

Paulson, H., & Smith, E. L. (2016). Top 10 treatment principles to quell the pain of gout. Consultant, 56(9).

Pera, Y., Desi, D., & Dese, D. C. (2021). Deskripsi Perilaku Kesehatan (Health Behavior) Dan Kualitas Hidup Lansia Suku Dayak Tomun Di Desa Sungai Buluh, Kab. Lamandau, Prov. Kalimantan Tengah. Jurnal Keperawatan Muhammadiyah, 6(2). https://doi.org/10.30651/jkm.v6i1.7671

PPNI. (2018). Standar Diagnosa Keperawatan Indonesia : Defisini dan Indikator. In Keperawatan (Vol. 9).

Pratama, K. N., Rahayu, E., Awaludin, S., Setiawati, N., & Purnamasari, M. D. (2020). Buku Panduan Praktikum - Mata Kuliah Keperawatan Komplementer. Buku Panduan Praktikum.

Pribadi, T., Rahma, A., & Yulendasari, R. (2021). Pemberian Akupresur Untuk Menurunkan Nyeri Dan Kadar Asam Urat Pada Klien Asam Urat Di Poncowarno Kecamatan Kalirejo Lampung Tengah. Jurnal Kreativitas Pengabdian Kepada Masyarakat (Pkm), 4(3). https://doi.org/10.33024/jkpm.v4i3.2842

Puntillo, F., Giglio, M., Paladini, A., Perchiazzi, G., Viswanath, O., Urits, I., Sabbà, C., Varrassi, G., & Brienza, N. (2021). Pathophysiology of musculoskeletal pain: a narrative review. In Therapeutic Advances in Musculoskeletal Disease (Vol. 13). https://doi.org/10.1177/1759720X21995067

Radharani, R. (2020). Kompres Jahe Hangat dapat Menurunkan Intensitas Nyeri pada Pasien Gout Artritis. Jurnal Ilmiah Kesehatan Sandi Husada, 9(1), 573-578.

Ragab, G., Elshahaly, M., & Bardin, T. (2017). Gout: An old disease in new perspective – A review. In Journal of Advanced Research (Vol. 8, Issue 5). https://doi.org/10.1016/j.jare.2017.04.008

Rahmah, A. (2019). Efektifitas Pijat Refleksi Dan Pijat Tubuh Terhadap Asam Urat Darah Dan Skala Nyeri Pada Pasien Hiperurisemia Di Ciledug. In Jurnal Skolastik Keperawatan (Vol. 5, Issue 1).

Raja, S. N., Carr, D. B., Cohen, M., Finnerup, N. B., Flor, H., Gibson, S., Keefe, F. J., Mogil, J. S., Ringkamp, M., Sluka, K. A., Song, X. J., Stevens, B., Sullivan, M. D., Tutelman, P. R., Ushida, T., & Vader, K. (2020). The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises. In Pain (Vol. 161, Issue 9). https://doi.org/10.1097/j.pain.0000000000001939

Riddle, D. L., Pulisic, M., Pidcoe, P., & Johnson, R. E. (2003). Risk factors for plantar fasciitis: A matched case-control study. Journal of Bone and Joint Surgery, 85(5). https://doi.org/10.2106/00004623-200305000-00015

Rumengan, D. S. S., Umboh, J. M. L., & 2, G. D. K. (2015). Faktor-Faktor yang Berhubungan dengan Pemanfaatan Pelayanan Kesehatan Pada Peserta BPJS Kesehatan di Puskesmas Paniki Bawah Kecamatan Mapanget Kota Manado. JIKMU, Suplemen, 5.

