Dampak Konsumsi Kopi pada Penurunan Kadar Glukosa Darah Penderita Diabetes Mellitus Tipe 2

Riski Handiani Anwari

doi:10.37287/jppp.v3i3.543

Riski Handiani Anwari Fakultas Kedokteran, Universitas Lampung

DOI: https://doi.org/10.37287/jppp.v3i3.543

Keywords: diabetes mellitus tipe 2, glukosa darah, kopi

Abstract

Diabetes mellitus tipe 2 merupakan suatu penyakit yang ditandai dengan tingginya kadar glukosa darah. Kadar glukosa darah yang tinggi pada penderita diabetes mellitus tipe 2 akan meningkatkan risiko terjadinya komplikasi seperti stroke, ketoasidosis diabetik, retinopati, ulkus diabetik dan komplikasi lainnya. Salah satu pengobatan yang direkomendasikan untuk menurunkan kadar glukosa darah pada penderita diabetes mellitus tipe 2 adalah dengan mengkonsumsi kopi. Oleh karena itu, literature review ini ditulis dengan tujuan untukelihat dampak konsumsi kopi pada penurunkan kadar glukosa darah penderita diabetes mellitus tipe 2. Metode yang digunakan adalah metode literature review dari 33 artikel terpilih yang ditemukan pada database NCBI, PubMed, dan Google Scholar dengan kata kunci “diabetes mellitus tipe 2”, “glukosa darah”, dan “kopi” dari tahun 2002 hingga 2021 yang kemudian dianalisis sesuai dengan metode sistematik literature review. Dari beberapa penelitian yang sudah dilakukan, didapatkan hasil bahwa mengkonsumsi kopi dapat menurunkan kadar glukosa darah pada penderita diabetes mellitus tipe 2.

References

Akash, M. S. H., Rehman, K., & Chen, S. (2014). Effects of coffee on type 2 diabetes mellitus. In Nutrition (Vol. 30, Issues 7–8).

https://doi.org/10.1016/j.nut.2013.11.020

Alam, S., Hasan, M. K., Neaz, S., Hussain, N., Hossain, M. F., & Rahman, T. (2021). Diabetes Mellitus: Insights from Epidemiology, Biochemistry, Risk Factors, Diagnosis, Complications and Comprehensive Management. Diabetology, 2(2), 36–50. https://doi.org/10.3390/diabetology2020004

Alperet, D. J., Rebello, S. A., Khoo, E. Y. H., Tay, Z., Seah, S. S. Y., Tai, B. C., Tai, E. S., Emady-Azar, S., Chou, C. J., Darimont, C., & Van Dam, R. M. (2020). The effect of coffee consumption on insulin sensitivity and other biological risk factors for type 2 diabetes: A randomized placebo-controlled trial. American Journal of Clinical Nutrition, 111(2).

https://doi.org/10.1093/ajcn/nqz306

Atlas, I. D. F. D. (2019). Internatonal Diabetes Federation. In The Lancet (Vol. 266, Issue 6881). https://doi.org/10.1016/S0140-6736(55)92135-8

Chen, L., Magliano, D. J., & Zimmet, P. Z. (2012). The worldwide epidemiology of type 2 diabetes mellitus - Present and future perspectives. In Nature Reviews Endocrinology (Vol. 8, Issue 4). https://doi.org/10.1038/nrendo.2011.183

Cole, J. B., & Florez, J. C. (2020). Genetics of diabetes mellitus and diabetes complications. In Nature Reviews Nephrology (Vol. 16, Issue 7).

https://doi.org/10.1038/s41581-020-0278-5

Ding, M., Bhupathiraju, S. N., Chen, M., Van Dam, R. M., & Hu, F. B. (2014). Caffeinated and decaffeinated coffee consumption and risk of type 2 diabetes: A systematicreview and a dose-response meta-analysis. Diabetes Care, 37(2), 569–586.

