Penurunan Kadar Gula Darah Menggunakan Daun Kemangi

  • Kadek Erwin Wijaya Fakultas Kedokteran, Universitas Lampung
  • Abiyyi Pratama Husada Widoyoko Fakultas Kedokteran, Universitas Lampung
Keywords: daun kemangi, diabetes, eugenol, asam ursolat

Abstract

Diabetes di Indonesia dianggap sebagai masalah kesehatan utama dan telah menjadi perhatian sejak awal 1980-an. Diabetes adalah salah satu penyebab utama kematian di indonesia. Indonesia dinilai sebagai salah satu dari sepuluh negara teratas secara global dengan jumlah individu pengidap diabetes yang tinggi pada tahun 2013. Diperkirakan bahwa pola yang sama akan berlanjut kecuali intervensi untuk mencegah dan mengelola diabetes diterapkan. Metode yang digunakan pada penelitian ini adalah studi literature review. Sumber pustaka yang digunakan dalam penyusunan melibatkan 19 pustaka yang berasal dari 2 buku dan 17 jurnal internasional. Tahun penerbitan sumber pustaka yang digunakan dalam penulisan artikel adalah dari tahun 2010 sampai tahun 2018. Berbagai penelitian menunjukkan hasil yang cukup signifikan mengenai pengaruh daun kemangi terhadap penurunan kadar gula darah. Ergunol pada daun kemangi memiliki beberapa mekanisme sebagai antidiabetik seperti inhibisi aktivitas dari α-glucosidases, Inhibisi dari formasi AGE, mencegah perlekatan glukosa terhadap serum albumin dan meningkatkan konsentrasi dari enzim antioksidan. Asam ursolat dalam daun kemangi menstimulasi pengambilan glukosa melalui berbagai cara.

 Kata Kunci: daun kemangi, diabetes, eugenol, asam ursolat

 DECREASED BLOOD SUGAR LEVELS USING TULSI LEAVES

                                                                                        ABSTRACT

Diabetes in Indonesia is considered a major health problem and has been a concern since the early 1980s. Diabetes is one of the leading causes of death in Indonesia. Indonesia is rated as one of the top ten countries globally with a high number of individuals with diabetes in 2013. It is estimated that the same pattern will continue unless interventions to prevent and manage diabetes are implemented. The method used in this study is a literature review. Literature sources used in the preparation involved 18 libraries originating from books, national journals and international journals. The year of publication of library sources used in article writing is from 2010 to 2018. Various studies have shown significant results regarding the effect of tulsi leaves on reducing blood sugar levels. Eugenol on basil leaves has several antidiabetic mechanisms such as inhibitory activity of α-glucosidases, inhibition of AGE formation, prevent glucose attachment to serum albumin and increase concentration of antioxidant enzymes. Ursolic acid in tulsi leaves stimulates glucose uptake in various ways.

 Keyword: tulsi, diabetes, eugenol, ursolic acid

References

American Diabetic Association. 2019. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2019. Diabetes Care. 42 (1), 1 – 16.

Antora, RA. dan Salleh, RM. 2017. Antihyperglycemic Effect of Ocimum Plants: A Short Review. Asian Paciffic Journal of Tropical Biomedicine. 1691 (17), 30773 – 6.

Abhilash, RS. Vijay, Y. Deepthi, T. Sri, LC. Vibha, R. Swetha, R. et al. 2013. Anti-Diabetic Effect of Ethanol Extract of Leaves of Ocimum sanctum in Alloxan Induced Diabetes in Rats. International Journal of Basic & Clinical Pharmacology. 2 (5), 613 – 6.

Al-Trad, B. Alkhaeeb, H. Alsmadi, W. Al-Zoubi, M. 2018. Eugenol Ameliorates Insulin Resistance, Oxidative Stress and Inflammation in High Fat Diet/Streptozotocin-Induced Diabetic Rat. Life Sciences.