Sahai, R., Kumar Sharma, P., Misra, A., & Dutta, S. (2020). Pharmacology of the Therapeutic Approaches of Gout. In Recent Advances in Gout. https://doi.org/10.5772/intechopen.85717

Sahrudi, S., Maria, R., & Herawati, T. (2019). Nyeri Lutut Berpengaruh terhadap Kemampuan Fungsi Fisik Pasien dengan Osteoarthritis Lutut. Jurnal Ilmu Dan Teknologi Kesehatan, 7(1). https://doi.org/10.32668/jitek.v7i1.215

Santi, H. (2022). Gambaran Penanggulangan Nyeri Haid Desminore Remaja Putri di STIKes Kendal. Care Journal, 1(2). https://doi.org/10.35584/carejournal.v1i2.34

Sari, L. T., & Suminar, E. (2020). Pengaruh Terapi Komplementer “Meditasi” terhadap Penurunan Intensitas Nyeri Premenstrual Syndrom pada Remaja Putri Usia 16-18 Tahun di Kelompok Remaja Desa Jatinom Blitar. Jurnal Ners Dan Kebidanan (Journal of Ners and Midwifery), 7(2). https://doi.org/10.26699/jnk.v7i2.art.p270-275

Scirè, C. A., Manara, M., Cimmino, M. A., Govoni, M., Salaffi, F., Punzi, L., Monti, M. C., Carrara, G., Montecucco, C., Matucci-Cerinic, M., Minisola, G., Galossi, A., Lauriti, C., Fracassi, E., Selvi, E., Tirri, E., Furini, F., Inverardi, F., Porta, F., … Veneto, V. (2013). Gout impacts on function and health-related quality of life beyond associated risk factors and medical conditions: Results from the KING observational study of the Italian Society for Rheumatology (SIR). Arthritis Research and Therapy, 15(5). https://doi.org/10.1186/ar4281

Shi, Y., & Wu, W. (2023). Multimodal non-invasive non-pharmacological therapies for chronic pain: mechanisms and progress. In BMC Medicine (Vol. 21, Issue 1). https://doi.org/10.1186/s12916-023-03076-2

Simaremare, E. S. (2014). Skrining Fitokimia Ekstrak Etanol Daun Gatal (Laportea decumana (Roxb.) Wedd). Pharmacy, 11(01).

Simaremare, E. S., & Souisa, W. V. (2021). Uji Aktivitas Antihiperurisemia Ekstrak Daun Gatal (Laportea decumana (Roxb.) Wedd) Asal Papua. Pharmauho: Jurnal Farmasi, Sains, Dan Kesehatan, 7(1). https://doi.org/10.33772/pharmauho.v7i1.14966

Simaremare, E. S., Gunawan, E., & Yabansabra, Y. R. (2020). Evaluation of pharmacological activities of itchy leaf extracts (Laportea decumana (Roxb.) Wedd.). International Journal of Pharmaceutical Research, 12(3). https://doi.org/10.31838/ijpr/2020.12.03.199

Simaremare, E. S., Tolip, M. R. Y., & Pratiwi, R. D. (2022). Formulation and Effectiveness Test of Analgesic Patch from Itchy Leaves (Laportea decumana (Roxb.) Wedd). Current Applied Science and Technology, 22(3). https://doi.org/10.55003/cast.2022.03.22.008

Sulistyowati. (2019). Pengaruh Infused Water Lemon Di Posyandu Lansia Sukorejo Wonogiri Oleh : Sulistyowati Program Studi Sarjana Keperawatan. Jurnal Kesehatan, 87(1).

Sun, H.-l., Wu, Y.-W., Bian, H.-g., Yang, H., Wang, H., Meng, X.-M., Jin, J., 2021. Function of uric acid transporters and their inhibitors in hyperuricaemia. Front. Pharmacol. 12. https://doi.org/10.3389/fphar.2021.667753.

Susanty Simaremare, E., Fadhilah, R. F., Gunawan, E., Yabansabra, Y., & Holle, E. (2019). Anticoagulant Activity of Ethanolic Extract Stingging Nettle from Biak Numfor. Trends in Pharmaceuticals and Nanotechnology, 1(1).

Susanty Simaremare, E., Holle, E., Gunawan, E., Yabansabra, Y. R., Octavia, F., & Pratiwi, R. D. (2018). Toxicity, Antioxidant, Analgesic and Anti-inflamantory of Ethanol Extracts of Laportea aestuans (Linn.) Chew. Available Online Www.Jocpr.Com Journal of Chemical and Pharmaceutical Research, 10(5).