https://doi.org/10.2337/dc13-1203

Farah, A., & Donangelo, C. M. (2006). Phenolic compounds in coffee. Brazilian Journal of Plant Physiology, 18(1), 23–36. https://doi.org/10.1590/S1677-04202006000100003

Folwarczna, J., Janas, A., Pytlik, M., Cegieła, U., Śliwinśki, L., Krivošíková, Z., Štefíková, K., & Gajdoš, M. (2016). Effects of trigonelline, an alkaloid present in coffee, on diabetes-induced disorders in the rat skeletal system. Nutrients, 8(3).

https://doi.org/10.3390/nu8030133

Gao, F., Zhang, Y., Ge, S., Lu, H., Chen, R., Fang, P., Shen, Y., Wang, C., & Jia, W. (2018). Coffee consumption is positively related to insulin secretion in the Shanghai High-Risk Diabetic Screen (SHiDS) Study. Nutrition and Metabolism, 15(1).

https://doi.org/10.1186/s12986-018-0321-8

Higdon, J. V., & Frei, B. (2006). Coffee and health: A review of recent human research. Critical Reviews in Food Science and Nutrition, 46(2).

https://doi.org/10.1080/10408390500400009

Johnston, K. L., Clifford, M. N., & Morgan, L. M. (2003). Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: Glycemic effects of chlorogenic acid and caffeine. American Journal of Clinical Nutrition, 78(4). https://doi.org/10.1093/ajcn/78.4.728

Kementrian kesehatan republik indonesia. (2020). Tetap Produktif, Cegah Dan Atasi Diabetes Mellitus. In pusat data dan informasi kementrian kesehatan RI.

Kempf, K., Herder, C., Erlund, I., Kolb, H., Martin, S., Carstensen, M., Koenig, W., Sundvall, J., Bidel, S., Kuha, S., & Tuomilehto, J. (2010). Effects of coffee consumption on subclinical inflammation and other risk factors for type 2 diabetes: A clinical trial. American Journal of Clinical Nutrition, 91(4).

https://doi.org/10.3945/ajcn.2009.28548

Kerner, W., & Brückel, J. (2014). Definition, classification and diagnosis of diabetes mellitus. In Experimental and Clinical Endocrinology and Diabetes (Vol. 122, Issue 7).

https://doi.org/10.1055/s-0034-1366278

Kim, Y., Je, Y., & Giovannucci, E. (2019). Coffee consumption and all-cause and cause-specific mortality: a meta-analysis by potential modifiers. European Journal of Epidemiology, 34(8). https://doi.org/10.1007/s10654-019-00524-3

Kobayashi, M., Kurata, T., Hamana, Y., Hiramitsu, M., Inoue, T., Murai, A., & Horio, F. (2017). Coffee ingestion suppresses hyperglycemia in streptozotocin-induced diabetic mice. Journal of Nutritional Science and Vitaminology, 63(3), 200–207. https://doi.org/10.3177/jnsv.63.200

Lee, J. H., Oh, M. K., Lim, J. T., Kim, H. G., & Lee, W. J. (2016). Effect of coffee consumption on the progression of type 2 diabetes mellitus among prediabetic individuals. Korean Journal of Family Medicine, 37(1). https://doi.org/10.4082/kjfm.2016.37.1.7

Maulidia, A., & Jatmiko, S. W. (2021). Pengaruh Kopi terhadap Parameter Darah pada Tikus Putih Galur Wistar Diabetik yang Diinduksi Aloksan. Jurnal Kedokteran Dan Kesehatan, 17(1).

https://jurnal.umj.ac.id/index.php/JKK

Morran, M. P., Vonberg, A., Khadra, A., & Pietropaolo, M. (2015). Immunogenetics of type 1 diabetes mellitus. In Molecular Aspects of Medicine (Vol. 42).

https://doi.org/10.1016/j.mam.2014.12.004

Olokoba, A. B., Obateru, O. A., & Olokoba, L. B. (2012). Type 2 diabetes mellitus: A review of current trends. In Oman Medical Journal (Vol. 27, Issue 4). https://doi.org/10.5001/omj.2012.68

PERKENI. (2011). Konsensus Diabetes Mellitus. Perkeni, 16(1994), 1–27.

