Meta Analysis of Factors Affecting the Birth of Infants with Labiopalatoschizis

  • Nining Sunarti STIKES Abdi Nusantara
  • Tri Mochartini STIKES Abdi Nusantara
Keywords: labiospalatoskizis, meta analysis, secondhand smoke


Labiospalatoskizis is caused by failure in the process of joining the lips while still in the fetus. This disorder can cause many disorders such as disorders such as eating disorders, speech disorders, ear irritation, and dental and oral disorders. Many factors can cause this disorder, namely exposure to cigarette smoke and metal exposure during pregnancy. The purpose of this meta-analysis was to analyze the effect of cigarette smoke exposure and metal exposure on labiospalatoskizis events. This study was conducted by systematic review and meta-analysis. Research data is sought from several indexing including: PubMed, Science Direct, Web of Science, Springer Link and Cochrane Database. By using the search keywords "smoking AND Orofacial Clefts", "heavy metal AND labiospalatoschizis", "smoke AND metal exposure AND cleft lift AND adjusted odds ratio", and "factors AND labiospalatoskizis AND adjusted odds ratio". There were 6 articles with 2 analysis results, namely: heavy metal exposure (OR: 3.18; 95% CI: 2.45 – 4.12; p value <0.001) and secondhand smoke exposure (OR: 5.40; 95% CI: 4.26 – 6.86; p value <0.001).


Spinder, N. P. (2019). Congenital anomalies in the offspring of occupationally exposed mothers: a systematic review and meta-analysis of studies using expert assessment . Human Reproduction, 34(5), 903-919.

Zheng, Z. X. (2019). Congenital malformations are associated with secondhand smoke among nonsmoking women: A meta‐analysis. Birth, 46(2), 222-233.

Oldereid, N. B. (2018). The effect of paternal factors on perinatal and paediatric outcomes: a systematic review and meta-analysis. Human reproduction update, 24(3), 320.

Takeuchi, M. Y. (2022). Association of maternal heavy metal exposure during pregnancy with isolated cleft lip and palate in offspring: Japan Environment and Children’s Study (JECS) cohort study. Plos one, 17(3), e0265648.

Garland, M. A. (2020). Environmental mechanisms of orofacial clefts. Birth defects research, 112(19), 1660-1698.

Suhl, J. R. (2018). Maternal occupational cadmium exposure and nonsyndromic orofacial clefts. Birth defects research, 110(7), 603-609.

Anggriant, V. R. (2022). The Correlation between High-Risk Pregnancy> 35 Years Old with Labioschizis Congenital Disorders. Journal of Medical and Health Studies, 3(3), 32-38.

Yin, X. e. (2019). Maternal alcohol consumption and oral clefts: a meta-analysis. British Journal of Oral and Maxillofacial Surgery, 57(9), pp.839–846.

Reynolds, K. Z. (2020). Genetics and signaling mechanisms of orofacial clefts. Birth defects research, 112(19), 1588-1634.

Garland, M. A. (2020). Role of epigenetics and miRNAs in orofacial clefts. Birth defects research, 112(19), 1635-1659.

Kawalec, A. e. (2015). Risk factors involved in orofacial cleft predisposition-review. Open Medicine (Poland), 10(1), pp.163–175.

Mbuyi-Musanzayi, S. K. (2018). Non-syndromic cleft lip and/or cleft palate: Epidemiology and risk factors in Lubumbashi (DR Congo), a case-control study. Journal of Cranio-Maxillofacial Surgery, 46(7), 1051-1058.

Kummer, A. (2018). A Pediatrician’s Guide to Communication Disorders Secondary to Cleft Lip/Palate. Pediatric Clinics of North America, 65(1), pp.31–46.

Kusuma, D. C. (2022). Asuhan Neonatus Dan Bayi Baru Lahir Dengan Kelainan Bawaan. Global Eksekutif Teknologi.

Afra, H. A. (2021). Article Review: Analysis of Patients with Labioschisis or Cleft Lip Review Artikel: Analisis Penderita Labioschisis atau Bibir Sumbing. In Prosiding Seminar Nasional Biologi , (pp. (Vol. 1, No. 2, pp. 1401-1407)).

Gumilar, M. S. (2020). Bibir Sumbing Labioschisis. PENYAKIT GIGI MULUT, 12.

Alade, A. A. (2022). Genetic and epigenetic studies in non‐syndromic oral clefts. Oral diseases, 28(5), 1339-1350.

Lacerda, R. H. (2021). Maternal Smoking Leads to Larger Cleft Palate Defects. Frontiers in Dental Medicine, 1, 632037.

How to Cite
Sunarti, N., & Mochartini, T. (2023). Meta Analysis of Factors Affecting the Birth of Infants with Labiopalatoschizis. Proceedings of the International Conference on Nursing and Health Sciences, 4(2), 433-438.