Gambaran Kadar SGOT dan SGPT pada Pasien Pasca Induksi Anestesi Umum: Studi
Abstract
Serum Glutamate Oxaloacetate Transaminase (SGOT) dan Serum Glutamate Pyruvate Transaminase (SGPT) adalah enzim yang dihasilkan oleh hati dan berperan penting dalam mendeteksi kerusakan hati. Peningkatan kadar enzim ini dapat menjadi indikasi awal hepatotoksisitas, khususnya setelah penggunaan anestesi umum. Penelitian ini bertujuan untuk menganalisis kadar SGOT dan SGPT pada pasien pasca induksi anestesi umum di RSU Nirmala Purbalingga. Penelitian ini menggunakan desain deskriptif dengan data sekunder yang dikumpulkan melalui checklist. Sampel terdiri dari 60 pasien yang diambil dengan teknik purposive sampling di ruang IBS RSU Nirmala Purbalingga selama periode Juli hingga Agustus 2024. Hasil penelitian menunjukkan mayoritas responden berusia dewasa (61,7%), berjenis kelamin laki-laki (51,7%), dengan nilai SGOT normal (58,3%) dan SGPT normal (63,3%). Persentase jenis operasi antara bedah minor dan mayor sama (50%). Pasien lansia dan yang menjalani operasi mayor lebih berisiko mengalami peningkatan kadar SGOT dan SGPT. Penelitian ini menekankan pentingnya pemantauan fungsi hati pada pasien yang menjalani anestesi umum, terutama pada kelompok usia dan jenis operasi tertentu.
References
C, S. D. (2011). Buku ajar bedah. EGC.
Charni-Natan, M., Aloni-Grinstein, R., Osher, E., & Rotter, V. (2019). Liver and Steroid Hormones—Can a Touch of p53 Make a Difference? Frontiers in Endocrinology, 10(JUN), 374. https://doi.org/10.3389/FENDO.2019.00374
Dinis-Oliveira, R. J. (2018a). Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects. BioMed Research International, 2018. https://doi.org/10.1155/2018/6852857
Dinis-Oliveira, R. J. (2018b). Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects. BioMed Research International, 2018. https://doi.org/10.1155/2018/6852857
Farag, M., Veres, G., Szabó, G., Ruhparwar, A., Karck, M., & Arif, R. (2019). Hyperbilirubinaemia after cardiac surgery: the point of no return. ESC Heart Failure, 6(4), 694–700. https://doi.org/10.1002/EHF2.12447
Gomes, T., Juurlink, D. N., Antoniou, T., Mamdani, M. M., Paterson, J. M., & van den Brink, W. (2017). Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study. PLoS Medicine, 14(10). https://doi.org/10.1371/JOURNAL.PMED.1002396
Kapoor, D., Perwaiz, A., Singh, A., Kumar, A. N., & Chaudhary, A. (2023). Factors predicting 30-day mortality after pancreaticoduodenectomy—the impact of elevated aspartate aminotransferase. Langenbeck’s Archives of Surgery, 408(1), 1–10. https://doi.org/10.1007/S00423-023-02865-W/METRICS
Lee, A. S., Persoff, J., & Lange, S. M. (2023). Liver Function Tests. Mayo Clinic Medical Manual, 373–387. https://doi.org/10.1201/b14283-48
Mutia, L., Novitasari, D., Burhan, A., Nursing, A., & Program, S. (2024). The Relationship Between Pre-Anesthesia Anxiety and the Incidence of Post-Operative Nausea and Vomiting (PONV) in Patients Undergoing General. Scholar.Archive.Org, 2(1). https://doi.org/10.61716/jnj.v2i1.37
N. Margarita Rehatta, Elizeus Hanindito, A. R. T. (2019). Anestesiologi dan Terapi Intensif. Gramedia pustaka utama.
Nuryawan, I. (2009). Perbedaan Pengaruh Pemberian Tiopental Danpropofol Terhadap Kadar Serumaminotransferase Pada Induksi Anestesiumumthe Difference Between Effects Of Propofol Andthiopental Administration On Aminotransferaseserum Level In General Anesthesia Induction.
Oh, S. K., Lim, B. G., Kim, Y. S., & Kim, S. S. (2020a).
Comparison of the Postoperative Liver Function Between Total Intravenous Anesthesia and Inhalation Anesthesia in Patients with Preoperatively Elevated Liver Transaminase Levels: A Retrospective Cohort Study
. Therapeutics and Clinical Risk Management, 16, 223–232. https://doi.org/10.2147/TCRM.S248441Oh, S. K., Lim, B. G., Kim, Y. S., & Kim, S. S. (2020b). Comparison of the postoperative liver function between total intravenous anesthesia and inhalation anesthesia in patients with preoperatively elevated liver transaminase levels: A retrospective cohort study. Therapeutics and Clinical Risk Management, 16, 223–232. https://doi.org/10.2147/TCRM.S248441
Patricia A. Potter, A. G. (2015). Buku Ajar Fundamental Keperawatan (7th ed.). EGC.
Sjamsuhidajat, R. W. K. (2016). Buku Ajar Ilmu Bedah Sjamsuhidajat-de jong (3rd ed.). EGC.
Susa, S. T., Hussain, A., & Preuss, C. V. (2023). Drug Metabolism. Pharmacognosy: Fundamentals, Applications, and Strategies, Second Edition, 597–624. https://doi.org/10.1016/B978-0-443-18657-8.00029-3
Van Limmen, J., Wyffels, P., Berrevoet, F., Vanlander, A., Coeman, L., Wouters, P., De Hert, S., & De Baerdemaeker, L. (2020). Effects of propofol and sevoflurane on hepatic blood flow: A randomized controlled trial. BMC Anesthesiology, 20(1), 1–11. https://doi.org/10.1186/S12871-020-01150-3/TABLES/4



