The Effect of Regular Exercise and Probiotic Milk Consumption on Blood Glucose Levels in Diabetes Mellitus Patients
Abstract
Diabetes Mellitus (DM) is a chronic condition characterized by elevated blood glucose levels due to defects in insulin secretion or action. Type 2 Diabetes Mellitus (T2DM) is the most prevalent form, contributing to complications such as cardiovascular diseases, neuropathy, and retinopathy. Managing T2DM often involves lifestyle changes, including physical activity and dietary adjustments. Probiotic milk, containing beneficial microorganisms, has been studied for its potential to improve glycemic control in diabetic patients. However, while exercise and probiotics have been researched separately, their combined impact on blood glucose management remains underexplored. This study aimed to assess the effects of regular exercise and probiotic milk consumption on blood glucose levels in T2DM patients. Specifically, it sought to examine blood glucose changes before and after exercise, and after consuming probiotic milk. A quasi-experimental design with a one-group pre-test post-test approach was used. Fifty participants with T2DM were recruited using purposive sampling from the SP6 Sari Bungamas Community Health Center, Lahat Regency, Indonesia. Participants engaged in light physical activity three times a week for three months. After each session, they consumed probiotic milk, and their blood glucose levels were measured pre-exercise, post-exercise, and two hours after consumption. Paired t-tests were used to analyze the data. Regular exercise significantly lowered blood glucose levels (p-value = 0.016). However, probiotic milk consumption did not show a statistically significant effect on blood glucose levels (p-value = 0.55). Regular exercise significantly reduces blood glucose levels in T2DM patients. However, the effect of probiotic milk on blood glucose levels was inconsistent, warranting further research to determine its potential benefits.
References
Alireza, Ostadrahimi., Akbar, Taghizadeh., Majid, Mobasseri., Nazila, Farrin., Laleh, Payahoo., Zahra, Beyramalipoor, Gheshlaghi., Morteza, Vahedjabbari. (2015). Effect of probiotic fermented milk (kefir) on glycemic control and lipid profile in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial.. Iranian Journal of Public Health, 44(2):228-237.
Azimeh, Hasanpour., Siavash, Babajafari., Seyed, Mohammad, Mazloomi., Mesbah, Shams. (2023). The effects of soymilk plus probiotics supplementation on cardiovascular risk factors in patients with type 2 diabetes mellitus: a randomized clinical trial. BMC Endocrine Disorders, 23(1) doi: 10.1186/s12902-023-01290-w
Bing, Li., Xiangqi, Meng., Yaru, Liu., Jiyu, Zhai., Wenjie, Wu., Yili, Xue., Ruolin, Gao., Pengyi, Zhang. (2023). Mechanism Of Lactobacillus Combined With Aerobic Exercise On Pancreatic Tgr5/pka/creb Pathway In T2dm Mice. Medicine and Science in Sports and Exercise, 55(9S):1038-1038. doi: 10.1249/01.mss.0000989496.59086.cc
Burcu, Sanal, Yilmaz. (2023). Pathogenesis of Diabetes Mellitus. 45-54. doi: 10.69860/nobel.9786053359111.5
Fanny, Perraudeau., Paul, J., McMurdie., James, H., Bullard., Andrew, T., Cheng., Colleen, Cutcliffe., Achal, Deo., John, Eid., Jessica, Gines., Mohan, S., Iyer., Nicholas, B., Justice., Wesley, T, Loo., Madeleine, Nemchek., Marcus, F., Schicklberger., Michael, Souza., Brendon, Stoneburner., Surabhi, Tyagi., Orville, G., Kolterman. (2020). Improvements to postprandial glucose control in subjects with type 2 diabetes: a multicenter, double blind, randomized placebo-controlled trial of a novel probiotic formulation. BMJ open diabetes research & care, 8(1) doi: 10.1136/BMJDRC-2020-001319
Farah, Nuriannisa., Nyoman, Kertia., Lily, Arsanti, Lestari. (2020). Efek konsumsi yogurt terhadap glukosa darah puasa pada penyandang diabetes melitus tipe 2. 8(1):40-44. doi: 10.14710/JGI.8.1.40-44
