Efek Mangiferin dalam Mengatasi Masalah Kesehatan
Abstract
Masalah kesehatan terbesar di dunia disebakan oleh penyakit tidak menular seperti penyakit jantung, kanker, penyakit pernapasan, dan diabetes melitus. Prevalensi penyakit tidak menular lebih tinggi pada negara yang berpenghasilan rendah serta menengah daripada negara yang berpenghasilan tinggi. Berbagai pengobatan dilakukan untuk mengatasi penyakit tersebut seperti penggunaan obat oral. Namun, beberapa obat memiliki efek samping tertentu yang mengakibatkan penyakit lain. Pengobatan alternatif yang dilakukan yaitu menggunakan pengobatan herbal yang didapatkan dari tanaman. Salah satu tanaman yang memiliki potensi herbal yaitu Mangga (Mangifera) yang memiliki kandungan senyawa mangiferin. Senyawa tersebut memiliki efek farmakologi yang dapat dijadikan obat untuk penyakit tersebut. Tujuan review ini untuk menjelaskan efek Mangiferin sebagai terapi masalah kesehatan terutama pada penyakit tidak menular pada penelitian sebelumnya. Review ini disusun dengan melakukan penulusuran artikel melalui database NCBI dan Google Scholar. Hasil dari penelusuran artikel yang ditemukan yaitu Mangiferin memiliki efek antikanker, antiinflamasi, antidiabetes, antioksidan dan kardioprotektor yang dapat dijadikan terapi untuk mengatasi berbagai masalah kesehatan. Saran untuk dunia penelitian lebih dikembangkan lagi mengenai potensi tanaman herbal terutama buah mangga sehingga dapat digunakan sebagai pengobatan.
Kata Kunci: mangga, mangiferin, efek farmakologi
EFFECT OF MANGIFERIN ON OVERCOMING HEALTHY PROBLEMS
ABSTRACT
The biggest health problem in the world is caused by non-communicable diseases such as heart disease, cancer, respiratory disease, and diabetes mellitus. The prevalence of non-communicable diseases is higher in countries with low and middle income than countries with high income. Various treatments are carried out to overcome the disease such as the use of oral drugs. However, some drugs have side effects that cause other diseases. Alternative medicine is carried out using herbal treatments obtained from plants. One of the plants that has herbal potential is Mango (Mangifera) which contains mangiferin compounds. These compounds have pharmacological effects that can be used to treatment the disease. This review article aims to explain the effects of Mangiferin as a therapy for health problems, especially in non-communicable diseases in previous studies. The method used in this article is through searching articles through the NCBI database and Google Scholar. The results of an article search found that Mangiferin has anticancer, anti-inflammatory, antidiabetic and antioxidant effects that can be used as therapies to treat a variety of health problems. Suggestion for all researchers is more developed about the potential of herbal plants especially mangoes so that it can be used as a treatment.
Keyword : mango (mangifera), mangiferin, pharmacological effect
References
Anggraini, O. D., Komariah, C., & Prasetyo, A. (2018). Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin (The Effect of Arumanis Mango Peel Extract on Decreasing the Paw Oedema in White Male Mice Induced by Carrageenin). e-Jurnal Pustaka Kesehatan, 6(2), 267–271.
Arozal, W., Suyatna, F., Juniantito, V., Rosdiana, D., Amuragam, S., Aulia, R., Siswandi, R. (2014). The effects of mangiferin (Mangifera indica L) in doxorubicin-induced cardiotoxicity in rats. Drug Res (Stuttg), 65, 574–580.
Bally, I. S. E. (2006). Mangifera indica (mango). Spesies Profiles for Pacific Island Agroforestry, 3–I(April), 1–25.
Dinesh, M. R., Vasanthalah, H. K. N., Ravishankar, K. V, Thangadurai, D., Narayanaswamy, P., Ali, Q., Basha, S. M. (2011). Mangifera. C. Kole (ed.), Wild Crop Relatives: Genomic and Breeding Resources, Tropical and Subtropical Fruits, (June). https://doi.org/10.1007/978-3-642-20447-0
Forouzanfar, M. (2017). Global , regional , and national comparative risk assessment of 79 behavioural , environmental and occupational , and metabolic risks or clusters of risks , 1990 – 2015 : a systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388, 1990–2015. https://doi.org/10.1016/S0140-6736(16)31679-8
Giron, M., Sevillano, N., Salto, R., Haidour, A., Manzano, M., Jimenez, M., Pedrosa, L. (2009). Salacia oblonga extract increases glucose transporter 4-mediated glucose uptake in L6 rat myotubes: role of mangiferin. Clin Nutr, 28, 565–574.
Guo, F., Huang, C., Liao, X., Wang, Y., He, Y., Rennan Feng, Sun, C. (2011). Beneficial effects of mangiferin on hyperlipidemia in high-fat-fed hamsters. Molecular Nutrition and Foof Research, 55(12), 1809–1818.
