Efek Antidiabetik Dari Aloe Vera

Cantika Larasati

doi:10.37287/jppp.v3i1.252

Cantika Larasati Universitas Lampung

DOI: https://doi.org/10.37287/jppp.v3i1.252

Keywords: aloe vera, diabetes mellitus

Abstract

Diabetes melitus merupakan kelainan metabolisme kronis yang ditandai dengan hiperglikemia dengan gangguan metabolisme karbohidrat, lemak, dan protein. Pasien dengan diabetes mellitus seringkali memiliki kontrol glikemik yang buruk dan memiliki banyak risiko komplikasi mikrovaskuler. Obat hipoglikemik sintetik tidak dapat sepenuhnya mengontrol kadar glukosa serta seringkali menimbulkan efek samping yang menyebabkan ketidakpatuhan pasien minum obat. Selama berabad-abad, obat-obatan herbal telah banyak digunakan untuk mengobati berbagai macam penyakit yang sampai saat ini masih digunakan sebagai alternatif pertama untuk menyembuhkan penyakit tertentu di negara berkembang. Aloe vera telah digunakan oleh berbagai budaya karena khasiat obatnya yang luar biasa. Penelitian ini merupakan literature review yang melibatkan sebanyak 21 sumber pustaka dengan kata kunci yang digunakan yaitu ‘aloe vera dan diabetes’ dengan tahun terbit antara 2009- 2020. Abstrak dan full text jurnal dibaca dan dicermati, kemudian dilakukan analisis terhadap isi yang terdapat dalam tujuan penelitian dan hasil/temuan penelitian. Banyak studi menunjukkan ekstrak aloe vera dapat berperan dalam menurunkan glukosa darah pada penderita diabetes mellitus dan komplikasinya melalui berbagai mekanisme, seperti menurunkan glukoneogenesis dan lipogenesis, serta meningkatkan glikolisis di hati. Selain itu, aloe vera dapat mempengaruhi ekspresi gen berbeda yang terkait dengan metabolisme glukosa dan lipid. serta dikaitkan dengan aktivasi transkripsi PPAR. Kandungan senyawa dan vitamin didalamnya juga berperan sebagai antioksidan. Kandungan senyawa pada gel aloe vera menunjukkan berbagai manfaat antidiabetes, dan kandungan polisakarida di dalamnya dianggap sebagai komponen aktif utama untuk manfaat tersebut.

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