Risk Factors Associated with Severe Pre-Eclampsia
Abstract
PEB (severe pre-eclampsia) is influenced by several variables, including maternal age during pregnancy, parity, gestational age, number of fetuses, frequency of antenatal care (ANC) appointments, and any history of hypertension. Identifying these elements among particular groups helps to direct successful therapeutic interventions and inform public health policies. This study was designed as a case-control study and used analytic observational techniques. Date were collectedfrom the medical records of women giving birth and without preeclampsia at the obstetrics and gynecology departement of Dr. Slamet General Hospital in Garut. The results of bivariate analysis using the chi-square test showed that there was no significant relationship between risk factors, including maternal age, parity, gestational age, number of fetuses, and ANC visits, with p-values greater than 0.05. based on multivariate analysis using logistic regression testing, it was found that pregnant women over the age of 35 had a higher risk of developing severe preeclampsia, with a significance value of p = 0.034. these findings indicate that maternal age over 35 and a history of hypertension play a role in increasing the likelihood of PEB.
References
Azhari Fadhilah, Jusuf Sulaeman Effendi, & Susanti Dharmmika. (2024). Gambaran Karakteristik Ibu Hamil pada Kejadian Preeklamsia Awitan Dini dan Preeklamsia Awitan Lambat di Rumah Sakit Al-Ihsan Kabupaten Bandung 2022. Bandung Conference Series: Medical Science, 4(1), 318–324. https://doi.org/10.29313/bcsms.v4i1.10775
Bisri, D. Y., & Bisri, T. (2025). Preeklampsia dan Risiko Penyakit Kardiovaskuler di Masa Depan Preeclampsia and Risk of Future Cardiovascular Disease. Jurnal Anestesi Obstetri Indonesia, 8, 61–68. https://www.jurnalanestesiobstetri-indonesia.id/ojs/index.php/Obstetri/article/view/194/165%0A
Boadu, W. I. O., Anto, E. O., Asamoah, A. B., Ansah, E., Scott, G. Y., Korsah, E. E., Frimpong, J., Tamakloe, V. C. K. T., Nyantakyi, M., Anto, A. O., Donkoh, E. T., Boadu, K. O., Duneeh, R. V., Ayensu, F., & Obirikorang, C. (2025). Gestational Age–Specific Prevalence of Preeclampsia Among Pregnant Women in Ghana: A Hospital-Based Retrospective Observational Study. BioMed Research International, 2025(1), 39–40. https://doi.org/10.1155/bmri/4728838
Bratasena, B., & Henriette, J. (2021). the Relationship Between Preeclampsia and Parity in Maternal Birth in Rsud Muhammad Sani Karimun. Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam, 10(2), 39–44. https://doi.org/10.37776/zked.v10i2.513
Das, S., Das, R., Bajracharya, R., Baral, G., Jabegu, B., Odland, J. Ø., & Odland, M. L. (2019). Incidence and risk factors of pre-eclampsia in the paropakar maternity and women’s hospital, Nepal: A retrospective study. International Journal of Environmental Research and Public Health, 16(19), 1–8. https://doi.org/10.3390/ijerph16193571
Desriva, N., Sansuwito, B. T., & Dioso, R. I. (2023). Compliance With Antenatal With The Event of Preeclampsia in Pregnant Women Ingaruda Health Center, Pekanbaru City. Al Insyirah International Scientific Conference on Health, 4(1), 62–66.
Fishel Bartal, M., Lindheimer, M. D., & Sibai, B. M. (2022). Proteinuria during pregnancy: definition, pathophysiology, methodology, and clinical significance. American Journal of Obstetrics and Gynecology, 226(2), S819–S834. https://doi.org/10.1016/j.ajog.2020.08.108
Han, Q., Zheng, S., Chen, R., Zhang, H., & Yan, J. (2022). A New Model for the Predicting the Risk of Preeclampsia in Twin Pregnancy. Frontiers in Physiology, 13(April), 1–9. https://doi.org/10.3389/fphys.2022.850149
Javandoust Gharehbagh F, Soltani-Zangbar MS, Y. Y. (2024). Immunological mechanismr in preeclampsia: Anarrative review. Reproductive Immunology, 164, 104282. https://doi.org/10.1016/j.jri.2024.104282
Karrar SA, Martingano DJ, H. P. (2024). Preeclampsia. StatPearls. https://www.ncbi.nlm.nih.gov/books/NBK570611/?utm_source=chatgpt.com
Kasma, Masita Fujiko, Haizah Nurdin, Irwan, & Abadi Aman. (2024). Karakteristik Pasien Preeklampsia pada Ibu Bersalin di RSIA Sitti Khadijah 1 Periode 2022-2023. Fakumi Medical Journal: Jurnal Mahasiswa Kedokteran, 4(2), 103–110. https://doi.org/10.33096/fmj.v4i2.386
Kusmintarti, A., Kirana, A. N., Pembayun, E. L., & Jayanti, K. (2024). Usia Dan Paritas Sebagai Faktor Resiko Terjadinya Preeklampsia. Jurnal Bidan Srikandi, 2(1), 7–12. https://doi.org/10.35760/jbs.2024.v2i1.11717
Laine, K., Murzakanova, G., Sole, K. B., Pay, A. D., Heradstveit, S., & Raïsänen, S. (2019). Prevalence and risk of pre-eclampsia and gestational hypertension in twin pregnancies: A population-based register study. BMJ Open, 9(7), 1–8. https://doi.org/10.1136/bmjopen-2019-029908
Lopppies, M. Y., Angkejaya, O. W., & Titaley, C. R. (2024). Karakteristik Penggunaan Obat Gastroprotektor Pada Pasien Kritis di ICU RSUD Dr M. Haulussy Ambon. Jurnal Ners, 8(2), 1593–1601.
