Relationship of Malaria Parasite Density Level in Blood with Apgar Score of Newborn Babies
Abstract
Placental malaria is a serious health problem that must be treated immediately. WHO data records that 12 million pregnant women were infected with malaria throughout the world in 2019. Of the pregnant women infected with malaria, it was reported that 40% experienced placental malaria during childbirth. At the national level, it was found that the prevalence of malaria in pregnant women was 525 from the 2018 Basic Health Research results. At the provincial level, the largest contributor was Papua with a total of 2816 cases in 2020. Jayapura Regency was in 4th position with 402 cases of pregnancy malaria. Disturbances in newborn baby oxygenation caused by placental malaria are the main-focus to be resolved immediately so that efforts are made to investigate the level of relationship between the level of placental malaria parasitemia and clinical signs of impaired newborn baby oxygenation (APGAR Score) needs to be developed in order to create a formula for handling and preventing these impacts. Objective: Analyzing the relationship between the level of malaria parasite density in the blood of mothers giving birth and APGAR Score of newborn babies. Method: This research is descriptive correlational research. The total population was 36 mothers with a history of malaria during their pregnancy and research samples were taken with technique Total Sampling. Data were analyzed using a correlation test Rank Spearman with a significance level <0,05. Results: Based on correlation test Rank Spearman sig value is obtained. (2-tailed) as large as 0.00 <0.05 so that there is a significant relationship between the level of malaria parasite density in the blood of the mother giving birth with APGAR Score of newborn babies. The correlation coefficient value between the two variables is -0.658 which is included in the strong correlation category with a negative or inverse correlation direction. The higher the density of malaria parasites in the mother's blood, the lower the APGAR of newborn baby value. Conclusion: Most of the malaria parasite density levels in mothers who gave birth were in the negative category with an average APGAR score for birth defects of 8.47. There is a relationship between the level of density of malaria parasites in the blood of pregnant women and APGAR Score of newborn babies.
References
Aitken, E. H., & Rogerson, S. J. (2022). Placental Malaria Tackling Variants With Antibodies. Elife Insight, 10–12. https://doi.org/https:// doi. org/ 10. 7554/ eLife. 77751
Berry, I., Walker, P., Tagbor, H., & Al., E. (2018). Seasonal Dynamics of Malaria in Pregnancy in West Africa: Evidence for Carriage of Infections Acquired Before Pregnancy Until First Contact with Antenatal Care. Am J Trop Med Hyg, 98(2), 534–42.
Christine M; Cserti; Walter H; Dzik. (2017). ABO blood group system and Plasmodium falciparum malaria. Bloodjournal, 110(7), 2250–2258.
Conroy, A. L., Silver, K. L., Zhong, K., Rennie, M., Ward, P., Sarma, J. V., … Kain, K. C. (2013). Article Complement Activation and the Resulting Placental Vascular Insufficiency Drives Fetal Growth Restriction Associated with Placental Malaria. CHOM, 13(2), 215–226. https://doi.org/10.1016/j.chom.2013.01.010
Costa F, TM; Lopes S, CP; Ferrer M; Leite J, A; Jaular, L. M. B. M., Nogueira P, A; Mourao P, G; Becerra Fernandez, C; , RioLacerda M, V. A. M., & Nogeira; Gysin, J. (2016). Cytoadhesion of Plasmodium falciparum-Infected Erythrocytes and the Infected Placenta : a Two-Way Patway. Brazilian Journal of Medical and Biological Research, 39, 1525–1536.
Dinkes Kabupaten Jayapura. (2021). Situasi Malaria Kabupaten Jayapura, Papua Tahun 2021. Jayapura. Retrieved from linktr.ee/siagamalaria
Doritchamou, J. Y. A., Renn, J. P., Jenkins, B., Mahamar, A., Dicko, A., Fried, M., & Duffy, P. E. (2022). A single full- length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates, 1–16.
Ghosh A, Srinivasan P, Abraham EG, F. H. and J.-L. M. (2017). Molecular Strategies to Study Plasmodium-mosquito Interaction. Trends Parasitol, 19(2), 94–101.
Indrawati, R. R. R., Juffrie, M., Hakimi, M. S., & Wijayanti, M. (2018). Efek Malaria Maternal Terhadap Kerentanan Infeksi Malaria Pada Bayi Selama 1 Tahun Pertama Kehidupan. Gadjah Mada University. Retrieved from http://etd.repository.ugm.ac.id/home/detail_pencarian/155400
Kementerian Kesehatan RI. (2019). Laporan Nasional Riskesdas 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan. Retrieved from http://labdata.litbang.kemkes.go.id/images/download/laporan/RKD/2018/Laporan_Nasional_RKD2018_FINAL.pdf
Kementerian Kesehatan RI. (2021). Profil Kesehatan Indonesia Tahun 2020. Jakarta.
Lawford, H. L. S., Cc, A., Kumar, S., Liley, H. G., & Bora, S. (2019). International Journal of Infectious Diseases Establishing a conceptual framework of the impact of placental malaria on infant neurodevelopment. International Journal of Infectious Diseases, 84, 54–65. https://doi.org/10.1016/j.ijid.2019.04.019
Mabui, S. (2021). Strategi Perscepatan Penurunan Kasus Malaria Provinsi Papua. Jayapura.
Mens, P. F., Bojtor, E. C., & Schallig, H. D. F. H. (2019). European Journal of Obstetrics & Gynecology and Reproductive Biology Molecular interactions in the placenta during malaria infection. European Journal of Obstetrics and Gynecology, 152(2), 126–132. https://doi.org/10.1016/j.ejogrb.2010.05.013
Miller LH; Baruch DI; Marsh K; Doumbo OK. (2020). The Pathogenic Basis of Malaria Nature, 415(5), 673–679.
Tomlinson, A., & Semblat, J. (2021). VAR2CSA-Mediated Host Defense Evasion of Plasmodium falciparum Infected Erythrocytes in Placental Malaria. Frontiers In Immunology, 11(February), 1–10. https://doi.org/10.3389/fimmu.2020.624126
Vignali M; Speake C; Duffy PE. (2017). Malaria sporozoite proteome leaves a trail. Genome Biology, 10(216). https://doi.org/10.1186/gb-2017-10-4-216)
WHO. (2020). World Malaria Report 2019. Genesis of placental sequestration in malaria and pos‑ sible targets for drugs for placental malaria. Birth Defects Res. Clark RL, 111(10), 83–569. Retrieved from https://www.who.int/publi cations- detail/world- malaria- report- 2019
Zakama, A. K., Ozarslan, N., & Gaw, S. L. (2020). Placental Malaria, 162–171.
Copyright (c) 2024 Indonesian Journal of Global Health Research

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.



