Perbandingan Gambaran Histologis Ginjal Mencit (Mus Musculus) yang Dipapar Radiasi Gelombang Elektromagnetik Telepon Seluler 3G dan 4G

Keywords: elektromagnetik, ginjal, mus musculus, radiasi, stres oksidatif

Abstract

Paparan radiasi gelombang elektromagnetik telepon seluler dapat menyebabkan stres oksidatif pada ginjal. Radiasi yang dipancarkan mungkin lebih banyak diabsorbsi oleh ginjal karena telepon seluler sering dibawa di sabuk / saku celana. Penelitian ini bertujuan untuk mengetahui perbandingan gambaran histologis ginjal mencit (Mus musculus) yang diinduksi radiasi gelombang elektromagnetik telepon seluler 3G dan 4G. Penelitian ini menggunakan sampel 29 ekor mencit yang dibagi ke dalam 3 kelompok, yaitu kelompok tanpa paparan, kelompok dengan paparan radiasi elektromagnetik 3G, dan kelompok dengan paparan radiasi elektromagnetik 4G. Paparan diberikan dengan durasi 1 jam/hari selama 30 hari. Ciri histologis yang diukur adalah luas glomerulus dan luas ruang kapsula bowman. Kami mengamati bahwa tidak ada perbedaan antara kelompok 3G dan 4G pada luas glomerulus (p> 0,05) dan luas ruang kapsula bowman (p> 0,05). Dapat disimpulkan bahwa tidak ada perbedaan gambaran histologis ginjal mencit (Mus musculus) yang diinduksi radiasi gelombang elektromagnetik telepon seluler 3G dan 4G.

References

Al-Glaib, B., Al-Dardfi, M., Al-Tuhami, A., Elgenaidi, A., & Dkhil, M. (2008). A Technical Report on the Effect of Electromagnetic Radiation From a Mobile Phone on Mice Organs. Libyan Journal of Medicine, 3(1), 8–9. https://doi.org/10.4176/080107

Ali, M., Butt, S. A., & Hamid, S. (2017). Effect of Electromagnetic Field From 2g, 3g and 4g Mobile Phones on the Organization of Purkinje Cell Layer of Rat Cerebellum. Pakistan Armed Forces Medical Journal, 67.

Bahaodini, A., Owjfard, M., Tamadon, A., & Jafari, S. M. (2015). Low frequency electromagnetic fields long-term exposure effects on testicular histology, sperm quality and testosterone levels of male rats. Asian Pacific Journal of Reproduction, 4(3), 195–200. https://doi.org/10.1016/J.APJR.2015.06.001

Bello, A. K., Alrukhaimi, M., Ashuntantang, G. E., Basnet, S., Rotter, R. C., Douthat, W. G., Kazancioglu, R., Köttgen, A., Nangaku, M., Powe, N. R., White, S. L., Wheeler, D. C., & Moe, O. (2017). Complications of chronic kidney disease: current state, knowledge gaps, and strategy for action. Kidney International Supplements, 7(2), 122. https://doi.org/10.1016/J.KISU.2017.07.007

Duni, A., Liakopoulos, V., Roumeliotis, S., Peschos, D., & Dounousi, E. (2019). Oxidative Stress in the Pathogenesis and Evolution of Chronic Kidney Disease: Untangling Ariadne’s Thread. International Journal of Molecular Sciences, 20(15). https://doi.org/10.3390/IJMS20153711

Emre, M., Cetiner, S., Zencir, S., Unlukurt, I., Kahraman, I., & Topcu, Z. (2011). Oxidative stress and apoptosis in relation to exposure to magnetic field. Cell Biochemistry and Biophysics, 59(2), 71–77. https://doi.org/10.1007/S12013-010-9113-0

Fitzpatrick, S. G., & Gordon, S. C. (2018). Cell Injury, Adaptation, and Necrosis. Apoptosis and Beyond: The Many Ways Cells Die, 83–98. https://doi.org/10.1002/9781119432463.CH5

Gwinner, W., Plasger, J., Brandes, R. P., Kubat, B., Schulze, M., Regele, H., Kerjaschki, D., Olbricht, C. J., & Koch, K. M. (1999). Role of xanthine oxidase in passive Heymann nephritis in rats. Journal of the American Society of Nephrology : JASN, 10(3), 538–544. https://doi.org/10.1681/ASN.V103538

Hanafi, N., Eid, F., & El-Dahshan, A. (2012). Radiation Emitted From Mobile Phone Induces Amyloidosis Features in Some Tissues of Infant Mice. The Egyptian Journal of Hospital Medicine, 47, 132–144.

Hoy, W. E., Douglas-Denton, R. N., Hughson, M. D., Cass, A., Johnson, K., & Bertram, J. F. (2003). A stereological study of glomerular number and volume: Preliminary findings in a multiracial study of kidneys at autopsy. Kidney International, 63(83), S31–S37. https://doi.org/10.1046/J.1523-1755.63.S83.8.X

Ishaq Khayyat, L. (2011). The histopathological effects of an electromagnetic field on the kidney and testis of mice. EurAsian Journal of Biosciences, 103–109. https://doi.org/10.5053/ejobios.2011.5.0.12

Kumar, V., Abbas, A., & Aster, J. (2017). Robbins Basic Pathology (10th ed.). Elsevier. https://www.elsevier.com/books/robbins-basic-pathology/kumar/978-0-323-35317-5

Marshall, C. B., & Shankland, S. J. (2006). Cell cycle and glomerular disease: a minireview. Nephron. Experimental Nephrology, 102(2). https://doi.org/10.1159/000088400

Miesen, L., Steenbergen, E., & Smeets, B. (2017). Parietal cells—new perspectives in glomerular disease. Cell and Tissue Research, 369(1), 237. https://doi.org/10.1007/S00441-017-2600-5

Mugunthan, D. (2014). Exposure of mice to 900 - 1900 MHz radiations from cell phone resulting in microscopic changes in the kidney.International Journal of Current Research and Review.2014,Volume 6,Issue 16; Page.44-49.