Mardiyah, N., Ernawati, E., & Anis, W. (2022). Antenatal Care and Maternal Outcome of Preeclampsia. Indonesian Midwifery and Health Sciences Journal, 6(3), 298–309. https://doi.org/10.20473/imhsj.v6i3.2022.298-309
Meazaw, M. W., Chojenta, C., Muluneh, M. D., & Loxton, D. (2020). Systematic and meta-analysis of factors associated with preeclampsia and eclampsia in sub-Saharan Africa. PLoS ONE, 15(8 August), 1–23. https://doi.org/10.1371/journal.pone.0237600
Nie, X., Xu, Z., & Ren, H. (2024). Analysis of risk factors of preeclampsia in pregnant women with chronic hypertension and its impact on pregnancy outcomes. BMC Pregnancy and Childbirth, 24(1), 1–8. https://doi.org/10.1186/s12884-024-06476-1
Oxford University Press. (2024). Simple random sample. In A Dictionary of Psychology.
Retnaningtyas, E. (2021). Preeklampsi dan Asuhan Kebidanan Pada Preeklampsi (Issue 37).
Rospia, E. D., Novidaswati, A., & Cahyaningtyas, D. K. (2021). Hubungan Paritas dengan Kejadian Preeklampsia Berat di RSUD Panembahan Senopati Bantul. Journal Center of Research Publication in Midwifery and Nursing, 5(2), 24–30. https://doi.org/10.36474/caring.v5i2.203
Shaikh, N., Nahid, S., Ummunnisa, F., Fatima, I., Hilani, M., Gul, A., Basha, A. Al, Yahia, W., Hail, F. Al, Elfil, H., Abdalla, E., Nainthramveetil, M. M., Imraan, M. A., Zubair, M., Khan, S., Korichi, N., Alkhawaga, S., Ismail, H., Yaqoob, S., & Khelaifi, M. A. M. S. Al. (2021). Preeclampsia: From Etiopathology to Organ Dysfunction. In H. Abduljabbar (Ed.), Preeclampsia. IntechOpen. https://doi.org/10.5772/intechopen.101240
Sium, A. F., Lucero-Prisno, D. E. I. I. I., & Gudu, W. (2022). Perinatal outcomes of twin pregnancies complicated with preeclampsia at a tertiary hospital in Ethiopia: A case-control study. Public Health Challenges, 1(4), 2–7. https://doi.org/10.1002/puh2.37
Stefańska, K., Zieliński, M., Zamkowska, D., Adamski, P., Jassem-Bobowicz, J., Piekarska, K., Jankowiak, M., Leszczyńska, K., Światkowska-Stodulska˛, R., Preis, K., Trzonkowski, P., & Marek-Trzonkowska, N. (2020). Comparisons of dipstick test, urine protein-to-creatine ratio, and total protein measurement for the diagnosis of preeclampsia. International Journal of Environmental Research and Public Health, 17(12), 1–9. https://doi.org/10.3390/ijerph17124195
Sutan, R., Aminuddin, N. A., & Mahdy, Z. A. (2022). Prevalence, maternal characteristics, and birth outcomes of preeclampsia: A cross-sectional study in a single tertiary healthcare center in greater Kuala Lumpur Malaysia. Frontiers in Public Health, 10. https://doi.org/10.3389/fpubh.2022.973271
Syairaji, M., Nurdiati, D. S., Wiratama, B. S., Prüst, Z. D., Bloemenkamp, K. W. M., & Verschueren, K. J. C. (2024). Trends and causes of maternal mortality in Indonesia: a systematic review. BMC Pregnancy and Childbirth, 24(1), 1–14. https://doi.org/10.1186/s12884-024-06687-6
Tanner MS, Davey MA, Mol BW, R. D. (2022). The evolution of the diagnostic criteria of preeclampsia-eclampsia. AJOG (American Journl of Obstetrics Gynecology), 226(2), S835–S843. https://doi.org/10.1016/j.ajog.2021.11.1371
Tesfa, E., Munshea, A., Nibret, E., & Gizaw, S. T. (2023). Determinants of pre-eclampsia among pregnant women attending antenatal care and delivery services at Bahir Dar public hospitals, northwest Ethiopia: A case-control study. Health Science Reports, 6(7), 1–11. https://doi.org/10.1002/hsr2.1440
Utari, D., & Hasibuanb, H. (2022). Relationship Between Age Of Pregnant Women And Incidence Of Preeclampsia At Haji General Hospital Medan. Kedokteran Ibnu Nafis, 11(1), 882–887. https://doi.org/10.1109/TSMC.1976.4309487
Wulandari, E. S., Ernawati, E., & Nuswantoro, D. (2021). Risk Factors of Preeclampsia With Severe Features and Its Complications. Indonesian Midwifery and Health Sciences Journal, 5(1), 29–37. https://doi.org/10.20473/imhsj.v5i1.2021.29-37
Zhu, J., An, P., Zhao, H., Zhao, Y., Zhou, J., Zhou, Q., Li, X., & Xiong, Y. (2023). Optimal cutoffs of growth discordance for the risk of preeclampsia in twin pregnancies: A single-center retrospective cohort study. Frontiers in Cardiovascular Medicine, 9(January), 1–7. https://doi.org/10.3389/fcvm.2022.1073729.
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