Frank, R., Spellman. (2022). Probiotics in the Management of Diabetes. 61-76. doi: 10.1007/978-981-16-8444-9_4
G., D., Fadieienko., O., G., Kurinna. (2020). The impact of probiotic nutrition in type 2 diabetes. 43-54. doi: 10.30978/UTJ2020-2-43
Hao, Feng., Xinlan, Mao., Yanying, Deng., Xiao, Bao, Wang., Qiong, Zhang., Yan, Guo., Su-Mei, Xiao. (2023). The effects of probiotics supplementation on glycaemic control among adults with type 2 diabetes mellitus: a systematic review and meta-analysis of randomised clinical trials. Journal of Translational Medicine, 21(1) doi: 10.1186/s12967-023-04306-0
Irene, Baroni., D., Fabrizi., Michela, Luciani., Arianna, Magon., G., Conte., Giada, De, Angeli., Giulia, Paglione., Davide, Ausili., Rosario, Caruso. (2024). Probiotics and synbiotics for glycemic control in diabetes: a systematic review and meta-analysis of randomized controlled trials. Clinical Nutrition, doi: 10.1016/j.clnu.2024.03.006
J., Sudagani., G.A., Hitman. (2013). Diabetes Mellitus: Etiology and Epidemiology. 40-46. doi: 10.1016/B978-0-12-375083-9.00071-4
Junichi, Okada., Eijiro, Yamada., Tsugumichi, Saito., Shuichi, Okada., Masanobu, Yamada. (2019). Analysis of variation in pre-meal exercise effect on fasting interstitial glucose level. International Journal of Diabetes in Developing Countries, 39(4):774-776. doi: 10.1007/S13410-019-00747-W
Kelly, Tiderencel., Deborah, A., Hutcheon., Jane, Ziegler. (2020). Probiotics for the treatment of type 2 diabetes: A review of randomized controlled trials.. Diabetes-metabolism Research and Reviews, 36(1) doi: 10.1002/DMRR.3213
Mariana, Pimentel, Gomes, Souza., Renata, Cristina, Machado, Mendes., Dayanna, Magalhães, dos, Reis., Maria, Yasmin, Paz, Teixeira, Martins. (2022). O efeito do uso de probióticos sobre glicemia de jejum, resistência à insulina e hemoglobina glicada em pessoas com Diabetes mellitus tipo 2: uma revisão de literatura. Research, Society and Development, 11(5):e10411527972-e10411527972. doi: 10.33448/rsd-v11i5.27972
Mohammad, Asghari, Jafarabadi., Azadeh, Dehghani., Leila, Khalili., Ali, Barzegar., Mahdi, Mesrizad., Tohid, Hassanalilou. (2021). A Meta-analysis of Randomized Controlled Trials of the Effect of Probiotic Food or Supplement on Glycemic Response and Body Mass Index in Patients with Type 2 Diabetes, Updating the Evidence.. Current Diabetes Reviews, 17(3):356-364. doi: 10.2174/1573399816666200812151029
Navya, Sreepathi., M., K., Jayanthi., Suresh, Chandra., Shrisha, Naik, Bajpe., Ramith, Ramu. (2022). Probiotic Intervention in the Treatment of Diabetes Mellitus: A Review. Journal of Pure and Applied Microbiology, 16(3):1519-1529. doi: 10.22207/jpam.16.3.25
Nazli, Namazi., Zohreh, Sajjadi, Hazaveh., Elham, Akhtari., Mohammad, Hossein, Ayati., Bagher, Larijani. (2021). The Role of Probiotics on Controlling Diabetes Mellitus: An Umbrella Review. Journal of Mazandaran University of Medical Sciences, 30(193):47-58.
Periyanaina, Kesika., Bhagavathi, Sundaram, Sivamaruthi., Chaiyavat, Chaiyasut. (2019). Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials. BioMed Research International, 2019:1531567-1531567. doi: 10.1155/2019/1531567
Periyanaina, Kesika., Bhagavathi, Sundaram, Sivamaruthi., Chaiyavat, Chaiyasut. (2019). Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials. BioMed Research International, 2019:1531567-1531567. doi: 10.1155/2019/1531567
Periyanaina, Kesika., Bhagavathi, Sundaram, Sivamaruthi., Chaiyavat, Chaiyasut. (2019). Do Probiotics Improve the Health Status of Individuals with Diabetes Mellitus? A Review on Outcomes of Clinical Trials. BioMed Research International, 2019:1531567-1531567. doi: 10.1155/2019/1531567
Pınar, Karabağlı. (2023). Classification of Diabetes Mellitus and Definitions. 9-14. doi: 10.69860/nobel.9786053359111.2
Quinten, Labuschagne., Boikgantsho, Matsaung., Kamogetso, Mametja. (2017). Overview and management of type 2 diabetes mellitus. SA Pharmaceutical Journal, 84(6):29-36.
