Meta-Analysis: Association of Obesity with Incidence of Polycystic Ovarian Syndrome (PCOS)
Abstract
Polycystic Ovary Syndrome (PCOS) is one of the disorders that often attacks women that cause difficulty obtaining pregnancy. PCOS causes 5-10% of women of reproductive age to become infertile. In Indonesia itself, the exact incidence of PCOS is unknown. Most people with Polycystic Ovary Syndrome (PCOS) do not know that they have the syndrome. This cannot be separated from precipitating factors, one of which is obesity or high body mass index. The purpose of this meta-analysis was to estimate the strength of the effect of obesity on the incidence of PCOS. This study is a systematic review and meta-analysis. Primary data is retrieved through the electronic databases PubMed, Science Direct, Web of Science, Springer Link and Cochrane Database. By using the search keywords "obesity AND risk factor AND PCOS", "body mass index" AND "polycystic ovary syndrome". Articles taken between 2013-2023. Statistical analysis was performed using the RevMan 5.3 application. 6 articles qualified quantitatively for analysis. Increased body mass index or obesity, especially the abdomen, will increase the risk of PCOS 1.99-fold compared to women who have a normal body mass index and are statistically significant (OR 1.99; 95% CI: 1.79 – 2.20; p value < 0.001). Body mass index or obesity, especially the abdomen, will increase the risk of PCOS 1.99 times compared to women who have a normal body mass index.
References
Rodiani, R. &. G. R., 2019. Policystic Ovary Syndrom: Resiko Infertilitas yang dapat Dicegah melalui Penurunan Berat Badan Pada Wanita Obesitas. medicalprofession journal of lampung university, 9(1), pp. 267-275.
Chen, W. &. P. Y., 2021. Metabolic Syndrome and PCOS: Pathogenesis and the Role of Metabolites. Metabolites, 11(12).
Ibraheem, Q. e. a. .., 2020. Fat mass and obesity association gene polymorphism in PCOS iraqi women. Baghdad Science Journal, 17(3), p. pp.1103–1112.
Kazemi, M. e. a., 2021. Obesity, but not hyperandrogenism or insulin resistance, predicts skeletal muscle mass in reproductive-aged women with polycystic ovary syndrome: A systematic review and meta-analysis of 45 observational studies. Obesity Reviews, 22(8).
Ma, R. e. a., 2021. Obesity management in polycystic ovary syndrome: disparity in knowledge between obstetrician-gynecologists and reproductive endocrinologists in China. BMC Endocrine Disorders, 21(1).
Yang, P. e. a., 2021. Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production. Molecular Metabolism, Volume 49.
Moher, D. e. a., 2015. Preferred reporting items for systematic review and meta-analysis protocols. ( PRISMA-P ) 2015 statement, pp. 1-9.
Ryu, K. J. W. W. Y. N. S. J. H. G. C. G. J. P. H. &. K. T., 2023. Maternal Polycystic Ovary Syndrome and the Risk of Early Childhood Obesity in Female Offspring: A Nationwide Population-Based Study. Journal of Korean Medical Science, 38(14).
Liu, W. L. S. L. X. L. D. W. F. &. Z. Z., 2022. Assessment of neutrophil to lymphocyte ratio, C-reactive protein, mean platelet volume in obese, and nonobese patients with polycystic ovary syndrome.. Medicine, 101(29).
Saad, W. E. E. S. A. A. M. M. M. &. H. A. M. .. M. S., 2020. Study of the common variant rs9939609 of FTO gene polymorphism in Polycystic Ovary Syndrome. 24(106), pp. 3845-3854.
Bedrick, B. S. E. A. M. C. J. E. &. J. E. S., 2020. Self-administered questionnaire to screen for polycystic ovarian syndrome. Women's Health Reports, 1(1), pp. 566-573.
Greenwood, E. A. P. L. A. C. M. I. &. H. H. G., 2020. Obesity and depression are risk factors for future eating disorder-related attitudes and behaviors in women with polycystic ovary syndrome. Fertility and sterility, 113(5), pp. 1039-1049.
Venkatesh, S. S. F. T. B. S. R. N. B. C. M. G. I. .. &. W. L. B., 2022. Obesity and risk of female reproductive conditions: A Mendelian randomisation study. PLoS medicine, 19(2), p. e1003679.
Yang, P. et al., 2021. Obesity alters ovarian folliculogenesis through disrupted angiogenesis from increased IL-10 production. Mol. Metab, Volume 49, p. 101189.
Lerner, A. et al., 2020. Androgen Reduces Mitochondrial Respiration in Mouse Brown Adipocytes: A Model for Disordered Energy Balance in Polycystic Ovary Syndrome. Int. J. Mol. Sci, Volume 22, p. 243.
