Kesesuaian Hasil Laboratorium dengan Klinis Bayi Sepsis Neonatorum
Abstract
Sepsis merupakan respons sistemik pejamu terhadap infeksi, saat patogen atau toksin dilepaskan ke dalam sirkulasi darah sehingga terjadi aktivasi proses inflamasi. Tujuan penelitian ini adalah menggambarkan parameter hematologi dan manifestasi klinis pada sepsis neonatorum. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross-sectional. Populasi pada penelitian ini adalah semua bayi bayu lahir dengan sempel yaitu bayi baru lahir dengan sepsis neonatorum di Rumah Sakit Abdul Moeloek Provinsi Lampung dari bulan Mei 2022 – Mei 2023. Teknik pengambilan sampel menggunakan accidental sampling sebanyak 30 bayi. Alat pengumpul data berupa lembar rekam medik. Analisis data menggunakan persentase dari masing-masing variabel. Hasil penelitian terdapat kesesuaian antara hasil laboratorium dengan indicator sepsis neonatorum pada kultur positif sebagian besar adalah bayi kurang dari satu minggu, berjenis kelamin laki-laki, kadar hemoglobin rendah, kadar hematocrit rendah, leukosit normal, trombosit rendah dan tinggi, suhu tinggi dan pernafasan normal.
References
An, H., Zheng, W., Zhu, Q., & Chai, Y. (2022). A retrospective study of risk factors for early-onset neonatal sepsis with intrapartum maternal fever. PeerJ, 10. https://doi.org/10.7717/peerj.13834
Belachew, A., & Tewabe, T. (2020). Neonatal sepsis and its association with birth weight and gestational age among admitted neonates in Ethiopia: Systematic review and meta-analysis. BMC Pediatrics, 20(1). https://doi.org/10.1186/s12887-020-1949-x
Bhandari, V. (2014). Effective biomarkers for diagnosis of neonatal sepsis. Journal of the Pediatric Infectious Diseases Society, 3(3). https://doi.org/10.1093/jpids/piu063
Boskabadi, H., & Zakerihamidi, M. (2018). Evaluate the diagnosis of neonatal sepsis by measuring interleukins: A systematic review. In Pediatrics and Neonatology (Vol. 59, Issue 4). https://doi.org/10.1016/j.pedneo.2017.10.004
Celik, I. H., Hanna, M., Canpolat, F. E., & Mohan Pammi. (2022). Diagnosis of neonatal sepsis: the past, present and future. In Pediatric Research (Vol. 91, Issue 2). https://doi.org/10.1038/s41390-021-01696-z
Eichberger, J., Resch, E., & Resch, B. (2022). Diagnosis of Neonatal Sepsis: The Role of Inflammatory Markers. In Frontiers in Pediatrics (Vol. 10). https://doi.org/10.3389/fped.2022.840288
Elsayed, M., Hassan, A., Hashim, A., & Kasem, Y. (2021). The role of Hematological Scoring System (HSS) in early diagnosis of Neonatal Sepsis. Annals of Neonatology Journal, 3(1). https://doi.org/10.21608/anj.2021.140120
Gialamprinou, D., Mitsiakos, G., Katsaras, G. N., Kontovazainitis, C. G., Karagianni, P., Roilides, E., & Kenet, G. (2022). Neonatal Sepsis and Hemostasis. In Diagnostics (Vol. 12, Issue 2). https://doi.org/10.3390/diagnostics12020261
Golding, C. N., Schaltz-Buchholzer, F., Sanca, L., Clipet-Jensen, C., Benn, C. S., Au, N., Chipperfield, K., Kollmann, T. R., & Amenyogbe, N. A. (2020). Feasibility of manual white blood cell counts as a predictor of neonatal sepsis in a low-resource setting. Transactions of the Royal Society of Tropical Medicine and Hygiene, 114(8). https://doi.org/10.1093/trstmh/traa023
Hadinegoro, S. R. S., Chairulfatah, A., Latief, A., H.Pudjiadi, A., Malisie, R. F., & Alam, A. (2016). Diagnosis dan tatalaksana sepsis pada anak. Pedoman Nasional Pelayanan Kedokteran Ikatan Dokter Anak Indonesia, 1–47.
