Wound Healing Potency of Edible Bird’s Nest

Jessica Alysia; Maureen Miracle Stella; Maureen Widjaja; Lorettha Wijaya

doi:10.37287/ijghr.v7i1.4065

Jessica Alysia Universitas Katolik Indonesia Atma Jaya
Maureen Miracle Stella Universitas Katolik Indonesia Atma Jaya
Maureen Widjaja Universitas Katolik Indonesia Atma Jaya
Lorettha Wijaya Universitas Katolik Indonesia Atma Jaya

DOI: https://doi.org/10.37287/ijghr.v7i1.4065

Keywords: edible bird’s nest, scar, wound healing

Abstract

Edible bird's nest (EBN) or swiftlet's nest has recently been used extensively in regenerative medicine. This study aims to give a more thorough overview on the efficacy of EBN as a wound-healing agent. Method: We searched literature through several databases: Google Scholar, PubMed, Proquest, JSTOR, EBSCOhost, and SAGE. The keywords used were "bird nest, scar, wound healing" and their synonyms. The inclusion criteria were original articles written in English and assessed the effects of EBN in the wound healing process. We found 9 in vitro studies and 4 in vivo studies reporting wound healing effect of EBN, both macroscopically and microscopically. EBN could increase wound healing process through several mechanisms, such as cell proliferation, anti-oxidants, anti-inflammation, increased collagen synthesis, and tissue hydration. EBN has the potential to be used as a natural bioactive agent to increase the wound healing process.

References

Benjakul, S., & Chantakun, K. (2022). Sustainability challenges in edible bird’s nest: Full exploitation and health benefit. In Future Foods (pp. 315–330). Elsevier. https://doi.org/10.1016/B978-0-323-91001-9.00029-3

Brinkløv, S., Fenton, M. B., & Ratcliffe, J. M. (2013). Echolocation in Oilbirds and swiftlets. Frontiers in Physiology, 4. https://doi.org/10.3389/fphys.2013.00123

Cruelty Served in a Dish | Sunday Observer. (2017). Https://Www.Sundayobserver.Lk/2017/11/05/Features/Cruelty-Served-Dish.

Fadhilah, Z. A., Suhana, M. R. E., Chua, K. H., & Norzana, A. G. (2013). Edible Bird’s Nest Extract Potentiates the Closure of Corneal Epithelial Defect. The Open Conference Proceedings Journal, 4(1), 83–83. https://doi.org/10.2174/2210289201304010083

Hun, L. T., Wani, W. A., Tjih, E. T. T., Adnan, N. A., Le Ling, Y., & Aziz, R. A. (2015). Investigations into the Physicochemical, Biochemical and Antibacterial Properties of Edible Bird’s Nest. Journal of Chemical and Pharmaceutical Research, 7(7), 228–247.

Hwang, E., Park, S. W., & Yang, J.-E. (2020). Anti-aging, anti-inflammatory, and wound-healing activities of edible bird’s nest in human skin keratinocytes and fibroblasts Articles. Pharmacognosy Magazine, 16(69), 336–342.

Jumat, M. A., Hamzah, M. S. A., Mohd Daud, N., & Saidin, S. (2022). Evaluation on the Antibacterial Activity and Biocompatibility Natural Soap Formulated with Edible Bird Nest. Journal of Medical Device Technology, 1(1), 1–3. https://doi.org/10.11113/jmeditec.v1n1.7

Karimi, K., Odhav, A., Kollipara, R., Fike, J., Stanford, C., & Hall, J. C. (2017). Acute Cutaneous Necrosis: A Guide to Early Diagnosis and Treatment. Journal of Cutaneous Medicine and Surgery, 21(5), 425–437. https://doi.org/10.1177/1203475417708164

Lai, Q. W. S., Guo, M. S. S., Wu, K. Q., Liao, Z., Guan, D., Dong, T. T., Tong, P., & Tsim, K. W. K. (2021). Edible Bird’s Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.685982

Lee, T. H., Wani, W. A., Lee, C. H., Cheng, K. K., Shreaz, S., Wong, S., Hamdan, N., & Azmi, N. A. (2021). Edible Bird’s Nest: The Functional Values of the Prized Animal-Based Bioproduct From Southeast Asia–A Review. Frontiers in Pharmacology, 12. https://doi.org/10.3389/fphar.2021.626233

Looi, Q. H., Amin, H., Aini, I., Zuki, M., & Omar, A. R. (2017). De novo transcriptome analysis shows differential expression of genes in salivary glands of edible bird’s nest producing swiftlets. BMC Genomics, 18(1), 504. https://doi.org/10.1186/s12864-017-3861-9

Ma, F., & Liu, D. (2012). Sketch of the edible bird’s nest and its important bioactivities. Food Research International, 48(2), 559–567. https://doi.org/10.1016/j.foodres.2012.06.001

Marcone, M. F. (2005). Characterization of the edible bird’s nest the “Caviar of the East”. Food Research International, 38(10), 1125–1134. https://doi.org/10.1016/j.foodres.2005.02.008