Tan, B., Wu, X., Yu, J., & Chen, Z. (2022). The Role of Saponins in the Treatment of Neuropathic Pain. In Molecules (Vol. 27, Issue 12). https://doi.org/10.3390/molecules27123956

Tang, N. K. Y. (2018). Cognitive behavioural therapy in pain and psychological disorders: Towards a hybrid future. In Progress in Neuro-Psychopharmacology and Biological Psychiatry (Vol. 87). https://doi.org/10.1016/j.pnpbp.2017.02.023

Tang, S. K., Tse, M. M. Y., Leung, S. F., & Fotis, T. (2019). The effectiveness, suitability, and sustainability of non-pharmacological methods of managing pain in community-dwelling older adults: A systematic review. In BMC Public Health (Vol. 19, Issue 1). https://doi.org/10.1186/s12889-019-7831-9

Tano, P. F., Apiribu, F., Tano, E. K., Agambire, R., Boateng, I., & Sefah, V. (2022). Patient satisfaction in the use of non-pharmacological therapies in the management of postoperative pain: a study in a tertiary hospital, Ghana. In medRxiv. https://doi.org/10.1101/2022.04.28.22274426

Teguh, S. 2014. 101 Khasiat Terapi Air Putih. Yogyakarta: Buku pintar.

Udayani, N. N. W., Wiguna, P. D. S., Cahyaningsih, E., & Wardani, I. G. A. A. K. (2023). Skrining Fitokimia dan Aktivitas Antioksidan Ekstrak Daun Benalu Jeruk (Dendrophthoe glabrescens (Blakely) Barlow) dengan Pelarut n-Heksan dan Etanol. Jurnal Ilmiah Medicamento, 9(2). https://doi.org/10.36733/medicamento.v9i2.7136

Vargas-Prada, S., & Coggon, D. (2015). Psychological and psychosocial determinants of musculoskeletal pain and associated disability. In Best Practice and Research: Clinical Rheumatology (Vol. 29, Issue 3). https://doi.org/10.1016/j.berh.2015.03.003

Wahyu W, F. (2017). Artritis Gout Dan Perkembangannya. Saintika Medika, 10(2). https://doi.org/10.22219/sm.v10i2.4182

Wesnawa, I. B. M. D. P. (2020). Evaluasi Efektivitas Pengendalian Internal Pada Instalasi Farmasi Rsud Panglima Sebaya Di Kalimantan Timur. In S1 thesis, Universitas Atma Jaya Yogyakarta.

Widiastuti, L., & Aderita, N. I. (2022). Upaya Menurunkan Nyeri Melalui Senam Ergonomis dan PemberianRebusan Daun Sirsak Pasien Gout Arthritis di Desa Sekaran. Indonesian Journal on Medical Science, 9(1).

Winda Suwandi, D., & Perdana, F. (2017). Inhibition Activity of Xanthine Oxidase of Etanol Extract of Avocado Leaves with in Vitro Method. Jurnal Ilmiah Farmako Bahari, 8(2).

Wulan, E. R. (2020). Pengaruh Terapi Minum Air Putih Terhadap Perubahan Kadar Asam Urat Darah pada Penderita Asam Urat di Desa Katipugal Kec. Kebonagung Kab. Pacitan. Skripsi Diterbitkan Oleh Porgram Studi Keperawatan Sekolah Tinggi Ilmu Kesehatan Bhakti Husada Mulia Madiun.

Yadav, S., Khandelwal, N., Nath, S. K., & Rai, S. (2023). A Hospital-Based Cross-Sectional Study of Patients With Plantar Fasciitis: Is Hyperuricemia Screening Needed? Cureus. https://doi.org/10.7759/cureus.37088

Yu, Z., Zhou, Y., Xu, X., Lin, L., Le, Q., & Gu, Y. (2023). Pharmacological and non-pharmacological interventions in management of peripheral venipuncture-related pain: a randomized clinical trial. BMC Pediatrics, 23(1). https://doi.org

Gambaran Manajemen Nyeri Penderita Hiperuricemia

Abstract

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