Petersmann, A., Müller-Wieland, D., Müller, U. A., Landgraf, R., Nauck, M., Freckmann, G., Heinemann, L., & Schleicher, E. (2019). Definition, Classification and Diagnosis of Diabetes Mellitus. Experimental and Clinical Endocrinology and Diabetes, 127.

https://doi.org/10.1055/a-1018-9078

Power, D. (2019). Standards of medical care in diabetes: Response to position statement of the American Diabetes Association [20]. Diabetes Care, 29(2), 476. https://doi.org/10.2337/diacare.29.02.06.dc05-1593

Prasetyo, A., & Sutanta. (2015). Pengaruh Konsumsi Seduhan Bubuk Biji Kopi Terhadap Kadar Gula Darah Sewaktu Pada Penderita Diabetes. Jurnal Kesehatan Madani Medika, 6(1), 14–20.

Ranheim, T., & Halvorsen, B. (2005). Coffee consumption and human health - Beneficial or detrimental? - Mechanisms for effects of coffee consumption on different risk factors for cardiovascular disease and type 2 diabetes mellitus. In Molecular Nutrition and Food Research (Vol. 49, Issue 3). https://doi.org/10.1002/mnfr.200400109

Ren, Y., Wang, C., Xu, J., & Wang, S. (2019). Cafestol and kahweol: A review on their bioactivities and pharmacological properties. In International Journal of Molecular Sciences (Vol. 20, Issue 17). https://doi.org/10.3390/ijms20174238

Rother, K. I. (2007). Diabetes Treatment — Bridging the Divide. New England Journal of Medicine, 356(15). https://doi.org/10.1056/nejmp078030

Subeki, & Muhartono. (2015). Pengaruh Pemberian Infusa Kopi dalam Menurunkan Kadar Glukosa Darah Mencit yang Diinduksi Aloksan The Effect of Coffee Infusion in Lowering Blood Glucose Level in Mice Induced by Alloxan. Juke Unila, 5(9), 1–8.

Tjahjono, H., & Danang, E. (2019). Pengaruh terapi kopi terhadap kadar gula darah acak pada pasien diabetes militus tipe 2 di desa waru beron rt. 06 rw. 02 balongbendo sidoarjo. Jurnal keperawatan, 3(2), 8

http://jurnal.stikeswilliambooth.ac.id/index.php/d3kep/article/view/7

van Cruchten, S. T. J., de Haan, L. H. J., Mulder, P. P. J., Kunne, C., Boekschoten, M. V., Katan, M. B., Aarts, J. M. M. J. G., & Witkamp, R. F. (2010). The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol. Journal of Nutritional Biochemistry, 21(8). https://doi.org/10.1016/j.jnutbio.2009.05.001

WHO Global Report on Diabetes. (2016). Global Report on Diabetes. Isbn, 978, 6–86.

https://sci-hub.si/https://apps.who.int/iris/handle/10665/204874%0Ahttps://apps.who.int/iris/bitstream/handle/10665/204874/WHO_NMH_NVI_16.3_eng.pdf?sequence=1%0Ahttp://www.who.int/about/licensing/copyright_form/index.html%0Ahttp://www.who.int/about/licens

Yustisiani, A., Andari, D., & . I. (2013). Pengaruh Pemberian Kopi Terhadap Penurunan Kadar Glukosa Darah Pada Tikus Putih Strain Wistar Diabetes Mellitus Tipe 2. Saintika Medika, 9(1), 38. https://doi.org/10.22219/sm.v9i1.4124