A Scoping Review: Catechin-Rich Gambir as A Potential Functional for the Obesity Management
Keywords:
catechin, gambir, obesity
Abstract
Obesity is a complex and severe problem whose prevalence has increased significantly in the last few decades, posing a significant risk to human health. Various weight loss strategies are currently used, and different weight loss supplements are widely available. However, the effectiveness of some of these food supplements is still unknown. Thus, alternative therapy with a pharmaconutrition macronutrient approach is needed. A scoping review is necessary to scope the current article, summarize the scientific data, and guide future investigation into the potential use of catechin-rich gambir for obesity management. Results: Four databases were searched systematically. The scoping review covered articles published after 2013. A total of 251 articles were collected, and five studies (2 experimental studies) met the inclusion criteria. The synthesis results show that catechin-rich gambir has the potential a function in obesity management therapy. This mechanism, through the anti-obesity effect of catechins, is related to the uptake and synthesis of adipose tissue in obese individuals. Conclusions: Available evidence recommends that the catechin content in gambir has the potential for pharmaconutrition therapy for obesity management.
References
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Sugiura, C., Nishimatsu, S., Moriyama, T., Ozasa, S., Kawada, T., & Sayama, K. (2012). Catechins and caffeine inhibit fat accumulation in mice through the improvement of hepatic lipid metabolism. Journal of Obesity, 2012, 1–10. https://doi.org/10.1155/2012/520510
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Torres, J.-L., Usategui-Martín, R., Hernández-Cosido, L., Bernardo, E., Manzanedo-Bueno, L., Hernández-García, I., Mateos-Díaz, A.-M., Rozo, O., Matesanz, N., Salete-Granado, D., Chamorro, A.-J., Carbonell, C., Garcia-Macia, M., González-Sarmiento, R., Sabio, G., Muñoz-Bellvís, L., & Marcos, M. (2022). PPAR-γ Gene Expression in Human Adipose Tissue Is Associated with Weight Loss After Sleeve Gastrectomy. Journal of Gastrointestinal Surgery, 26(2), 286–297. https://doi.org/10.1007/s11605-021-05216-6
World Obesity Federation. (2023). World Obesity Atlas 2023. www.worldobesity.org
Yunarto, N., Sulistyaningrum, N., Kurniatri, A. A., & Elya, B. (2021). Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia. Media Penelitian dan Pengembangan Kesehatan, 31(3), 183–192. https://doi.org/10.22435/mpk.v31i3.4472.
Arner, P., & Langin, D. (2014). Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance. Trends in Endocrinology and Metabolism: TEM, 25(5), 255–262. https://doi.org/10.1016/J.TEM.2014.03.002
Arundita, S., Ismed, F., Rita, R. S., & Putra, D. P. (2020). (+)-Catechin & Proanthocyanidin Fraction of Uncaria gambir Roxb. Improve Adipocytes Differentiation & Glucose Uptake of 3T3-L1 Cells Via Sirtuin-1, Peroxisome Proliferator-Activated Receptor γ (PPAR γ), Glucose Transporter Type 4 (GLUT-4) Expressions. Advanced Pharmaceutical Bulletin, 10(4), 602. https://doi.org/10.34172/APB.2020.072
Arundita, S., Kurniawan, F., Ismed, F., Rita, R. S., & Putra, D. P. (2020). In Vitro Alpha Glucosidase Activity of Uncaria gambir Roxb. and Syzygium polyanthum (Wight) Walp. from West Sumatra, Indonesia. Open Access Macedonian Journal of Medical Sciences, 8(A), 810–817. https://doi.org/10.3889/oamjms.2020.4298
Daudt, H. M. L., Van Mossel, C., & Scott, S. J. (2013). Enhancing the scoping study methodology: A large, inter-professional team's experience with Arksey and O'Malley's framework. BMC Medical Research Methodology, 13(1), 1–9. https://doi.org/10.1186/1471-2288-13-48/PEER-REVIEW
Dirir, A. M., Daou, M., Yousef, A. F., & Yousef, L. F. (2022). A review of alpha-glucosidase inhibitors from plants as potential candidates for the treatment of type-2 diabetes. Phytochemistry Reviews, 21(4), 1049–1079. https://doi.org/10.1007/s11101-021-09773-1
Feingold, K. R. (2020). Obesity and Dyslipidemia. In Endotext [Internet]. MDText.com, Inc. https://www.ncbi.nlm.nih.gov/books/NBK305895/
Fontenelle, L. C., de Araújo, D. S. C., da Cunha Soares, T., Cruz, K. J. C., Henriques, G. S., & do Nascimento Marreiro, D. (2022). Nutritional status of selenium in overweight and obesity: A systematic review and meta-analysis. Clinical Nutrition, 41(4), 862–884. https://doi.org/10.1016/J.CLNU.2022.02.007
