The Association between Maternal Adverse Childhood Experiences and Substances Abuse: A Systematic Review

  • Nadya Puspita Adriana Universitas Pembangunan Jaya
Keywords: adverse childhood experiences, maternal, pregnant women, substance abuse


An increasing number of studies are identifying associations between adverse childhood experiences (ACEs) and substances abuse. We aimed to review the association between  multiple types of ACE with different kind of substance abuse among pregnant women. This research aims to determine the relationship between mother children's problems experiences and substance use. Method: We looked through the databases at ProQuest, PubMed, and Science Direct databases were utilized by the authors to do an extensive and methodical search of the English-language literature for studies on adverse childhood events that were published until January 31, 2024. The search phrases used are “adverse childhood experiences”, “maternal”, and “substances abuse”.Results: Most of the article were cohort studies conducted in the USA. All studies assessed ACEs retrospectively. The main conclusions of the studies were that there is a  a positive association between ACEs with the development and severity of substance use disorder among pregnant women.  Conclusions: We found that adverse childhood experiences exposure can result in different kind of substances abuse among pregnant women compared with those without adverse childhood experiences.


Afifi, T. O., Taillieu, T., Salmon, S., Davila, I. G., Stewart-Tufescu, A., Fortier, J., Struck, S., Asmundson, G. J. G., Sareen, J., & MacMillan, H. L. (2020). Adverse childhood experiences (ACEs), peer victimization, and substance use among adolescents. Child Abuse & Neglect, 106, 104504.

Anda, R. F., Croft, J. B., Felitti, V. J., Nordenberg, D., Giles, W. H., Williamson, D. F., & Giovino, G. A. (1999). Adverse childhood experiences and smoking during adolescence and adulthood. JAMA, 282(17), 1652–1658.

Antoniou, G., Lambourg, E., Steele, J. D., & Colvin, L. A. (2023). The effect of adverse childhood experiences on chronic pain and major depression in adulthood: a systematic review and meta-analysis. British Journal of Anaesthesia, 130(6), 729–746.

Björkenstam, C., Kosidou, K., & Björkenstam, E. (2017). Childhood adversity and risk of suicide: cohort study of 548 721 adolescents and young adults in Sweden. BMJ (Clinical Research Ed.), 357, j1334.

Bruskas, D., & Tessin, D. H. (2013). Adverse childhood experiences and psychosocial well-being of women who were in foster care as children. The Permanente Journal, 17(3), e131-41.

Burns, E., Jackson, J., & Harding, H. (2010). Child Maltreatment, Emotion Regulation, and Posttraumatic Stress: The Impact of Emotional Abuse. Journal of Aggression Maltreatment & Trauma, 19, 801–819.

Canfield, M., Radcliffe, P., Marlow, S., Boreham, M., & Gilchrist, G. (2017). Maternal substance use and child protection: a rapid evidence assessment of factors associated with loss of child care. Child Abuse & Neglect, 70, 11–27.

Chung, E. K., Nurmohamed, L., Mathew, L., Elo, I. T., Coyne, J. C., & Culhane, J. F. (2010). Risky health behaviors among mothers-to-be: the impact of adverse childhood experiences. Academic Pediatrics, 10(4), 245–251.

Cicchetti, D., & Rogosch, F. A. (2009). Adaptive coping under conditions of extreme stress: Multilevel influences on the determinants of resilience in maltreated children. New Directions for Child and Adolescent Development, 2009(124), 47–59.

Cronholm, P. F., Forke, C. M., Wade, R., Bair-Merritt, M. H., Davis, M., Harkins-Schwarz, M., Pachter, L. M., & Fein, J. A. (2015). Adverse Childhood Experiences: Expanding the Concept of Adversity. American Journal of Preventive Medicine, 49(3), 354–361.

Currie, C. L., & Tough, S. C. (2021). Adverse childhood experiences are associated with illicit drug use among pregnant women with middle to high socioeconomic status: findings from the All Our Families Cohort. BMC Pregnancy and Childbirth, 21(1), 133.