Hisamuddin, E., Hisam, A., Wahid, S., & Raza, G. (2015). Validity of c-reactive protein (CRP) for diagnosis of neonatal sepsis. Pakistan Journal of Medical Sciences, 31(3). https://doi.org/10.12669/pjms.313.6668
Iskandar, A., Arthamin, M. Z., Indriana, K., Anshory, M., Hur, M., & Di Somma, S. (2019). Comparison between presepsin and procalcitonin in early diagnosis of neonatal sepsis. Journal of Maternal-Fetal and Neonatal Medicine, 32(23). https://doi.org/10.1080/14767058.2018.1475643
İstanbullu, K., Köksal, N., Çetinkaya, M., Özkan, H., Yakut, T., Karkucak, M., & Doğan, H. (2019). The potential utility of real-time PCR of the 16s-rRNA gene in the diagnosis of neonatal sepsis. Turkish Journal of Pediatrics, 61(4). https://doi.org/10.24953/turkjped.2019.04.004
Karmila, A., Barchia, I., Ramandati, A., & Zhang, L. (2022). Clinical and bacteriological profile of culture-negative and culture-proven neonatal sepsis in Palembang, Indonesia. Journal of Infection in Developing Countries, 16(12). https://doi.org/10.3855/jidc.14638
Khan, F. (2019). C-reactive protein as a screening biomarker in neonatal sepsis. Journal of the College of Physicians and Surgeons Pakistan, 29(10). https://doi.org/10.29271/jcpsp.2019.10.951
Lakhey, A., & Shakya, H. (2017). Role of Sepsis Screening in early diagnosis of Neonatal Sepsis. Journal of Pathology of Nepal, 7(1). https://doi.org/10.3126/jpn.v7i1.16944
Morad, E. A., Rabie, R. A., Almalky, M. A., & Gebriel, M. G. (2020). Evaluation of Procalcitonin, C-Reactive Protein, and Interleukin-6 as Early Markers for Diagnosis of Neonatal Sepsis. International Journal of Microbiology, 2020. https://doi.org/10.1155/2020/8889086
Pillay, D., Naidoo, L., Swe Swe-Han, K., & Mahabeer, Y. (2021). Neonatal sepsis in a tertiary unit in South Africa. BMC Infectious Diseases, 21(1). https://doi.org/10.1186/s12879-021-05869-3
Popescu, C. R., Cavanagh, M. M. M., Tembo, B., Chiume, M., Lufesi, N., Goldfarb, D. M., Kissoon, N., & Lavoie, P. M. (2020). Neonatal sepsis in low-income countries: epidemiology, diagnosis and prevention. In Expert Review of Anti-Infective Therapy (Vol. 18, Issue 5). https://doi.org/10.1080/14787210.2020.1732818
Procianoy, R. S., & Silveira, R. C. (2020). The challenges of neonatal sepsis management. In Jornal de Pediatria (Vol. 96). https://doi.org/10.1016/j.jped.2019.10.004
Sahu, P., Raj Stanly, E. A., Simon Lewis, L. E., Prabhu, K., Rao, M., & Kunhikatta, V. (2022). Prediction modelling in the early detection of neonatal sepsis. In World Journal of Pediatrics (Vol. 18, Issue 3). https://doi.org/10.1007/s12519-021-00505-1
Sharma, D., Farahbakhsh, N., Shastri, S., & Sharma, P. (2018). Biomarkers for diagnosis of neonatal sepsis: a literature review. In Journal of Maternal-Fetal and Neonatal Medicine (Vol. 31, Issue 12). https://doi.org/10.1080/14767058.2017.1322060
Siahaan, A. E., Silaen, J. C., & Simanjuntak, L. (2021). Gambaran Profil Hematologi Dalam 24 Jam Pertama Pada Pasien Sepsis Di Unit Neonatus RSUD Dr. Pirngadi Medan Tahun 2017-2018. Nommensen Journal of Medicine, 6(2). https://doi.org/10.36655/njm.v6i2.243
Sorsa, A. (2018). Diagnostic Significance of White Blood Cell Count and C-Reactive Protein in Neonatal Sepsis; Asella Referral Hospital, South East Ethiopia. The Open Microbiology Journal, 12(1). https://doi.org/10.2174/1874285801812010209
Sweeney, T. E., Wynn, J. L., Cernada, M., Serna, E., Wong, H. R., Baker, H. V., Vento, M., & Khatri, P. (2018). Validation of the sepsis metascore for diagnosis of neonatal sepsis. Journal of the Pediatric Infectious Diseases Society, 7(2). https://doi.org/10.1093/jpids/pix021
Walker, O., Kenny, C. B., & Goel, N. (2019). Neonatal sepsis. In Paediatrics and Child Health (United Kingdom) (Vol. 29, Issue 6). https://doi.org/10.1016/j.paed.2019.03.003
Wang, Y., Zhao, J., Yao, Y., Yang, L., Zhao, D., & Liu, S. (2021). The Accuracy of 16S rRNA Polymerase Chain Reaction for the Diagnosis of Neonatal Sepsis: A Meta-Analysis. In BioMed Research International (Vol. 2021). https://doi.org/10.1155/2021/5550387
Wattal, C., Kler, N., Oberoi, J. K., Fursule, A., Kumar, A., & Thakur, A. (2020). Neonatal Sepsis: Mortality and Morbidity in Neonatal Sepsis due to Multidrug-Resistant (MDR) Organisms: Part 1. In Indian Journal of Pediatrics (Vol. 87, Issue 2). https://doi.org/10.1007/s12098-019-03106-z
Xin, Y., Shao, Y., Mu, W., Li, H., Zhou, Y., & Wang, C. (2022). Accuracy of the neutrophil-to-lymphocyte ratio for the diagnosis of neonatal sepsis: A systematic review and meta-analysis. BMJ Open, 12(12). https://doi.org/10.1136/bmjopen-2021-060391
Zea-Vera, A., & Ochoa, T. J. (2015). Challenges in the diagnosis and management of neonatal sepsis. Journal of Tropical Pediatrics, 61(1). https://doi.org/10.1093/tropej/fmu079
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