Fu, M., Shen, W., Gao, W., Namujia, L., Yang, X., Cao, J., & Sun, L. (2021). Essential moieties of myricetins, quercetins and catechins for binding and inhibitory activity against α-Glucosidase. Bioorganic Chemistry, 115, 105235. https://doi.org/https://doi.org/10.1016/j.bioorg.2021.105235
Galán, J. P. M., Ontibón-Echeverri, C. M., Costa, M. C., Batista-Duharte, A., Batista, V. G., Mesa, V., Monti, R., de Paula, A. V., & Baviera, A. M. (2021). Enzymatic synthesis of capric acid-rich structured lipids and their effects on mice with high-fat diet-induced obesity. Food Research International, 148, 110602. https://doi.org/10.1016/J.FOODRES.2021.110602
Ghanemi, A., Yoshioka, M., & St-Amand, J. (2018). Broken Energy Homeostasis and Obesity Pathogenesis: The Surrounding Concepts. Journal of Clinical Medicine, 7(453), 1–12. https://doi.org/10.3390/JCM7110453
Gómez-Hernández, A., Beneit, N., Díaz-Castroverde, S., & Escribano, Ó. (2016). Differential Role of Adipose Tissues in Obesity and Related Metabolic and Vascular Complications. International Journal of Endocrinology, 2016, 1216783. https://doi.org/10.1155/2016/1216783
Hall, K. D., Farooqi, I. S., Friedman, J. M., Klein, S., Loos, R. J. F., Mangelsdorf, D. J., O’Rahilly, S., Ravussin, E., Redman, L. M., Ryan, D. H., Speakman, J. R., & Tobias, D. K. (2022). The energy balance model of obesity: beyond calories in, calories out. The American Journal of Clinical Nutrition, 115(5), 1243–1254. https://doi.org/10.1093/AJCN/NQAC031
Hilmi, H. L., & Rahayu, D. (2018). Review Artikel : Aktivitas Farmakologi Gambir (Uncaria Gambir Roxb.). Farmaka, 16(2), 134–141. https://doi.org/10.24198/JF.V16I2.17643.G8749
Huai, P., Liu, J., Ye, X., & Li, W.-Q. (2022). Association of Central Obesity With All Cause and Cause-Specific Mortality in US Adults: A Prospective Cohort Study. Frontiers in Cardiovascular Medicine, 9(816144). https://doi.org/10.3389/fcvm.2022.816144
Kemenkes RI. (2017). Farmakope Herbal Indonesia Edisi II. In Jakarta: Kementerian Kesehatan RI. Kementerian Kesehatan RI.
Montenegro Mendoza, R., Velásquez, I. M., Fontes, F., & Quintana, H. (2022). Prevalence of central obesity according to different definitions in normal weight adults of two cross-sectional studies in Panama. The Lancet Regional Health - Americas, 10, 100215. https://doi.org/https://doi.org/10.1016/j.lana.2022.100215
Munggari, I. P., Kurnia, D., Deawati, Y., & Julaeha, E. (2022). Current Research of Phytochemical, Medicinal and Non-Medicinal Uses of Uncaria Gambir Roxb.: A Review. Molecules, 27(19). https://doi.org/10.3390/MOLECULES27196551
Narciso, J., Nio, A., Silva, J., Rodrigues, V., Monteiro, M. J., Almeida, A. N., Saavedra, R., & Costa, A. M. (2019). Behavioral, contextual and biological factors associated with obesity during adolescence: A systematic review. PLoS One, 14(4), e0214941. https://doi.org/10.1371/journal.pone.0214941
Sugiura, C., Nishimatsu, S., Moriyama, T., Ozasa, S., Kawada, T., & Sayama, K. (2012). Catechins and caffeine inhibit fat accumulation in mice through the improvement of hepatic lipid metabolism. Journal of Obesity, 2012, 1–10. https://doi.org/10.1155/2012/520510
Suzuki, T., Pervin, M., Goto, S., Isemura, M., & Nakamura, Y. (2016). Beneficial Effects of Tea and the Green Tea Catechin Epigallocatechin-3-gallate on Obesity. Molecules, 21(10), 1305. https://doi.org/10.3390/MOLECULES21101305
Torres, J.-L., Usategui-Martín, R., Hernández-Cosido, L., Bernardo, E., Manzanedo-Bueno, L., Hernández-García, I., Mateos-Díaz, A.-M., Rozo, O., Matesanz, N., Salete-Granado, D., Chamorro, A.-J., Carbonell, C., Garcia-Macia, M., González-Sarmiento, R., Sabio, G., Muñoz-Bellvís, L., & Marcos, M. (2022). PPAR-γ Gene Expression in Human Adipose Tissue Is Associated with Weight Loss After Sleeve Gastrectomy. Journal of Gastrointestinal Surgery, 26(2), 286–297. https://doi.org/10.1007/s11605-021-05216-6
World Obesity Federation. (2023). World Obesity Atlas 2023. www.worldobesity.org
Yunarto, N., Sulistyaningrum, N., Kurniatri, A. A., & Elya, B. (2021). Gambir (Uncaria gambir Roxb.) as A Potential Alternative Treatment for Hyperlipidemia. Media Penelitian dan Pengembangan Kesehatan, 31(3), 183–192. https://doi.org/10.22435/mpk.v31i3.4472.
Published
2023-06-19
How to Cite
Manik, M., Rahardjo, S., & Febrinasari, R. (2023). A Scoping Review: Catechin-Rich Gambir as A Potential Functional for the Obesity Management. Proceedings of the International Conference on Nursing and Health Sciences, 4(1), 275-280. https://doi.org/10.37287/picnhs.v4i1.1815
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Articles
