Hubungan Hiperurisemia dengan Disfungsi Seksual

Zahara Ayu Destriyanti

doi:10.37287/jppp.v4i1.837

Zahara Ayu Destriyanti Fakultas Kedokteran, Universitas Lampung

DOI: https://doi.org/10.37287/jppp.v4i1.837

Keywords: disfungsi seksual, gout, hiperurisemia

Abstract

Hubungan antara asam urat dan disfungsi seksual telah sering diselidiki oleh penelitian dalam beberapa dekade terakhir. Meskipun adanya faktor risiko dan komorbiditas yang mirip serta kemungkinan efek dari komplikasi gout jangka panjang pada kesehatan seksual, kesadaran akan hubungan ini sangat kurang dan mekanisme patogenetik hanya sebagian yang telah diidentifikasi. Dalam tinjauan ini bertujuan untuk menyelidiki bukti terkini mengenai mekanisme potensial yang menghubungkan disfungsi seksual dan asam urat. Sebuah pencarian literatur yang komprehensif dalam PubMed Central, Elsevier dan Google Cendekia dengan rentang waktu sepuluh tahun terakhir (2012-2022). Kata kunci yang digunakan adalah “disfungsi seksual”, “gout”, dan “hiperurisemia” yang menghasilkan 2.895 artikel kemudian dipilih 35 artikel yang dianggap relevan mengenai hubungan antara asam urat dan disfungsi seksual yang dilakukan untuk memberikan ringkasan bukti yang tersedia saat ini. Asam urat dan disfungsi seksual berbagi beberapa faktor risiko yang sama, termasuk diabetes, penyakit ginjal kronis, hipertensi, sindrom metabolik, dan penyakit pembuluh darah perifer. Serangan asam urat yang dipicu oleh respons peradangan yang intens menampilkan rasa sakit dan disabilitas yang parah, mengakibatkan fungsi seksual yang lebih buruk, tetapi tidak semua. Komplikasi asam urat jangka panjang, peradangan tingkat rendah dan beban psikologis asam urat memiliki dampak negatif pada kesehatan seksual.

References

Abdul Sultan A, Mallen C, Hayward R et al (2017) Gout and subsequent erectile dysfunction: a population-based cohort study from England. Arthritis Res Ther 19:123. https://doi.org/10.1186/s13075-017-1322-0

Alahverdi F, Kheirkhah M, Janani L (2020) Treatment outcomes of vaginal infections on sexual function. J Med Life 13:329–335

Arrabal-Polo MA, Arias-Santiago S, Lopez-Carmona Pintado F et al. (2012). Metabolic syndrome, hormone levels, and inflam- mation in patients with erectile dysfunction. Scientific World J 2012:272769. https://doi.org/10.1100/2012/272769

Bester J, Pretorius E (2016) Effects of IL-1β, IL-6 and IL-8 on erythrocytes, platelets and clot viscoelasticity. Sci Rep 6:32188. https://doi.org/10.1038/srep32188

Chandratre P, Mallen C, Richardson J et al (2018) Health-related quality of life in gout in primary care: baseline findings from a cohort study. Semin Arthritis Rheum 48:61–69. https://doi.org/10.1016/j.semarthrit.2017.12.005

Chen-Xu M, Yokose C, Rai SK et al (2019) Contemporary prevalence of gout and hyperuricemia in the united states and decadal trends: The National Health and Nutrition Examination Survey, 2007–2016. Arthritis Rheumatol 71:991–999. https://doi.org/10.1002/art.40807

Cox P, Gupta S, Zhao SS, Hughes DM (2021) The incidence and prevalence of cardiovascular diseases in gout: a system- atic review and meta-analysis. Rheumatol Int 41:1209–1219. https://doi.org/10.1007/s00296-021-04876-6

Dalbeth N, Choi HK, Joosten LAB et al (2019) Gout. Nat Rev Dis Primers 5:1–17. https://doi.org/10.1038/s41572-019-0115-y

Denys P, Chartier-Kastler E, Even A, Joussain C (2021) How to treat neurogenic bladder and sexual dysfunction after spinal cord lesion. Rev Neurol 177:589–593. https://doi.org/10.1016/j.neurol.2020.07.013

Fornaciari A, Giuffra V, Armocida E et al (2018) Gout in Duke Federico of Montefeltro (1422–1482): a new pearl of the Italian Renaissance. Clin Exp Rheumatol 36:15–20

Han Y, Han K, Zhang Y, Zeng X (2021) Serum 25-hydroxyvitamin D might be negatively associated with hyperuricemia in U.S. adults: an analysis of the National Health and Nutrition Examination Survey 2007–2014. J Endocrinol Invest. https://doi. org/10.1007/s40618-021-01637-x

Hatzichristou D, Kirana P-S, Banner L et al (2016) Diagnosing sexual dysfunction in men and women: sexual history taking and the role of symptom scales and questionnaires. J Sex Med 13:1166–1182. https://doi.org/10.1016/j.jsxm.2016.05.017

Ipekci T (2015) Sexual dysfunction in women with chronic renal failure. J Clin Anal Med. https://doi.org/10.4328/jcam.2429

