The Effect of Dayak Onion Extract on Lactic Acid Levels in Mice with FST Model
Keywords:
antioxidant, fatigue, lactic acid, onion dayak
Abstract
Intense physical exercise can increase lactic acid levels in the blood as a result of the anaerobic metabolism that occurs at that time. The impact of increased levels of lactic acid includes the occurrence of acidosis, damage to body cells, and fatigue which reduces muscle performance. Antioxidants can play a role in preventing body fatigue caused by oxidative stress. Onion Dayak (Eleutherine palmifolia) is a type of medicinal plant that is useful for health. The high content of antioxidants in Dayak onions can be used as an alternative anti-fatigue ingredient. This study aimed to look at the effect of the dose and duration of Dayak onion extract on lactic acid levels and physical activity in mice forced swimming test models. Type of Research Randomized Pre and Post-Test Control Group Design. Male White Mice (Sprague Dawley) 2 months old (weight 150-200g). Divided into 5 groups K- (the experimental group was not given Dayak onion extract, they were still given FST), K+ (the experimental group was given xanthine and FST), P1 (given Dayak onion extract at a dose of 50mg/200gBW), P2 (given the extract onion Dayak dose of 100mg/200gBB), P3 (given onion extract dose of 200mg/200gBW). Dayak onion extract was given for 28 days and given the forced swimming test, then the changes in lactic acid and physical activity endurance in swimming were observed.
References
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Kruk, J., Aboul-Enein, B. H., Duchnik, E., & Marchlewicz, M. (2022). Antioxidative properties of phenolic compounds and their effect on oxidative stress induced by severe physical exercise. Journal of Physiological Sciences, 72(1), 1–24. https://doi.org/10.1186/s12576-022-00845-1
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Mota, M. R., Dantas, R. A. E., Oliveira-Silva, I., Sales, M. M., da Costa Sotero, R., Espíndola Mota Venâncio, P., Teixeira Júnior, J., Chaves, S. N., & de Lima, F. D. (2017). Effect of self-paced active recovery and passive recovery on blood lactate removal following a 200 m freestyle swimming trial. Open Access Journal of Sports Medicine, Volume 8, 155–160. https://doi.org/10.2147/oajsm.s127948
Nanang, M., Fuad, N., Didik, R., Topo, S., & Panuwun, J. (2018). Effect of Alkaline Fluids to Blood pH and Lactic Acid Changes on Sub Maximal Physical Exercise. IOP Conference Series: Earth and Environmental Science, 197(1). https://doi.org/10.1088/1755-1315/197/1/012049
Nugraha, A. R., & Berawi, K. N. (2017). The Effect of High Intensity Interval Training (HIIT) toward Cardiorespiratory Fitness. Jurnal Majority, 20(1), 425.
Pedersen, T. H., Riisager, A., de Paoli, F. V., Chen, T. Y., & Nielsen, O. B. (2016). Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. Journal of General Physiology, 147(4), 291–308. https://doi.org/10.1085/jgp.201611582
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Sibagariang, M. O., & Simatupang, N. (2021). Pengaruh Pemberian Massage Terhadap Penurunan Kadar Asam Laktat Pada Mahasiswa Ilmu Keolahragaan Setelah Melakukan Aktivitas Fisik Anaerobik Lari Sprint 100 Meter Universitas Negeri Medan. Jurnal Kesehatan Dan Olahraga, 5(1), 54. https://doi.org/10.24114/ko.v5i1.30369
Sudarma, D. W., & Hasyati, N. (2018). Potensi Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr.) Dalam Mencegah Ulcerative Colitis Pada Mencit Yang Diinduksi DSS (Dextran Sulphate Sodium). Jurnal Ilmu Pangan Dan Hasil Pertanian, 2(1), 40–52.
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Wijayanti, S. D., & Hasyati, N. (2018). Potensi Ekstrak Umbi Bawang Dayak (Eleutherine Palmifolia (L.) Merr.) dalam Mencegah Ulcerative Colitis Pada Mencit Yang Diinduksi DSS (Dextran Sulfate Sodium). Jurnal Ilmu Pangan Dan Hasil Pertanian, 2(1), 40. https://doi.org/10.26877/jiphp.v2i1.2288
Yudapratama, A. T., & Novianry, V. (2018). Uji Efektivitas Astaxanthin terhadap Kadar Glutation pada Jaringan Ginjal Tikus Putih ( Rattus Norvegicus ) Jantan Galur Wistar yang diinduksi Formaldehid secara Oral Program Studi Kedokteran , FK UNTAN Departemen Biokimia , Program Studi Kedokteran , FK. Jurnal Cerebellum, 4(3), 1120–1126.