Neale, T. J., Ojha, P. P., Exner, M., Poczewski, H., Rüger, B., Witztum, J. L., Davis, P., & Kerjaschki, D. (1994). Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. The Journal of Clinical Investigation, 94(4), 1577–1584. https://doi.org/10.1172/JCI117499

Oktem, F., Ozguner, F., Mollaoglu, H., Koyu, A., & Uz, E. (2005). Oxidative Damage in the Kidney Induced by 900-MHz-Emitted Mobile Phone: Protection by Melatonin. Archives of Medical Research, 36(4), 350–355. https://doi.org/10.1016/J.ARCMED.2005.03.021

Pfeilschifter, J., & Beck, K.-F. (2011). Oxidative Stress Injury in Glomerular Mesangium. Studies on Renal Disorders, 3–23. https://doi.org/10.1007/978-1-60761-857-7_1

Ragy, M. M. (2015). Effect of exposure and withdrawal of 900-MHz-electromagnetic waves on brain, kidney and liver oxidative stress and some biochemical parameters in male rats. Electromagnetic Biology and Medicine, 34(4), 279–284. https://doi.org/10.3109/15368378.2014.906446

Richard Kitching, A., & Hutton, H. L. (2016). The Players: Cells Involved in Glomerular Disease. Clinical Journal of the American Society of Nephrology : CJASN, 11(9), 1664–1674. https://doi.org/10.2215/CJN.13791215

Romagnani, P. (2011). Parietal Epithelial Cells: Their Role in Health and Disease. Experimental Models for Renal Diseases: Pathogenesis and Diagnosis, 169, 23–36. https://doi.org/10.1159/000313943

Saikhedkar, N., Bhatnagar, M., Jain, A., Sukhwal, P., Sharma, C., & Jaiswal, N. (2014). Effects of mobile phone radiation (900 MHz radiofrequency) on structure and functions of rat brain. Http://Dx.Doi.Org/10.1179/1743132814Y.0000000392, 36(12), 1072–1079. https://doi.org/10.1179/1743132814Y.0000000392

Sasaki, T., Tsuboi, N., Haruhara, K., Okabayashi, Y., Kanzaki, G., Koike, K., Kobayashi, A., Yamamoto, I., Ogura, M., & Yokoo, T. (2018). Bowman Capsule Volume and Related Factors in Adults With Normal Renal Function. Kidney International Reports, 3(2), 314–320. https://doi.org/10.1016/J.EKIR.2017.10.007

Statista. (2011). Number of 4G mobile subscribers worldwide 2010-2020 | Statista. [online] Tersedia dari: https://www.statista.com/statistics/274774/forecast-of-mobile-phone-users-worldwide/ [Diakses 22 Mar. 2023]

Statista. (2016). Number of mobile phone users worldwide 2015-2020 | Statista. [online] Tersedia dari: https://www.statista.com/statistics/226101/global-4g-mobile-subscriber-forecast/ [Diakses 22 Mar. 2023]

Tamay-Cach, F., Quintana-Pérez, J. C., Trujillo-Ferrara, J. G., Cuevas-Hernández, R. I., Del Valle-Mondragón, L., García-Trejo, E. M., & Arellano-Mendoza, M. G. (2015). A review of the impact of oxidative stress and some antioxidant therapies on renal damage. Http://Dx.Doi.Org/10.3109/0886022X.2015.1120097, 38(2), 171–175. https://doi.org/10.3109/0886022X.2015.1120097

Wajcman, J., Bittman, M., Jones, P., Johnstone, L., & Brown, J. (2007). The impact of the mobile phone on work/life balance. Research School of Social Sciences, P1–P27.

Wessapan, T., & Rattanadecho, P. (2018). Temperature induced in human organs due to near-field and far-field electromagnetic exposure effects. International Journal of Heat and Mass Transfer, 119, 65–76. https://doi.org/10.1016/J.IJHEATMASSTRANSFER.2017.11.088

Zare, S., Alivandi, S., & Ebadi, A. G. (2007). Histological studies of the low frequency electromagnetic fields effect on liver, testes and kidney in guinea pigs. World Applied Sciences Journal, 2(5), 509–511. http://idosi.org/wasj/wasj2(5)/13.pdf.

Published
2023-03-24
How to Cite
Pradana, A., Salsabila, A., Sari, D., Setiawati, R., & Susanto, J. (2023). Perbandingan Gambaran Histologis Ginjal Mencit (Mus Musculus) yang Dipapar Radiasi Gelombang Elektromagnetik Telepon Seluler 3G dan 4G. Jurnal Penelitian Perawat Profesional, 5(2), 713-720. https://doi.org/10.37287/jppp.v5i2.1575