Rafael, Vaz, Machry., Henrique, Umpierre, Pedroso., Luthiele, da, Silva, Vasconcellos., Rafaela, Ramos, Nunes., Cibelle, de, Abreu, Evaldt., Eduardo, Bardou, Yunes, Filho., Ticiana, da, Costa, Rodrigues. (2018). Multifactorial intervention for diabetes control among older users of insulin. Revista De Saude Publica, 52:60-60. doi: 10.11606/S1518-8787.2018052000144
Ralph, A., DeFronzo., Ele, Ferrannini., Leif, Groop., Robert, R., Henry., William, H., Herman., Jens, J., Holst., Frank, B., Hu., C., Ronald, Kahn., Itamar, Raz., Gerald, I., Shulman., Donald, C., Simonson., Marcia, A., Testa., Ram, Weiss. (2015). Type 2 diabetes mellitus.. 1(1):15019-15019. doi: 10.1038/NRDP.2015.19
Sabina, Paglialunga., Bruce, H., Morimoto., Amparo, de, la, Peña., Caroline, Fortier. (2018). Tracking the Sugar Rush: Incorporating Continuous Glucose Monitoring Into Multisite Early Clinical Research With Type 2 Diabetes Subjects. Clinical pharmacology in drug development, 7(7):676-683. doi: 10.1002/CPDD.437
Sachin, Rangrao, Patil., Ajinkya, B., Chavan., Ansar, M., Patel., Pranjal, Dhondiba, Chavan., Jyoti, Vilas, Bhopale. (2023). A Review on Diabetes Mellitus its Types, Pathophysiology, Epidermiology and its Global Burden. doi: 10.55544/jrasb.2.4.9
Tae, Woo, Kim. (2022). Preventive and Therapeutic Role of Probiotics in Type-2 Diabetes and Its Associated Complications. 125-141. doi: 10.1007/978-981-16-8444-9_7
Tensay, Ambelu., Getu, Teferi. (2023). The impact of exercise modalities on blood glucose, blood pressure and body composition in patients with type 2 diabetes mellitus. BMC sports science, medicine & rehabilitation, 15 doi: 10.1186/s13102-023-00762-9
Xia, Wang., Qi-Fang, Juan., Yu-Wei, He., Li, Zhuang., Yuan-Yuan, Fang., Yong-Hong, Wang. (2017). Multiple effects of probiotics on different types of diabetes: a systematic review and meta-analysis of randomized, placebo-controlled trials.. Journal of Pediatric Endocrinology and Metabolism, 30(6):611-622. doi: 10.1515/JPEM-2016-0230
Ye, Chen., Teng, Ma., Xia, Yu., Lai-Yu, Kwok., Yalin, Li., Zhihong, Sun., Dongmei, Li., Heping, Zhang. (2023). Adjunctive Probio-X Treatment Enhances the Therapeutic Effect of a Conventional Drug in Managing Type 2 Diabetes Mellitus by Promoting Short-Chain Fatty Acid-Producing Bacteria and Bile Acid Pathways. MSystems, 8(1) doi: 10.1128/msystems.01300-22
Yuying, Wang., Xiao-Zhong, Wang., Xinzhu, Xiao., Shufang, Yu., Wennan, Huang., Benqiang, Rao., Fenglin, Chen. (2023). A Single Strain of Lactobacillus (CGMCC 21661) Exhibits Stable Glucose- and Lipid-Lowering Effects by Regulating Gut Microbiota. Nutrients, 15(3):670-670. doi: 10.3390/nu15030670
Zhongke, Sun., Xuejiao, Sun., Juan, Li., Zhaoyang, Li., Qingwei, Hu., Lili, Li., Xinqi, Hao., Maoping, Song., Chengwei, Li. (2020). Using probiotics for type 2 diabetes mellitus intervention: Advances, questions, and potential. Critical Reviews in Food Science and Nutrition, 60(4):670-683. doi: 10.1080/10408398.2018.1547268
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