Zhao, Y., Butler, E. B., & Tan, M. (2013). Targeting cellular metabolism to improve cancer therapeutics. Cell Death and Disease, 4(3), 1–10. https://doi.org/10.1038/cddis.2013.60
Arcinthya, R. R., Dwitiyanti, D., Wulandari Iriansyah, Q., & Fergiana Putri, F. (2021). Potensi Fraksi Kayu Secang (Caesalpinia sappan L.) terhadap Penghambatan Xantin Oksidase dalam Menurunkan Kadar Asam Urat pada Hiperurisemia Potential Use of Sappan Wood (Caesalpinia sappan L.) Fractions in the Treatment of Hyperuricemia by Inhibition of. Pharmaceutical Journal of Indonesia, 18(01), 21–33.
Capasso, A. (2013). Antioxidant action and therapeutic efficacy of Allium sativum L. Molecules, 18(1), 690–700. https://doi.org/10.3390/molecules18010690
Claudea, N., Yuswi, R., Teknologi, J., Pertanian, H., Brawijaya, U., Veteran, J., & Korespondensi, P. (2017). Antioxidant Extraction of Bawang Dayak (Eleutherine Palmifolia) with Ultrasonic Bath (Study type of solvent and Extraction Time). Jurnal Pangan Dan Agroindustri, 5(1), 71–79.
Eş, I., Mousavi Khaneghah, A., Barba, F. J., Saraiva, J. A., Sant’Ana, A. S., & Hashemi, S. M. B. (2018). Recent advancements in lactic acid production - a review. Food Research International, 107(January), 763–770. https://doi.org/10.1016/j.foodres.2018.01.001
Febrinda, A. et. a. (2014). Hyperglycemic control and diabetes complication preventive activities of Bawang Dayak (Eleutherine palmifolia L. Merr.) bulbs extracts in alloxan-diabetic rats. International Food Research Journal, Vol. 21(Issue 4), p1405-1411. https://web.p.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=19854668&AN=97575316&h=FHbQdqL%2FQySmllfQXTUagIqd5oriN90zrDzS88BMcky2QTnvQnXxoAOegY42M9C6lwHUu8xaHmcRkJKghPyFHw%3D%3D&crl=c&resultNs=AdminWebAuth&resultLocal=E
Flora, R. (2015). Pengaruh Latihan Fisik Anaerobik Terhadap Kadar Laktat Plasma dan Kadar Laktat Jaringan Otot Jantung Tikus Wistar Effect Anaerobic Exercise on The Blood Lactate Levels and Myocardium Levels in Wistar Rats. Journal Article, 1, 40–42.
Gay, C., Chabaud, A., Guilley, E., & Coudeyre, E. (2016). Educating patients about the benefits of physical activity and exercise for their hip and knee osteoarthritis. Systematic literature review. Annals of Physical and Rehabilitation Medicine, 59(3), 174–183. https://doi.org/10.1016/j.rehab.2016.02.005
Gehlert, S., Bloch, W., & Suhr, F. (2015). Ca2+-dependent regulations and signaling in skeletal muscle: From electro-mechanical coupling to adaptation. International Journal of Molecular Sciences, 16(1), 1066–1095. https://doi.org/10.3390/ijms16011066
George, S., & Abrahamse, H. (2020). Redox potential of antioxidants in cancer progression and prevention. Antioxidants, 9(11), 1–21. https://doi.org/10.3390/antiox9111156
Glancy, B., Kane, D. A., Kavazis, A. N., Goodwin, M. L., Willis, W. T., & Gladden, L. B. (2021). Mitochondrial lactate metabolism: history and implications for exercise and disease. Journal of Physiology, 599(3), 863–888. https://doi.org/10.1113/JP278930
Gomes, E. C., Silva, A. N., & Oliveira, M. R. De. (2012). Oxidants, antioxidants, and the beneficial roles of exercise-induced production of reactive species. Oxidative Medicine and Cellular Longevity, 2012. https://doi.org/10.1155/2012/756132
Hargreaves, M., & Spriet, L. L. (2020). Skeletal muscle energy metabolism during exercise. Nature Metabolism, 2(9), 817–828. https://doi.org/10.1038/s42255-020-0251-4
Herlan, H., & Komarudin, K. (2020). Pengaruh Metode Latihan High-Intensity Interval Training (Tabata) terhadap Peningkatan Vo2Max Pelari Jarak Jauh. Jurnal Kepelatihan Olahraga, 12(1), 11–17. https://doi.org/10.17509/jko-upi.v12i1.24008
Kottmann, R. M., Kulkarni, A. A., Smolnycki, K. A., Lyda, E., Dahanayake, T., Salibi, R., Honnons, S., Jones, C., Isern, N. G., Hu, J. Z., Nathan, S. D., Grant, G., Phipps, R. P., & Sime, P. J. (2012). Lactic acid is elevated in idiopathic pulmonary fibrosis and induces myofibroblast differentiation via pH-dependent activation of transforming growth factor-β. American Journal of Respiratory and Critical Care Medicine, 186(8), 740–751. https://doi.org/10.1164/rccm.201201-0084OC