Castro, AJG. Frederico, MJS. Cazarolli, LH. Mendes, CP. Bretanha, LC. Schmidts, EC. Bauzon, ZL. et al. 2014. The Mechanism of Action of Ursolic Acid as Insulin Secretagogue and Insulinomimetic is Mediated by Cross-Talk Between Calcium and Kinases to Regulate Glucose Balance. El Sevier. 51 – 61.

George, K. dan Alberti, MM. 2010. The Classification and Diagnosis of Diabetes Mellitus. Dalam: Hold, RIG. Cockram, CS. Flyvbjerg, A. Goldstein, BJ. Textbook of Diabetes. Edisi ke-4. Oxford : Wiley-Blackwell.

Joshi, RK. 2017. Phytoconstituents, Traditional, Medical and Bioactive Uses of Tulsi (Ocimum sanctum Linn.): A Review. Journal of Pharmacognosy and Phytochemistry. 6 (2), 261 – 4.

Khalil, AA. Rahman, UU. Khan, MR. Sahar, A. Mehmood, T. Khan, M. 2017. Essenntial Oil Eugenol: Sources, Extraction Techniques and Nutraceutical Perspectives. Royal Society of Chemistry. 7, 32669 – 81.

Ligita, T. Wicking, K. Francis, K. Harvey, N. Nurjannah, I. 2019. How People Living with Diabetes in Indonesia Learn About Their Disease: A Grounded Theory Study. PLoS ONE. 14 (2).

Lotfy, M. Adeghate, J. Singh, J. Adeghate, E. (2017). Chronic Complication of Diabetes Mellitus: A Mini Review. Bentham Science Publisher. 13 (1), 1 – 9.

Mnafgui, K. Kaanich, F. Derbali, A. Hamden, K. Derbali, F. Slama, S. Allouche, N. Elfeki, A. (2013). Inhibition of Key Enzymes Related to Diabetes and Hypertension by Eugenol in vitro and in Alloxan-induced Diabetic Rats. Archives of Physiology and Biochemistry.

Nim DK, Shankar P, Chaurasia R, Goel B, Dixit RK. (2013). Clinical Evaluation of Antihyperglycemic Activity of Ocimum sanctum in Comparison with Glibenclamide in The Rat Model of T2. International J Pharm Bio Sci. 4(2): 699-70.

Raja, TA. Reddy, RR. Priyadharshini, MB. (2016). An Evaluation of Anti-hyperglycemic Activity of Ocimum sanctum Linn (Leaves) in Wister Rats. Pharm Innov J. 5 (1): 1-3.

Ramkissoon, J.S. Mahomoodally, FM. Ahmed, N. Subratty, HA. (2012). Natural Inhibitors of Advanced Glycation End-Products. Nutrition & Food Science. 42 (6), 397 – 404.

Somasundaram, G. Manimekalai, K. Salwe, KJ. Pandiamunian. (2012). Evaluation of The Antidiabetic Effect of Ocimum sanctum in Type 2 Diabetic Patients. International Journal of Life Science & Pharma Reseacrh. 2 (3), 1 – 7.

Utsav. Kumar, B. Kumar, A. (2016). Diabetes Mellitus and its Control by Ocimum sanctum Extract in Mice Diabetic Model. Original Research Article. 5 (11), 795 – 810.

Verma, S. Gupta, M. Popil, H. Aggarwal, G. (2018). Diabetes Mellitus Treatment Using Herbal Drugs. International Journal of Phytomedicine. 10 (1), 1 – 10.

WHO. 2019. Classification of Diabetes Mellitus (2019). Geneva: WHO.

Yin, Z. Zhang, W. Feng, F. Zhang, Y. Kang, W. (2014). α-Glucosidase Inhibitors Isolated From Medicinal Plants. El Sevier. 3, 136 – 74.

Published
2020-01-06
How to Cite
Wijaya, K., & Widoyoko, A. (2020). Penurunan Kadar Gula Darah Menggunakan Daun Kemangi. Jurnal Penelitian Perawat Profesional, 2(1), 7-14. https://doi.org/10.37287/jppp.v2i1.37