Dube, S. R., Felitti, V. J., Dong, M., Chapman, D. P., Giles, W. H., & Anda, R. F. (2003). Childhood abuse, neglect, and household dysfunction and the risk of illicit drug use: the adverse childhood experiences study. Pediatrics, 111(3), 564–572.

Dube, S. R., Miller, J. W., Brown, D. W., Giles, W. H., Felitti, V. J., Dong, M., & Anda, R. F. (2006). Adverse childhood experiences and the association with ever using alcohol and initiating alcohol use during adolescence. The Journal of Adolescent Health : Official Publication of the Society for Adolescent Medicine, 38(4), 444.e1-10.

Duka, S., Rahman, S., Hansen, S. E., & Esernio-Jenssen, D. (2023). The Effect of Maternal Adverse Childhood Experiences (ACEs) on Substance Use During Pregnancy. Maternal and Child Health Journal, 27(Suppl 1), 153–165.

Felitti, V. J., Anda, R. F., Nordenberg, D., Williamson, D. F., Spitz, A. M., Edwards, V., Koss, M. P., & Marks, J. S. (1998). Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American Journal of Preventive Medicine, 14(4), 245–258.

Foti, T. R., Watson, C., Adams, S. R., Rios, N., Staunton, M., Wei, J., Sterling, S. A., Ridout, K. K., & Young-Wolff, K. C. (2023). Associations between Adverse Childhood Experiences (ACEs) and Prenatal Mental Health and Substance Use. International Journal of Environmental Research and Public Health, 20(13).

Fraiberg, S., Adelson, E., & Shapiro, V. (1975). Ghosts in the Nursery: A Psychoanalytic Approach to the Problems of Impaired Infant-Mother Relationships. Journal of the American Academy of Child Psychiatry, 14(3), 387–421.

Frankenberger, D. J., Clements-Nolle, K., & Yang, W. (2015). The Association between Adverse Childhood Experiences and Alcohol Use during Pregnancy in a Representative Sample of Adult Women. Women’s Health Issues : Official Publication of the Jacobs Institute of Women’s Health, 25(6), 688–695.

Freimann, T., Coggon, D., Merisalu, E., Animägi, L., & Pääsuke, M. (2013). Risk factors for musculoskeletal pain amongst nurses in Estonia: a cross-sectional study. BMC Musculoskeletal Disorders, 14, 334.

Goodman, M. L., Grouls, A., Chen, C. X., Keiser, P. H., & Gitari, S. (2017). Adverse Childhood Experiences Predict Alcohol Consumption Patterns Among Kenyan Mothers. Substance Use & Misuse, 52(5), 632–638.

Håkansson, U., Watten, R., Söderström, K., Skårderud, F., & Øie, M. G. (2018). Adverse and adaptive childhood experiences are associated with parental reflective functioning in mothers with substance use disorder. Child Abuse & Neglect, 81, 259–273.

Hemady, C. L., Speyer, L. G., Murray, A. L., Brown, R. H., Meinck, F., Fry, D., Do, H., Sikander, S., Madrid, B., Fernando, A., Walker, S., Dunne, M., Foley, S., Hughes, C., Osafo, J., Baban, A., Taut, D., Ward, C. L., Van Thang, V., … Eisner, M. (2022). Patterns of adverse childhood experiences and associations with prenatal substance use and poor infant outcomes in a multi-country cohort of mothers: a latent class analysis. BMC Pregnancy and Childbirth, 22(1), 505.

Hillis, S., Mercy, J., Amobi, A., & Kress, H. (2016). Global Prevalence of Past-year Violence Against Children: A Systematic Review and Minimum Estimates. Pediatrics, 137(3), e20154079.

Hughes, K., Bellis, M. A., Hardcastle, K. A., Sethi, D., Butchart, A., Mikton, C., Jones, L., & Dunne, M. P. (2017). The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis. The Lancet. Public Health, 2(8), e356–e366.