Kruk, J., Aboul-Enein, B. H., Duchnik, E., & Marchlewicz, M. (2022). Antioxidative properties of phenolic compounds and their effect on oxidative stress induced by severe physical exercise. Journal of Physiological Sciences, 72(1), 1–24. https://doi.org/10.1186/s12576-022-00845-1
Mardiana, M., Khofifah, N., & Lestari, Y. N. (2022). Branched Chain Amino Acid (Bcaa), Sitrulin, Bromelain Dan Muscle Injury. Bookchapter Kesehatan Masyarakat Universitas Negeri Semarang, 1, 128–160. https://doi.org/10.15294/km.v1i1.71
Matthews, M. J., Green, D., Matthews, H., & Swanwick, E. (2017). The effects of swimming fatigue on shoulder strength, range of motion, joint control, and performance in swimmers. Physical Therapy in Sport, 23, 118–122. https://doi.org/10.1016/j.ptsp.2016.08.011
Mota, M. R., Dantas, R. A. E., Oliveira-Silva, I., Sales, M. M., da Costa Sotero, R., Espíndola Mota Venâncio, P., Teixeira Júnior, J., Chaves, S. N., & de Lima, F. D. (2017). Effect of self-paced active recovery and passive recovery on blood lactate removal following a 200 m freestyle swimming trial. Open Access Journal of Sports Medicine, Volume 8, 155–160. https://doi.org/10.2147/oajsm.s127948
Nanang, M., Fuad, N., Didik, R., Topo, S., & Panuwun, J. (2018). Effect of Alkaline Fluids to Blood pH and Lactic Acid Changes on Sub Maximal Physical Exercise. IOP Conference Series: Earth and Environmental Science, 197(1). https://doi.org/10.1088/1755-1315/197/1/012049
Nugraha, A. R., & Berawi, K. N. (2017). The Effect of High Intensity Interval Training (HIIT) toward Cardiorespiratory Fitness. Jurnal Majority, 20(1), 425.
Pedersen, T. H., Riisager, A., de Paoli, F. V., Chen, T. Y., & Nielsen, O. B. (2016). Role of physiological ClC-1 Cl- ion channel regulation for the excitability and function of working skeletal muscle. Journal of General Physiology, 147(4), 291–308. https://doi.org/10.1085/jgp.201611582
Purnomo, M. (2011). Asam Laktat dan Aktivitas SOD Eritrosit pada Fase Pemulihan Setelah Latihan Submaksimal. Jurnal Media Ilmu Keolahragaan Indonesia, 1(2), 155–170. http://journal.unnes.ac.id/index.php/miki
Sibagariang, M. O., & Simatupang, N. (2021). Pengaruh Pemberian Massage Terhadap Penurunan Kadar Asam Laktat Pada Mahasiswa Ilmu Keolahragaan Setelah Melakukan Aktivitas Fisik Anaerobik Lari Sprint 100 Meter Universitas Negeri Medan. Jurnal Kesehatan Dan Olahraga, 5(1), 54. https://doi.org/10.24114/ko.v5i1.30369
Sudarma, D. W., & Hasyati, N. (2018). Potensi Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia (L.) Merr.) Dalam Mencegah Ulcerative Colitis Pada Mencit Yang Diinduksi DSS (Dextran Sulphate Sodium). Jurnal Ilmu Pangan Dan Hasil Pertanian, 2(1), 40–52.
Wigati, D., & Rahardian, R. R. (2018). Penetapan Standarisasi Non Spesifik Ekstrak Etanol Hasil Perkolasi Umbi Bawang Dayak (Eleutherine Palmifolia (L.)Merr). JIFFK : Jurnal Ilmu Farmasi Dan Farmasi Klinik, 15(2), 36. https://doi.org/10.31942/jiffk.v15i2.2564
Wijayanti, S. D., & Hasyati, N. (2018). Potensi Ekstrak Umbi Bawang Dayak (Eleutherine Palmifolia (L.) Merr.) dalam Mencegah Ulcerative Colitis Pada Mencit Yang Diinduksi DSS (Dextran Sulfate Sodium). Jurnal Ilmu Pangan Dan Hasil Pertanian, 2(1), 40. https://doi.org/10.26877/jiphp.v2i1.2288
Yudapratama, A. T., & Novianry, V. (2018). Uji Efektivitas Astaxanthin terhadap Kadar Glutation pada Jaringan Ginjal Tikus Putih ( Rattus Norvegicus ) Jantan Galur Wistar yang diinduksi Formaldehid secara Oral Program Studi Kedokteran , FK UNTAN Departemen Biokimia , Program Studi Kedokteran , FK. Jurnal Cerebellum, 4(3), 1120–1126.
Zhao, Y., Butler, E. B., & Tan, M. (2013). Targeting cellular metabolism to improve cancer therapeutics. Cell Death and Disease, 4(3), 1–10. https://doi.org/10.1038/cddis.2013.60
Published
2023-05-13
How to Cite
Ramadhani, A., Doewes, M., & Listyawati, S. (2023). The Effect of Dayak Onion Extract on Lactic Acid Levels in Mice with FST Model. Proceedings of the International Conference on Nursing and Health Sciences, 4(1), 1-8. https://doi.org/10.37287/picnhs.v4i1.1677
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Articles
