The Predictors of Diabetic Nephropathy in Adult Patient with Diabetes: Systematic Literature Review

Nurul Azizatunnisa; Amelia Kurniati; Dikha Ayu Kurnia

doi:10.37287/ijghr.v6iS6.5065

Nurul Azizatunnisa Universitas Indonesia
Amelia Kurniati Universitas Indonesia
Dikha Ayu Kurnia Universitas Indonesia

DOI: https://doi.org/10.37287/ijghr.v6iS6.5065

Keywords: diabetic nephropathy, physical factors, psychological factors

Abstract

Diabetes is a type of chronic disease that progresses over time and can lead to various complications, one of which is diabetic nephropathy. The prevalence of kidney disorders in individuals with diabetes at a productive age in Indonesia is 4%, but only 0.6% have been diagnosed. This systematic review provide information about many factors affecting diabetic nephropathy, both physical and psychological factors in adult patient with diabetes. This systematic literature review utilizes several databases, i.e EBSCO, Oxford Journal, ProQuest, PubMed, Sage Journal, Science Direct, and Springer Link which published in the past five years (2019-2024). We used PICO in literature searching process, i.e. diabetic nephropathy (population), self-care OR family support OR risk factor OR primary assessment OR early warning signs (intervention), standard care (comparison), diabetic nephropathy OR diabetic kidney disease OR glomerulosclerosis, diabetic (outcome). Articles were selected based on inclusion and exclusion criteria and are presented using the PRISMA diagram. There were 10 relevant articles were identified. The sample size in this study was 7.892 from many health care areas from primary health care, outpatient clinic, and emergency department. Diabetic patients in this study include prediabetes, type 1 diabetes, and type 2 diabetes, DM ESRD and asymptomatic severe hypertension that potential to suffer kidney disfunction. The physical factors of diabetic nephropathy were body mass index (BMI), duration of diabetes diagnosis, vital signs, laboratory examination and comorbidity. Psychological factors include family support, self-care, diabetes control and education, Quality of Life (QoL) or Well-Being Index. There were six physical factors and four psychological factors that could be predictors of diabetic nephropathy.

References

Ali, N. et al. (2023) ‘Clinical utility of routine investigations and risk factors of end-organ damage in asymptomatic severe hypertension’, Internal and Emergency Medicine, 18(7), pp. 2037–2043. Available at: https://doi.org/10.1007/s11739-023-03403-8.

Asghar, Shoaib et al. (2023) ‘Metabolic Syndrome in Type 2 Diabetes Mellitus Patients: Prevalence, Risk Factors, and Associated Microvascular Complications’, Cureus, 15(5). Available at: https://doi.org/10.7759/cureus.39076.

Bürgi, H. et al. (1976) ‘Changes of circulating thyroxine, triiodothyronine and reverse triiodothyronine after radiographic contrast agents’, Journal of Clinical Endocrinology and Metabolism, 43(6), pp. 1203–1210. Available at: https://doi.org/10.1210/jcem-43-6-1203.

Catrina, S.B. and Zheng, X. (2021) ‘Hypoxia and hypoxia-inducible factors in diabetes and its complications’, Diabetologia, 64(4), pp. 709–716. Available at: https://doi.org/10.1007/s00125-021-05380-z.

Gabriel, R. et al. (2020) ‘Early prevention of diabetes microvascular complications in people with hyperglycaemia in Europe. ePREDICE randomized trial. Study protocol, recruitment and selected baseline data’, PLoS ONE, 15(4), pp. 1–23. Available at: https://doi.org/10.1371/journal.pone.0231196.

Griva, K. et al. (2019) ‘The combined diabetes and renal control trial (C-DIRECT) - A feasibility randomised controlled trial to evaluate outcomes in multi-morbid patients with diabetes and on dialysis using a mixed methods approach’, BMC Nephrology, 20(1), pp. 1–16. Available at: https://doi.org/10.1186/s12882-018-1183-z.

Haroon, M. and Husnain, S.M. (2021) Diabetes and Endocrinology: Essentials of Clinical Practice. 1st edn, Momentum Press Health Education Collection. 1st edn. New York: Momentum Press, LLC.

JBI (2020) ‘Joanna Briggs Institute Checklist for Studies’.