Masuda, S., Makioka-Itaya, Y., Ijichi, T., & Tsukahara, T. (2022). Edible bird’s nest extract downregulates epidermal apoptosis and helps reduce damage by ultraviolet radiation in skin of hairless mice. Journal of Clinical Biochemistry and Nutrition, 70(1), 21–54. https://doi.org/10.3164/jcbn.21-54

Matsukawa, N., Matsumoto, M., Bukawa, W., Chiji, H., Nakayama, K., Hara, H., & Tsukahara, T. (2011). Improvement of Bone Strength and Dermal Thickness Due to Dietary Edible Bird’s Nest Extract in Ovariectomized Rats. Bioscience, Biotechnology, and Biochemistry, 75(3), 590–592. https://doi.org/10.1271/bbb.100705

Napavichayanun, Supamas, Yamdech, R., Reddy, N., & Aramwit, P. (2021). Edible Aerodramus fuciphagus bird nest for wound healing: In search of the best extraction method to increase sialic acid and its relationship with collagen production. Agriculture and Natural Resources, Volume 55 issue 2. https://doi.org/10.34044/j.anres.2021.55.2.19

Norhayati, M. K., Azman, O., & Wan Nazaimoon, W. (2010). Preliminary Study of the Nutritional Content of Malaysian Edible Bird’s Nest. Malaysian Journal of Nutrition, 16(3), 389–396.

Ofiwijayanti, H., Hidayat, S. T., & Khafidhoh, N. (2017). BIRD’S NEST EXTRACT CREAM: TREATMENT FOR PERINEAL WOUND IN RATTUS NORVEGICUS. Belitung Nursing Journal, 3(3), 265–271. https://doi.org/10.33546/bnj.100

Park, J., Hwang, S., & Yoon, I.-S. (2017). Advanced Growth Factor Delivery Systems in Wound Management and Skin Regeneration. Molecules, 22(8), 1259. https://doi.org/10.3390/molecules22081259

Qi Hao, L., & Abdul Rahman, O. (2016). Swiftlets and Edible Bird’s Nest Industry in Asia . Pertanika Journal of Scholarly Research Reviews , 2(1), 32–48.

Roh, K.-B., Lee, J., Kim, Y.-S., Park, J., Kim, J.-H., Lee, J., & Park, D. (2012). Mechanisms of Edible Bird’s Nest Extract-Induced Proliferation of Human Adipose-Derived Stem Cells. Evidence-Based Complementary and Alternative Medicine, 2012, 1–11. https://doi.org/10.1155/2012/797520

Sandi, D. A. D., & Musfirah, Y. (2019). Wound Healing Effects of Edible Bird’s Nests Oinment (Aerodramus fuciphagus) in Alloxan-Induced Male Rats. Majalah Obat Tradisional, 24(1), 33. https://doi.org/10.22146/mot.39072

Schauer, R., & Kamerling, J. P. (2018). Exploration of the Sialic Acid World. In Adv Carbohydr Chem Biochem. (pp. 1–213). https://doi.org/10.1016/bs.accb.2018.09.001

Terazawa, S., & Hiroshi Shimoda, H. (2020). Keratinocyte Proliferative and Wound Healing Effects of Edible Bird’s Nest Extract on Human Skin. International Journal of Biomedical Science, 16(4).

Tung, C.-H., Pan, J.-Q., Chang, H.-M., & Chou, S.-S. (2020). Authentic determination of bird’s nests by saccharides profile. Journal of Food and Drug Analysis, 16(4). https://doi.org/10.38212/2224-6614.2339

Vimala, B., Hussain, H., & Nazaimoon, W. M. W. (2012). Effects of edible bird’s nest on tumour necrosis factor-alpha secretion, nitric oxide production and cell viability of lipopolysaccharide-stimulated RAW 264.7 macrophages. Food and Agricultural Immunology, 23(4), 303–314. https://doi.org/10.1080/09540105.2011.625494

Wallace, H. A., Basehore, B. M., & Zito, P. M. (2024). Wound Healing Phases.

Wong, Z. C. F., Chan, G. K. L., Wu, L., Lam, H. H. N., Yao, P., Dong, T. T. X., & Tsim, K. W. K. (2018). A comprehensive proteomics study on edible bird’s nest using new monoclonal antibody approach and application in quality control. Journal of Food Composition and Analysis, 66, 145–151. https://doi.org/10.1016/j.jfca.2017.12.014

Zainal Abidin, F., Hui, C. K., Luan, N. S., Mohd Ramli, E. S., Hun, L. T., & Abd Ghafar, N. (2011). Effects of edible bird’s nest (EBN) on cultured rabbit corneal keratocytes. BMC Complementary and Alternative Medicine, 11(1), 94. https://doi.org/10.1186/1472-6882-11-94

Zuki, A. B. Z., Abdul Ghani, M. M., Khadim, K. K., Intan-Shameha, A. R. , & Kamaruddin, M. I. (2012). Anatomical structures of the limb of white-nest swiftlet (Aerodramus fuciphagus) and white-headed munia (Lonchura maja). Pertanika Journal of Tropical Agricultural Science, 35(3), 613–622.