Ima, A., Setia, D., Tjitaresmi, A., Farmasi, F., & Padjajaran, U. (2010). Aktivitas Antiinflamasi dari Berbagai Tanaman : Sebuah Review. Farmaka, 14(1), 77–86.
Imran, M., Arshad, M. S., Butt, M. S., Kwon, J., Arshad, M. U., & Sultan, M. T. (2017). Mangiferin : a natural miracle bioactive compound against lifestyle related disorders. Biomed central, 16(84), 1–17. https://doi.org/10.1186/s12944-017-0449-y
Jain, P. K., Kharya, M., & Gajbhiye, A. (2013). harmacological evaluation of mangiferin herbosomes for antioxidant and hepatoprotection potential against ethanol induced hepatic damage. Drug Development and Industrial Pharmacy, 39(October 2012), 1840–1850. https://doi.org/10.3109/03639045.2012.738685
Jeong, J., Jang, S., Hyam, S. R., Joo, M., & Kim, D. (2014). Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF- κ B and MAPK pathways. European Journal of Pharmacology, 740(2014), 652–661. https://doi.org/10.1016/j.ejphar.2014.06.013
Li, T., Liang, S., Zhang, Y., & Chen, Y. (2015). Effects of microRNA-139 on myocardial cell injury induced by oxidative stress. Int J Clin Exp Med, 8(11), 19994–20001.
Lim, S., Son, K. R., Song, I. C., Park, H. S., Jin, C. J., Jang, H. C., Lee, H. K. (2009). Fat in Liver / Muscle Correlates More Strongly With Insulin Sensitivity in Rats Than Abdominal Fat. Obesity Journal, 17(1),188–195. https://doi.org/10.1038/oby.2008.486
Nurcahyanti, A. dwi retno. (2019). Mangifera and Impatiens from Sumatra : Phylogenetic Positions and their Modes of Action as Anticancer Agents, 16–23. https://doi.org/10.4103/phrev.phrev
Peng, Z. G., Yao, Y. B., Yang, J., Tang, Y. L., & Huang, X. (2015). Mangiferin induces cell cycle arrest at G2 / M phase through ATR-Chk1 pathway in HL-60 leukemia cells. Genetics and Molecular Research, 14(2), 4989–5002.
Pratama, F. E., & Nuwarda, R. F. (2018). Review : Senyawa Aktif Antikanker Dari Bahan Alam dan Aktivitasnya. Farmaka Suplemen, 16(1), 149–158.
Rajendran, P., Rengarajan, T., Nandakumar, N., Divya, H., & Nishigaki, I. (2014). Mangiferin in cancer chemoprevention and treatment : pharmacoki- netics and molecular targets, 9893, 1–9. https://doi.org/10.3109/10799893.2014.931431
Saleh, S., El-maraghy, N., Reda, E., & Barakat, W. (2014). Modulation of Diabetes and Dyslipidemia in Diabetic Insulin-Resistant Rats by Mangiferin : Role of Adiponectin and TNF-α. An Acad Bras Cienc, 86(4), 1935–1947.
Siswanty, P. W., Wibowo, M. A., & Harlia. (2017). Aktivitas Toksisitas Antioksidan dan Antiinflamasi Secara In Vitro Dari Ekstrak Metanol Daun Mangga Bacang (Mangifera foetida L). JKK, 6(1), 42–49.
Syah, M. I., Suwendar, & Mulqie, L. (2015). Uji Aktivitas Antidiabetes Ekstrak Etanol Daun Mangga Arumanis (Mangifera indica L. “Arumanis”) pada Mencit Swiss Webster Jantan dengan Metode Tes Toleransi Glukosa Oral (TTGO). Prosiding Penelitian Spesia Unisba, 2, 297–303.
Tobinick. (2009). The Value of Drug Repositioning in The Current Pharmaceutical Market. Drug News and Perspectives, 22(2), 119.
WHO. (2011). Global status report on noncommunicable diseases.
Zheng, D., Hou, J., Xiao, Y., Zhao, Z., & Chen, L. (2012). Cardioprotective Effect of Mangiferin on Left Ventricular Remodeling in Rats. Pharmacology, 90, 78–87. https://doi.org/10.1159/000339450
Zhou, M., Xu, A., Lam, K. S. L., Tam, P. K. H., Che, C., Chan, L., Wang, Y. (2010). Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. Journal of Hepatology, 53(6), 1108–1116. https://doi.org/10.1016/j.jhep.2010.05.034
![88+ Daftar Jurnal Sinta 5 Gratis Yang Terbit Bulan Ini? [Update 2022]](https://stiqwalisongo.ac.id/wp-content/uploads/2020/10/sinta-5.jpg){kind=small}