Joshi, R. et al. (2023) ‘Prevalence and risk factors of chronic kidney disease among patients with type 2 diabetes mellitus at a tertiary care hospital in Nepal: a cross-sectional study’, BMJ Open, 13(2), pp. 1–8. Available at: https://doi.org/10.1136/bmjopen-2022-067238.

Kassa, R.N. et al. (2021) ‘Self-care practice and its predictors among adults with diabetes mellitus on follow up at public hospitals of Arsi zone, southeast Ethiopia’, BMC Research Notes, 14(1), pp. 1–7. Available at: https://doi.org/10.1186/s13104-021-05511-0.

Kementerian Kesehatan, B. (2023) Survei Kesehatan Indonesia Tahun 2023.

Kristianingrum, N.D., Wiarsih, W. and Nursasi, A.Y. (2018) ‘Perceived family support among older persons in diabetes mellitus self-management’, BMC Geriatrics, 18(Suppl 1), pp. 1–5. Available at: https://doi.org/10.1186/s12877-018-0981-2.

Laursen, J.C. et al. (2023) ‘Lower Blood Oxygen Saturation is Associated with Microvascular Complications in Individuals with Type 1 Diabetes’, Journal of Clinical Endocrinology and Metabolism, 108(1), pp. 99–106. Available at: https://doi.org/10.1210/clinem/dgac559.

Lopes, A.C. et al. (2023) ‘Clinical and Pharmacotherapeutic Profile of Patients with Type 2 Diabetes Mellitus Admitted to a Hospital Emergency Department’, Biomedicines, 11(2). Available at: https://doi.org/10.3390/biomedicines11020256.

De Maria, M. et al. (2022) ‘Further Evidence of Psychometric Performance of the Self-care of Diabetes Inventory in Adults with Type 1 and Type 2 Diabetes’, Annals of Behavioral Medicine, 56(6), pp. 632–644. Available at: https://doi.org/10.1093/abm/kaab088.

Mihardja, L. et al. (2018) ‘Prevalence of kidney dysfunction in diabetes mellitus and associated risk factors among productive age Indonesian’, Journal of Diabetes and Metabolic Disorders, 17(1), pp. 53–61. Available at: https://doi.org/10.1007/s40200-018-0338-6.

Okati-Aliabad, H. et al. (2024) ‘Determinants of diabetes self-care activities in patients with type 2 diabetes based on self-determination theory’, Acta Diabetologica, 61(3), pp. 297–307. Available at: https://doi.org/10.1007/s00592-023-02186-w.

Sari, Y. et al. (2021) ‘The differences in health-related quality of life between younger and older adults and its associated factors in patients with type 2 diabetes mellitus in Indonesia’, Health and Quality of Life Outcomes, 19(1), pp. 1–11. Available at: https://doi.org/10.1186/s12955-021-01756-2.

Singh, K. et al. (2024) ‘Rate and risk factors of kidney function decline among South Asians with type 2 diabetes: analysis of the CARRS Trial’, BMJ open diabetes research & care, 12(4). Available at: https://doi.org/10.1136/bmjdrc-2024-004218.

Skyler, J.S. et al. (2017) ‘Differentiation of diabetes by pathophysiology, natural history, and prognosis’, Diabetes, 66(2), pp. 241–255. Available at: https://doi.org/10.2337/db16-0806.

Slieker, R.C. et al. (2021) ‘Performance of prediction models for nephropathy in people with type 2 diabetes: Systematic review and external validation study’, The BMJ, 374, pp. 10–12. Available at: https://doi.org/10.1136/bmj.n2134.

Thongduang, K. et al. (2022) ‘The Influence of Family Caregiver Knowledge and Behavior on Elderly Diabetic Patients’ Quality of Life in Northern Thailand’, International Journal of Environmental Research and Public Health, 19(16). Available at: https://doi.org/10.3390/ijerph191610216.

Wang, C.P. et al. (2021) ‘Inter-relationship of risk factors and pathways associated with chronic kidney disease in patients with type 2 diabetes mellitus: a structural equation modelling analysis’, Public Health, 190(2021), pp. 135–144. Available at: https://doi.org/10.1016/j.puhe.2020.02.007.