Kim JH, Chung MK, Kang JY et al (2019) Insulin resistance is an independent predictor of erectile dysfunction in patients with gout. Korean J Intern Med 34:202–209. https://doi.org/10.3904/kjim.2016.350

Lorenz TK (2019) Interactions between inflammation and female sexual desire and arousal function. Curr Sex Health Rep 11:287– 299. https://doi.org/10.1007/s11930-019-00218-7

Luo L, Xiang Q, Deng Y et al (2019) Gout is associated with elevated risk of erectile dysfunction: a systematic review and meta-analysis. Rheumatol Int 39:1527–1535. https://doi.org/10.1007/s00296-019-04365-x

McCabe MP, Sharlip ID, Lewis R et al (2016) Incidence and prevalence of sexual dysfunction in women and men: a consensus statement from the Fourth International Consultation on Sexual Medicine 2015. J Sex Med 13:144–152. https://doi.org/10.1016/j.jsxm.2015.12.034

Mohamad N-V, Wong SK, Wan Hasan WN et al (2019) The relationship between circulating testosterone and inflammatory cytokines in men. Aging Male 22:129–140. https://doi.org/10.1080/13685538.2018.1482487

Maseroli E, Fanni E, Cipriani S et al (2016) Cardiometabolic risk and female sexuality: focus on clitoral vascular resistance. J Sex Med 13:1651–1661. https://doi.org/10.1016/j.jsxm.2016. 09.009

Mollaioli D, Ciocca G, Limoncin E et al (2020) Lifestyles and sexuality in men and women: the gender perspective in sexual medicine. Reprod Biol Endocrinol 18:10. https://doi.org/10.1186/s12958-019-0557-9

Parish SJ, Cottler-Casanova S, Clayton AH et al (2021) The evolution of the female sexual disorder/dysfunction definitions, nomenclature, and classifications: a review of DSM, ICSM, ISS- WSH, and ICD. Sex Med Rev 9:36–56. https://doi.org/10.1016/j. sxmr.2020.05.001

Park JS, Kang M, Song J-S et al (2020) Trends of gout preva- lence in South Korea based on medical utilization: a national health insurance service database (2002∼2015). J Rheum Dis 27:174–181. https://doi.org/10.4078/jrd.2020.27.3.174

Park K, Gupta NK, Olweny EO, Schlesinger N (2021) Beyond arthritis: understanding the influence of gout on erectile func- tion: a systematic review. Urology 153:19–27. https://doi.org/10.1016/j.urology.2020.12.005

Pyke RE (2020) Sexual performance anxiety. Sex Med Rev 8:183–190. https://doi.org/10.1016/j.sxmr.2019.07.001

Rastrelli G, Maggi M (2017) Erectile dysfunction in fit and healthy young men psychological or pathological. Transl Androl Urol 6:79–90

Roughley MJ, Belcher J, Mallen CD, Roddy E (2015) Gout and risk of chronic kidney disease and nephrolithiasis: meta- analysis of observational studies. Arthritis Res Ther 17:90. https://doi.org/10.1186/s13075-015-0610-9

Salonia A, Bettocchi C, Boeri L et al (2021) European association of urology guidelines on sexual and reproductive health-2021 update: male sexual dysfunction. Eur Urol 80:333–357. https://doi.org/10.1016/j.eururo.2021.06.007

Singh JA, Ramachandaran R, Yu S et al (2017) Is gout a risk equivalent to diabetes for stroke and myocardial infarction? A retrospective claims database study. Arthritis Res Ther 19:228. https://doi.org/10.1186/s13075-017-1427-5

Syed AAS, He L, Shi Y (2020) The potential effect of aberrant testosterone levels on common diseases: a Mendelian randomiza- tion study. Genes 11:721. https://doi.org/10.3390/genes11070721

Totaro M, Dimarakis S, Castellini C et al (2021) Erectile dys- function in hyperuricemia: a prevalence meta-analysis and meta- regression study. Andrology. https://doi.org/10.1111/andr.13088

Trovăo JN, & Serefoglu EC . (2018). Neurobiology of male sexual dysfunctions in psychiatric disorders: the cases of depression, anxiety, mania and schizophrenia. Int J Impot Res 30:279–286. https://doi.org/10.1038/s41443-018-0077-8

Tuokko AT, Murtola T, Korhonen P, Kaipia A (2021) Hyper- uricemia is not an independent predictor of erectile dysfunction. Sex Med Today 9:100319. https://doi.org/10.1016/j.esxm.2020. 100319

Yafi FA, Jenkins L, Albersen M et al (2016) Erectile dysfunc- tion. Nat Rev Dis Primers 2:16003. https://doi.org/10.1038/nrdp.2016.3

Yu W, Cheng J-D (2020) Uric acid and cardiovascular disease: an update from molecular mechanism to clinical perspective. Front Pharmacol 11:582680. https://doi.org/10.3389/fphar.2020. 582680

Zhou W, Zhu J, Guo J et al (2020) Health-related quality of life assessed by Gout Impact Scale (GIS) in Chinese patients with gout. Curr Med Res Opin 36:2071–2078. https://doi.org/ 10.1080/03007995.2020.1840341