Potensi Kandungan Biji Anggur dalam Mempercepat Penyembuhan Luka
Abstract
Luka adalah kondisi diskontinuitas skruktur anatomi jaringan tubuh mulai dari lapisan epitel kulit sampai lapisan jaringan subkutis, lemak, otot, tulang, serta struktur lain di sekitarnya seperti pembuluh darah, saraf, dan tendon akibat adanya trauma. Penyembuhan luka adalah proses dinamis yang meliputi unsur-unsur tubuh, pembuluh darah, fibroblast, dan sel epitel yang dirangkum dalam tiga fase utama yaitu fase inflamasi, fase proliferasi, dan fase maturasi. Biji anggur (Vitis vinifera L.) mengandung berbagai vitamin, karotenoid, senyawa polifenol, dan sterol yang menunjukkan efek menguntungkan pada penyembuhan luka. Tujuan dari tinjauan pustaka ini adalah untuk melaporkan temuan ilmiah terbaru tentang peran kandungan biji anggur dalam penyembuhan luka dengan sintesis kolagen, mencegah efek merusak dari radikal bebas, memastikan stabilitas dan integritas membran biologis, serta memproduksi kolagen yang mempercepat penyembuhan luka. Metode yang digunakan adalah metode literature searching melalui database NCBI dan Google Scholar. Tahun penerbitan sumber pustaka adalah dari tahun 2000 sampai tahun 2019 dengan 22 sumber pustaka. Tema yang dikumpulkan terkait dengan kandungan biji anggur terhadap penyembuhan luka. Hasil dari sintesis artikel yang telah ditemukan yaitu biji anggur bermanfaat dalam mempercepat penyembuhan luka.
Kata kunci: biji anggur, penyembuhan luka, polifenol
THE POTENTION OF GRAPE SEED TOWARD ACCELERATE HEALING WOUND
ABSTRACT
Wound is condition of discontinue anatomical structure of the body's tissue from the epithelial layer of the skin to the subcutaneous tissue layer, fat, muscle, bone, and other surrounding structures such as blood vessels, nerves, and tendons due to trauma. Wound healing is a dynamic process involving the body, fibroblasts, and epithelial cells which are summarized in three main phases, namely the inflammatory phase, the proliferation phase, and the maturation phase. Grape seeds (Vitis vinifera L.) contain various vitamins, carotenoids, polyphenol compositions, and sterols which have beneficial effects on wound healing. The purpose of this literature evaluation is to report the latest scientific findings on the role of grape seeds in wound recovery by collagen synthesis, prevent damage to free radicals, ensure and integrate biological membranes, and produce collagen that can repair wounds. The method used in this article is literature seacrhing through the NCBI database and Google Scholar. The year of reaching the library source is from 2000 to 2019 with 22 library sources. The theme collected is related to grape seeds on wound healing. The results of the synthesis of articles that have been found are grape seeds that are beneficial in improving wound healing.
Keywords: grape seed, healing wound, pholiphenol
References
Aubert, C., & Chalot, G. (2018). Chemical composition, bioactive compounds, and volatiles of six table grape varieties ( Vitis vinifera L.). Food Chemistry, 240, 524–533.
Abbas, A.K., Aster, J.C., dan Kumar, V. (2015). Buku Ajar Patologi Robbins. Edisi 9. Singapura: Elsevier Saunders.
De Jong A., Plat J., A. Bast, R. W. L. Godschalk, S. Basu, and R. P. Mensink. (2008). Effects of plant sterol and stanol ester consumption on lipid metabolism, antioxidant status and markers of oxidative stress, endothelial function and low-grade inflammation in patients on current statin treatment. European Journal of Clinical Nutrition, vol. 62, no. 2, pp. 263–273.
Fetterman J. W. Jr. and Zdanowicz M. M. (2009). Therapeutic potential of n-3 polyunsaturated fatty acids in disease. American Journal of Health-System Pharmacy, vol. 66, no. 13, pp. 1169– 1179
Granick, M.S., & Teot, L. (2012). Surgical Wound Healing and Management, ed. 2. USA : Informa Healthcare
Hemmati, A. A., Foroozan, M., Houshmand, G., Moosavi, Z. B., Bahadoram, M., & Maram, N. S. (2014). The Topical Effect of Grape Seed Extract 2% Cream on Surgery Wound Healing. Global Journal of Health Science, 7(3).
Horvath, G., Wessjohann, L., Bigirimana, J., Monica, H., Jansen, M., Guisez, Y., Horemans, N. (2006). Accumulation of tocopherols and tocotrienols during seed development of grape (Vitis vinifera L. cv. Albert Lavallée). Plant Physiology and Biochemistry, 44(11), 724–731.
João L. C., Helena G. S, Miguel J.N. R, Jorge C, José ED, Sara A, et al. (2019). Vitis flower types: from the wild to crop plants. Journal Plant Biology. PubMed 31737441
Jumanta. (2019). Buku pintar tumbuhan; segala yang perlu kita tahu tentang kehidupan mereka. Elex Media Komputindo; Jakarta. p34
Lee, S. K., & Kader, A. A. (2000). Preharvest and postharvest factors influencing vitamin C content of horticultural crops. Postharvest Biology and Technology, 20(3), 207–220.
Mendes-Pinto, M. M., Ferreira, A. S., Oliveira, M. B. P., & Guedes de Pinho, P. 2004. Evaluation of some carotenoids in grapes by reversed-and normal-phase liquid chromatography: A qualitative analysis. Journal of Agricultural and Food Chemistry, 52(10), 3182–3188.
Moalla Rekik, D., Ben Khedir, S., Ksouda Moalla, K., Kammoun, N. G., Rebai, T., & Sahnoun, Z. (2016). Evaluation of Wound Healing Properties of Grape Seed, Sesame, and Fenugreek Oils. Evidence-Based Complementary and Alternative Medicine, 2016, 1–12.
Nassiri-Asl, M., & Hosseinzadeh, H. (2009). Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytother Res, 23(9), 1197-1204
Nayak, B. S., Ramdath, D. D., Marshall, J. R., Isitor, G. N., Eversley, M., Xue, S., & Shi, J. (2009). Wound-healing activity of the skin of the common grape (Vitis Vinifera) variant, cabernet sauvignon. Phytotherapy Research, n/a–n/a
Perestrelo, R., Silva, C., Pereira, J., & Câmara, J. S. (2014). Healthy Effects of Bioactive Metabolites from Vitis vinifera L. Grapes: A Review. In Grapes: Production, Phenolic Composition and Potential Biomedical Effects (Nova Science Technology, pp. 305–338). José S. Câmara.
Potter A & Perry AG. (2006). Buku Ajar Fundamental Keperawatan: Konsep, Proses, dan Praktik. 4th ed. EGC: Jakarta.
Roy A, Saraf S. (2006). Limonoids: overview of significant bioactive triterpenes distributed in plant kingdom. Biol Pharm Bull 29: 191–201.
RISKESDAS. (2013). Riset Kesehatan Dasar. Departemen Kesehatan.
Sabiston C. D. (2011). Buku Ajar Bedah Sabiston (alih bahasa : Andrianto P &Timan I.S). Jakarta: Buku Kedokteran EGC.
Shi J, Yu J, Pohorly JE, Kakuda Y. (2003). Polyphenolics in grape seeds – biochemistry and functionality. J Med Food 6: 291–299.
USDA. (2017). USDA Food Composition Databases. https://ndb.nal.usda.gov/ndb/nutrients/index.
Velnar T, Bailey T,Smrkolj V. (2009). The wound healing process; an overview of cellular and molecular mechanism. The J of International Medical Research p1528-42