Jacobs, Benjamin; Ganson, Kyle; Jackson, Dylan; Nagata, Jason; Testa, Alexander; Zhang, L. (2023). Maternal Adverse Childhood Experiences (ACEs) Increase Opioid Use During Pregnancy. Obstetrics & Gynecology, 141(178S-78S).

Jasthi, D. L., Nagle-Yang, S., Frank, S., Masotya, M., & Huth-Bocks, A. (2022). Associations Between Adverse Childhood Experiences and Prenatal Mental Health and Substance Use Among Urban, Low-Income Women. Community Mental Health Journal, 58(3), 595–605.

Lee, K., Lam, S. K. K., Hung, S. L., & Fung, H. W. (2023). Substance abuse among mothers in Taiwan: Investigating its prevalence and testing the trauma model. Asian Journal of Psychiatry, 90, 103805.

Lee, W.-C., Fang, S.-C., Chen, Y.-Y., Liu, H.-C., Huang, M.-C., & McKetin, R. (2021). Exploring the mediating role of methamphetamine use in the relationship between adverse childhood experiences and attempted suicide. Addictive Behaviors, 123, 107060.

Leeners, B., Rath, W., Block, E., Görres, G., & Tschudin, S. (2014). Risk factors for unfavorable pregnancy outcome in women with adverse childhood experiences. Journal of Perinatal Medicine, 42(2), 171–178.

Leza, L., Siria, S., López-Goñi, J. J., & Fernández-Montalvo, J. (2021). Adverse childhood experiences (ACEs) and substance use disorder (SUD): A scoping review. Drug and Alcohol Dependence, 221, 108563.

Lieberman, A. F., Chu, A., Van Horn, P., & Harris, W. W. (2011). Trauma in early childhood: empirical evidence and clinical implications. Development and Psychopathology, 23(2), 397–410.

Madigan, S., Wade, M., Plamondon, A., & Jenkins, J. M. (2016). Neighborhood Collective Efficacy Moderates the Association between Maternal Adverse Childhood Experiences and Marital Conflict. American Journal of Community Psychology, 57(3–4), 437–447.

Racine, N., McDonald, S., Chaput, K., Tough, S., & Madigan, S. (2020). Maternal substance use in pregnancy: Differential prediction by childhood adversity subtypes. Preventive Medicine, 141(May), 106303.

Racine, N., McDonald, S., Chaput, K., Tough, S., & Madigan, S. (2021). Pathways from Maternal Adverse Childhood Experiences to Substance Use in Pregnancy: Findings from the All Our Families Cohort. Journal of Women’s Health (2002), 30(12), 1795–1803.

Rod, N. H., Bengtsson, J., Budtz-Jørgensen, E., Clipet-Jensen, C., Taylor-Robinson, D., Andersen, A.-M. N., Dich, N., & Rieckmann, A. (2020). Trajectories of childhood adversity and mortality in early adulthood: a population-based cohort study. Lancet (London, England), 396(10249), 489–497.

Testa, A., Jackson, D. B., Boccio, C., Ganson, K. T., & Nagata, J. M. (2022). Adverse childhood experiences and marijuana use during pregnancy: Findings from the North Dakota and South Dakota PRAMS, 2017-2019. Drug and Alcohol Dependence, 230, 109197.

Thomas, S. A., Clements-Nolle, K. D., Wagner, K. D., Omaye, S., Lu, M., & Yang, W. (2023). Adverse childhood experiences, antenatal stressful life events, and marijuana use during pregnancy: A population-based study. Preventive Medicine, 174, 107656.

WHO. (2016). WHO Global plan of action to strengthen the role of the health system within a national multisectoral response to address interpersonal violence, in particular against women and girls, and against children.

How to Cite
Adriana, N. P. (2024). The Association between Maternal Adverse Childhood Experiences and Substances Abuse: A Systematic Review. Indonesian Journal of Global Health Research, 6(3), 1173-1186.